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/   /
/   /
3
4
5
6
7
8
9




L
10




                 L

100mg                 2μg/ml(=2mg/L)
100(mg)/2(mg/L)=50L
                          1kg          1L
11
12




(L)=   (mg)/               (mg/L)



               Vd (L/kg)

               0.3

         0.5-1

                     >1
13
14
15
16




    1-1.5mg/kg




17mg/kg
17




                   1.5mg/kg        ×
                                                        10


        50kg                                       Vd


×Vd 50kg×1.1L/kg         L


kg×1.5mg/kg×                  mg



      mg /           L             mg/L   =μg/ml
18




                     1.5mg/kg      ×


         50kg                                    Vd
Vd=1.1L/kg
×Vd 50kg×1.1L/kg 55        L



kg×1.5mg/kg×             150 mg



150   mg /      55   L     2.7   mg/L   =μg/ml

                2-5μg/ml
19




                                  17mg/kg
                                3.6            30


        50kg                                        Vd


×Vd 50kg×1.9L/kg            L



kg×17mg/kg             mg



      mg /         L        mg/L      =μg/ml
20




                                                  17mg/kg


              50kg
Vd                Vd=1.9L/kg

     ×Vd 50kg×1.9L/kg          95     L



     kg×17mg/kg        850 mg



     850   mg /   95    L      8.95       mg/L   =μg/ml

                     4-10μg/ml
21




    50kg                          250mg


                  50kg                                    Vd


           ×Vd 50kg×0.5L/kg               L

                                              250mg



                mg /          L           mg/L   =μg/ml

→
22




    50kg                              250mg


                   50kg                                     Vd
           Vd=0.5L/kg

           ×Vd 50kg×0.5L/kg       25 L

                                                 250mg



    250    mg /       25 L     10 mg/L        =μg/ml

                          5-15μg/ml           >20μg/ml

→


            10μg/ml                               20μg/ml
23




    1-1.5mg/kg




17mg/kg
24
25
26




               (CCB)




loading dose
27
28




4   5
29




4         5
    95%
30
31




H2 blocker



      iatrogenic
32




             4




iatrogenic

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Pharmacokinetics icu setting_2007_nagoya

  • 1. / /
  • 2. / /
  • 3. 3
  • 4. 4
  • 5. 5
  • 6. 6
  • 7. 7
  • 8. 8
  • 9. 9 L
  • 10. 10 L 100mg 2μg/ml(=2mg/L) 100(mg)/2(mg/L)=50L 1kg 1L
  • 11. 11
  • 12. 12 (L)= (mg)/ (mg/L) Vd (L/kg) 0.3 0.5-1 >1
  • 13. 13
  • 14. 14
  • 15. 15
  • 16. 16 1-1.5mg/kg 17mg/kg
  • 17. 17 1.5mg/kg × 10 50kg Vd ×Vd 50kg×1.1L/kg L kg×1.5mg/kg× mg mg / L mg/L =μg/ml
  • 18. 18 1.5mg/kg × 50kg Vd Vd=1.1L/kg ×Vd 50kg×1.1L/kg 55 L kg×1.5mg/kg× 150 mg 150 mg / 55 L 2.7 mg/L =μg/ml 2-5μg/ml
  • 19. 19 17mg/kg 3.6 30 50kg Vd ×Vd 50kg×1.9L/kg L kg×17mg/kg mg mg / L mg/L =μg/ml
  • 20. 20 17mg/kg 50kg Vd Vd=1.9L/kg ×Vd 50kg×1.9L/kg 95 L kg×17mg/kg 850 mg 850 mg / 95 L 8.95 mg/L =μg/ml 4-10μg/ml
  • 21. 21 50kg 250mg 50kg Vd ×Vd 50kg×0.5L/kg L 250mg mg / L mg/L =μg/ml →
  • 22. 22 50kg 250mg 50kg Vd Vd=0.5L/kg ×Vd 50kg×0.5L/kg 25 L 250mg 250 mg / 25 L 10 mg/L =μg/ml 5-15μg/ml >20μg/ml → 10μg/ml 20μg/ml
  • 23. 23 1-1.5mg/kg 17mg/kg
  • 24. 24
  • 25. 25
  • 26. 26 (CCB) loading dose
  • 27. 27
  • 28. 28 4 5
  • 29. 29 4 5 95%
  • 30. 30
  • 31. 31 H2 blocker iatrogenic
  • 32. 32 4 iatrogenic