Excellence of Rasaushadhi research

Excellence of Rasaaushadhi In Ayurveda Practice – Part 2

Our Role in Establishment
of
Rasa-Aushadhi Glory in
General Ayurveda Practice
Instead of cursing the darkness
Try to lit a small LIGHT –
It becomes FLAME
one day to cook your food

1
Dr. K. Shiva Rama Prasad, at http://technoayurveda.wordpress.com/

స “రస” ైదుయ్లకు అ నందనల ో
A
Technoayurveda International
Presentation
In
Association with
Ayurmitra
Technoayurveda.wordpress.com

Rasashastra Re-Orientation Program at
NRS Govt. Ayurveda College, Vijayawada
on 15-12-2009
2

Excellence of Rasaaushadhi In Ayurveda Practice
Rasa Aushadhi Common Diseases in GAP Research in RT

Dhatuvada - Dehavedha

न च रसशास्तर्ं धातुवादाथर्मेवेित मन्तव्यं
दे हवेधद्वार मुक्तरे व परम ूयोजनत्वात ्
े
रसेश्वर दशर्न
 Conversion of the lower metals to higher is
the job of “Chemistry”.
 What is expected from “Rasashastra” is to
make is the “Dehavedha” for the body to
attain the “Mukti” from “Disease”

3


Introduction

• Rasashastra a Scientific Chemotherapy
of Ayurveda is at Cross-Roads
• The influences and advancements of -
– “Pharmacy standards”
– “Evidence Based Medicine protocols”
– A major Global “Toxic concept campaign” and
– “Ayurveda Fraternity Deception”
• - are making panic to the Ayurveda
community in general and Rasashastra
(Pharmacy) division in specific.
4


Ayurveda in Research
• The Excellency to bring back – Research in
the any branch especially in Rasashastra is
essential.
• Ayurveda has many units of Research like –
CCRAS, ICMR and many NGOs for making
Research and informing the Research fruits
to the user.
– Whether the Researches in Ayurveda are
User demand fulfillments?
– Are the Researches followed are up to
the International standard to accept
Globally our Medicine?
– Are we make user to satisfy by the –
• “Standard”
• “Effect” or
• “Free of Toxicity”
• By any other way . . . At least . . .
5


Need of the Hour

• To be frank the researches in Ayurveda
are not user friendly and could not reach
the ultimate user – General Ayurveda
Practitioner
• As we are at the Rasashastra researches
in concern at present – it is necessary to
know how the researches are made in this
branch.

6


Research in General

• Researches are of many folds to obtain
the “True Knowledge” – A search again
and again to get the perfect knowledge.
• Commonly followed are –
– 1. Explorative Research
• Literary
• Experience survey
– 2. Conclusive
• Descriptive
• Experimental
7


Research Process
• Problem definition
• Objectives set: purpose – place – status - means
– Research questions
– Hypothesis
– Boundary of the study
• Research design
– Sampling – experiment – questioners
• Data collection
• Data analysis
• Interpretation of results – should be with real world
problem and conclusion
• Validation of results
8

ushadhi Common Diseases in GAP Research in RT Activity in Research

Is Rasa-Medicine is Target oriented?
Rasa Parpati

Samanya Shodhana Godugdha
Parada Gandhaka Ghrita Bharjita Shodhita
Gandhaka
Samanya Bhringaraja
Shodhana

with Lime Powder
Hingulottha
Lashuna + Saindhava Parada Parpati 1 of 2

Parpati 2 of 4
Shodhita Parada What Target differences are brought in usage of these
combinations and permutations with set of combinations
and permutations of Anupana, Sahapana in General
Ayurveda Practice
9


Is Rasa-Medicine is Target oriented?

A cutting edge technology is the need of hour in Ayurveda.
The road beyond Production & Practice should be visualized.

Dravya Shodhana Probable?
Parada Hingulotha (Alimentary) Pittahara?
Lime powder (Ca+)(neural) Vatahara?

Lasuna + (Tissue invader)
Saindhava Kaphahara?
Gandhaka Godugdha Agni?
Bhringaraj Panchabhutagni?
Whether the “Shodhana” makes the Dravya to reorganize the Chemical bonding?
10


Parpati in Practice

Parpati Additives Target
Rasa Rasa + Gandhaka Annavaha, Udakavaha
(Base combination) Rasavaha, Lasika (Twak)
Panchamruta + Loha, Abhraka Annavaha, Pranavaha
Tamra Sukravaha
Bola + Bola Rakta vaha, Artavavaha
Loha + Loha Annavaha, Lasika (Twak)
Swarna + Swarna Annavaha, Pranavaha
Sukravaha
Tamra + Tamra, Annavaha, Mootravaha
Vatsanabha Lasika (Twak)
Sweta Soraka, Sphatika, Annavaha, Mootravaha
Navasara 11


Raw drug collection - Identification Who Answers ?

Ingredient Is there any Genotoxicity ?
Multiple Bhavana
Drug concentrations
Shodhana to maintain half life?
Marana
Pharmaceutical

Drug Excretion ?
Single / Multiple
Multi Drug Target Action?
Shodhita
combinations
Ingredients
Multiple Pharmaco-
Multiple Preparation dynamics
Clinical
methods attitudes
Anupana
Multiple Pharmacokinetics Sahapana
Aushadha Kaala

12


Another Example of Kupipakwa Rasayana

• In Kupi pakwa Rasayana procedures – the medicine
collection is from the “Talastha” or “Kantastha” and
“Ubhayastha”.
• Taking the example of “Somanatha tamra Bhasma and
Malla Sindhura (Tamra sindhura) are from one preparation.
– The “Kantastha” – called as Tamra Sidhura acts on STI, Tamaka
Swasa
– Where as – the “Talastha” collection called as Tamra Bhasma
acts on – many diseases, especially on Annvaha, Pranavaha,
Twak vikara, etc.
• What makes the difference of collection in a process?
• Whether the target is to prepare one medicine in a
pharmaceutical procedure or two Birds in one shot?
• Does such short cut methods are encouraged by the Learned
community?

13

ommon Diseases in GAP Research in RT Activity in Research Research Methods to Adopt

What Literary Research?

• Literary research in Rasashastra has a
wide scope and is the need of the hour.
• The print available Rasashastra books are
few and the abundance of Manuscripts
makes – a chance to explore Rasashastra.
• For Eg. – a preparation have many
dialects of preparation methods –
scrutinizing them makes us to have a
target oriented potent Medicine to reach.
14

ommon Diseases in GAP Research in RT Activity in Research Research Methods to Adopt

How to survey in RT
• Survey and education of Rasa medicine
usage in the practice is recorded –
– What is the need for Practitioner?
• Symptom target
• Disease target
• Organ target
• System target
• Health target
– What medicines are causing the adverse
effects? – Classified Recordings of -
• Hypersensitivity
• Hepato toxicity
• Nephro toxicity
• Neuro toxicity 15

mmon Diseases in GAP Research in RT Activity in Research Research Methods to Adopt

Do we do Descriptive Research in RT

• Much of the present day Researches are
following the Descriptive Method researches
– which are with limited scope - as –
• Prospective study – common
– Physico / Pharmaco -chemical studies
– Drug effect in clinical study
• Retrospective study – Reverse
pharmacology study - uncommon in
Ayurveda
16

Research in RT Activity in Research Research Methods to Adopt Research Models

Experimental Research in RT

Experimental studies have no pickup in
Ayurveda because of non-efficiencies
/exposure in maintenance of –
 Animal Houses and
 Analytical lab.
The limping or dependent studies are
successful some times but not yielding
the full-fledged fruits and results to the
Ayurveda community.
More systematic animal experiments
and lab studies are required as the
AYUSH is funding and encouraging for
the “Expressive Projects”
17

Activity in Research Research Methods to Adopt Research Models

Research Models in RT

• Best Research model for successful
Penetration Rating in to market is through
fulfilling the peoples needs –
• Mathematical –
– Inventory
– Parametric
– Replacement
• Algorithmic – is a well-defined sequence steps
to solve a problem
– Combinational
– Polynomial

18


Inventory Research

• Present day researches seems to validate ancient
formulations rather than productivity
• No contribution of the “Neo-Rasashastra” is
brought forward
• An inventory model is –
– Classify and visualize the old formula as TLC, HPTC,
Finger print technology, etc
– Chemical structure is identified
– Reconstruct the chains for validation and comparison
– Restructure the combination to the needs of user
– Rejuvenation of Vedic Chemistry
– There by combating the present day dreadful diseases

19


Parametric Research

• A classical design of Research (validation)–
mere Chemical constituents – studied with -
– Pre-fixed Parameters
– Chemical structure evaluated
– Limited framework to study
• A locality
• One medicine
• Small duration
– Mono-directional
– Target based
– Result oriented

20


Replacement Research

• In Ayurveda – we are commonly using the
substitutes –
– Whether the replacements are equivalent?
– Does they give exactly results as their substitutes?
– we don’t know!
• Instead – using Replacement Research is
better – here we replace with –
– Standard replacement
– Equivalent replacement (based on Rasa, Guna, etc)
– Omitting replacement
– Complete replacement

21

Research Methods to Adopt Research Models GAP in Research Conclusion

Combinational Research

• The medicines commonly used are of Herbo-
mineral combinations
• The combinational research in Rasashastra is
defined as –
– A team of Rasashastra - Chemistry –
Botany – Pharmacy – Ayurveda Specialized
Branch - are together to work on a
compound – unbiased
– Various methods of said preparations are
compared for the – structure – safety
(Toxicity) – economy - efficacy –

22


Polynomial Research

• It is defined as - A mathematical function that is
the sum of a number of terms –
– As the standards of the Ayurveda are unique and not
fit to the “Rest of the World” –
• A multi center – large sample – uni-directional studies are
invited
– This is possible by the universities or CCRAS or ICMR –
creating a Nodal officer to control the studies all over – even the
PG Centers
• A common minimum policy is created to ensure
the
– Drug Safety
– Half life
– Target area and
– Excretion
23


Reverse Pathology – Reverse Pharmacology

• Reverse pathology in Ayurveda is said as – Samprapti
Vighatana
• Planning of the Vighatana with the combination is the
most important task in Ayurveda Practice. It is possible
with the understanding of Ayurveda principles and
application of –
– Rasa
– Guna
– Veerya
– Vipaka
– Prabhava
• Reverse Pharmacology is understood under the present
day technology about –
– Drug Excretion
– Drug target
– Half life, etc
24


Example • Madhumeha patho-physiology is –
• Bahumootrantaka Ras – Tissues of body are liquidated -
used in Madhumeha has – – The sugar reserves undertakes neo-
• Ahiphena glucogenesis
• Dadima – Non utilization of CHO by muscles or
• Kadali even for transformation in to deposits
• Parad – Free CHO (Shareera Kleda) mix with
• Loha fluids (Ap Dhatu) of the body
• Mouktika especially Rakta
• Praval – Expresses as “Bahudrava shleshma
• Shalmali yukta – Madhurakta”
• Udumbara – The liquids mixed with CHO of the
• Vanga body are transported to the KUB –
termed as - Madhumeha
– i.e. Elimination of excess fluids along
with Shareera Kleda (Glucose)
– The reverse pathology planned on
these grounds are – in RED – &
– Fluid Regulation
– CHO Regulation
25


Repatriation Hypothesis i.e. Reverse Pathology Fluid Regulation
Ahiphena paralyzes Same time the Urine re-
sigmoid smooth absorption from Henley's loop
mussels & Dadima is retarded by Vanga, and
prevents the fluid Kadali 2
re absorption from - Udumbara makes the
colon by reverse integumentary system
peristalsis, Loha (Lasika) to constrain and fluid
require maximum retained is drained back to
fluid for synthesis system
and absorbs the
water once again –
so, the fluid re-
entry in to system
is regulated at the 1
same time Shalmali
absorbs the fluid in
the colon

26


Repatriation Hypothesis i.e. Reverse Pathology CHO Regulation

Formation of shareera CHO combustion is done
kleda – CHO is through rapid muscle
through Liver (Mamsa movements by initiating
Khanda) and Acetylcholine at motor
Pancreas – there by endplates in muscle fiber
the Parada acts as 3 through - Mouktika –
agent to and prevents Pravala
the neo-glycolysis Heat generated with
muscle movement makes
the bahudrava shleshma
to evaporate

5 4
Shalmali, Parada
initiates the
pancreas to regulate
the CHO
27

Activity in Research Research Methods to Adopt Research Models GAP in Research

GAP Research Models

• General Ayurveda Practitioners Research
models are with –
– Involved Data base recording and
– submission to the nearest center for analysis –
as a part of big survey
• Suggesting the center for –
– epidemic and endemic events and
– actively participating in Health campaigns with
– Evidence based Research drugs provided by
the center in time
28

Activity in Research Research Methods to Adopt Research Models GAP in Research

GAP Research Models

• Area specific diseases are submitted and a common drug
therapy modules are adopted as per the centers advise
• Center responsibilities -
– Periodical CME for the practitioners with in 50 -100 KM
diameter
– Door to door survey of health / disease conditions
– Providing Easy access to the people about pro and
cant's of drug
– Life line access through telephone / Internet in
Institutional / Hospital centers
– Radio talks / TV shows / FM Radio services organized
to create Awareness to the Local people
29


Responsibilities of Practitioner

• Reclassify the usage of Rasaaushadhi in
– Infectious
– Metabolic
– Emergencies, etc
• Diseases of attention
– AIDS
– Cancer
– ED
– Paralysis
• Developing the databank for EB Ay Medicine
• Defining the Rasaushadhi in Departmental use –
Shalya, Prasuthi, etc.
• Suggestion of Contribution required in practice
• Ethical practices in Rasa practice
30


Conclusion
• The Interference of too many or
• No involvement
– is the problem in Ayurveda Research
• Developing Teamwork instead & Working
Unbiased in the Research and incorporating
Rasaaushadhi vividly in General Ayurveda Practice
are the solutions for development - because ….
–आरोग्यम ् (रस) भाःकरािदच्छे त ्

31

Excellence of Rasaaushadhi In Ayurveda Practice – Part 2

technoayurveda@gmail.com

THANK YOU
Dr. K. Shiva Rama Prasad
Of . . . technoayurveda.wordpress.com It’s
on
Technoayurveda International
Presentation
Dr. K. Shiva Rama Prasad, Professor & Head, Kayachikitsa, Amrita School of Ayurveda, Kerala 32

Excellence of Rasaushadhi research

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