Atopic Dermatitis Insights and Treatments

Atopic dermatitis: A deep insight and therapeutic implications By Dr. M. Y. Abd-Elmawla MD Dermatology And Venereology

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Immunohistology of the skin ,[object Object],[object Object],[object Object],[object Object]

Systemic Immune Response In AD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Biphasic pattern of cytokine expression in atopic skin lesions ,[object Object],[object Object],[object Object],[object Object]

Factors affecting the differentiation of helper T cells in AD ,[object Object],[object Object],[object Object],[object Object],[object Object]

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FLG expression and functions in the skin barrier:1 ,[object Object],[object Object],[object Object],[object Object],[object Object]

FLG expression and functions in the skin barrier:2 ,[object Object],[object Object],[object Object],[object Object]

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Factors contributing to Skin Localization of Allergic Disease ,[object Object],[object Object],[object Object]

Mechanisms of Chronic Skin Inflammation in AD ,[object Object],[object Object],[object Object]

FLG insufficiency and bacterial infections in atopic dermatitis ,[object Object],[object Object]

Atopic dermatitis versus psoriasis inflammatory reaction

Proposed criteria for the diagnosis of AD. Keratoconus Anterior capsular cataracts Palmar hyperlinearity Morgan-Dennie lines Allergic shiners Vascular instability Pityriasis alba Eczematous lesions Keratosis pilaris Pruritus Xerosis Atopy (personal or family history) Nonessential Essential

DIFFERENTIAL DIGNOSIS of AD History of recurrent infection Immunodeficiency disorder Serpiginous plaques with central clearing, positive potassium hydroxide preparation Dermatophyte infection Vesicles over extensor areas and associated enteropathy Dermatitis herpetiformis Findings on complete history and physical examination vary by disease Systemic diseases Papules, finger web involvement, positive skin scraping Scabies Positive exposure history, rash in area of exposure, absence of family history Contact dermatitis Usually, a single patch in an area accessible to itching; absence of family history Neurodermatitis Localized patches on extensor surfaces, scalp, buttocks; pitted nails Psoriasis

HYDRATION and MOISTURIZERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Topical Tacrolimus & Pimecrolimus ,[object Object],[object Object],[object Object],[object Object],[object Object]

Systemic immunomodulators ,[object Object],[object Object],[object Object],[object Object],[object Object]

Systemic immunomodulators (cont..) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Omalizumab for Treatment of A D ,[object Object],[object Object]

Alogrithm : Treatment of atopic dermatitis .

Conclusion and Future directions ,[object Object],[object Object],[object Object]

Atopic Dermatitis Insights and Treatments

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