Surbhi Narang
12
Seguidores
Etiquetas
intraventricular drug infusion intracerebral impl
vitamins and hormones. the more lipophilic substan
nucleosides
purine bases
amines
acidic amino acids
basic amino acid
neutral amino acids
monocarboxylic acid
and effect on all of the above by the existing pa
affinity for carrier mechanisms
hydrogen bonding potential (i.e. charge)
affinity for efflux mechanisms (i.e. p-glycoprotei
cellular enzyme stability and cellular sequestrati
ionization (nonionized form penetrates bbb) lipoph
conformation
flexibility
constitute the bbb. rate-limiting factor in deter
together with perivascular elements such as astro
brain targeted drug delivery system prepared by :
concept of optimization optimisation in formulatio
similarity factor (f2) (
16). ● model independent methods [difference facto
etc.) (15
weibull model
baker-lonsdale model
hixson crowell
korsmeyer-peppas model
higuchi
first order
14). ● model dependent methods (zero order
multivariate approach [manova: multivariate analys
repeated measures design
● statistical methods (exploratory data analysis m
nernst and brunner film theory
noyes-whitney rule
kinetic modeling on drug release from controlled d
laser desorption
protein analysis
atmospheric pressure photoionization
electrospray ionization
mass spectroscopy
desorption ionization techniques
fab
maldi
apci
appi
esi
diazonium salts
chemical derivatisation
ultra voilet
spectroscopy
uv chemical derivatisation
insulin delivery system
rate controlled drug delivery system
triggering agent
feedback regulated drug delivery system
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