This explains the molecular level of Ayurveda presented on 14-03-2018 at MHACGHRC, Wardha by DR KSR Prasad

1. Cellular Panchakarma
(M l l P h k )(Molecular Panchakarma)
KSR Prasad
P f P h kProfessor, Panchakarma
@MGAC, Wardha on 14‐03‐2018
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/

2. Introd ction
Cellular / Molecular Panchakarma
Introduction
• Ayurveda Panchakarma is a needAyurveda Panchakarma is a need
based, body end product toxic
deposition elimination methoddeposition elimination method
adopted physiology and natural
available resources to removeavailable resources to remove
depositions of unwanted toxins
naturally under controllednaturally under controlled
therapeutic procedures.
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 1/16

3. Gross & Molec lar Panchakarma
Cellular / Molecular Panchakarma
Gross & Molecular Panchakarma
• The Dosha explanation in presentThe Dosha explanation in present
scenario is easy when we
understand physiology of
contemporary using the applied
aspects of Ayurveda
• If only looking at the literary
translations of Sanskrit verses of
A d i i dlAyurveda, its output is endless
debatable
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 2/16

4. Macro Panchakarma
Cellular / Molecular Panchakarma
Macro Panchakarma
• It is well known fact that the bodyIt is well known fact that the body
is divided in to 3 segments –
– Thorax – Kapha ‐ Vamana– Thorax – Kapha ‐ Vamana
– Upper abdomen – Pitta ‐ Virechana
Lower abdomen Vata Vasti– Lower abdomen – Vata – Vasti
– And the upper part body i.e. Head ‐
NasyaNasya
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 3/16

5. Micro or Cell lar Panchakarma
Cellular / Molecular Panchakarma
Micro or Cellular Panchakarma
• In the body, cell is a unit structure y,
• The evaluation of multi cellular
organisms is a boon and has many
systems involved in itsystems involved in it
• The cell is independently active and
performs all activities of livingperforms all activities of living
organism
• Cell has Respiratory, Digestive
(i ) C di l ( b li )(input), Cardiovascular (metabolic),
Urinary (output), Reproductive, etc.
systems as in ‐ Amoebay
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6. Principles of Cell f nctions
Cellular / Molecular Panchakarma
Principles of Cell functions
1. Fluid (Ap dhatu) and it is distribution in ( p )
side cell (ICF) out side cell (ECF) and also
in between (IF)
2 H d H i t i t t f t2. Hydrogen ‐ pH is most important factor
to decide the diffusion and
permeability (Pitta)p y ( )
3. Electrolytes – Na, K, and Cl creates and
maintains membrane potential (Vata)
4. Apart from mitochondria, lysosomes,
ribosomes, genetic material and many
more are involved (Kapha)more are involved (Kapha)
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 5/16

7. Li in ith Vata
Cellular / Molecular Panchakarma
Living with Vata
• ORGANIZATIONORGANIZATION
• IRRITABILITY
• CONTRACTILITY• CONTRACTILITY
• NUTRITION
METABOUSM AND GROWTH• METABOUSM AND GROWTH
• RESPIRATION
• EXCRETION
• REPRODUCTION
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 6/16

8. Tridosha in Cell
Cellular / Molecular Panchakarma
Tridosha in Cell
• Body is with Four basic elements y
• Hydrogen [9.5]
• Oxygen [65.0]
– H and O together becomes water and
the source of Transportation = Vata
• Carbon [18 5]• Carbon [18.5]
– CHO is the source of carbohydrates and
Lipids that are energy sources = Pitta
• Nitrogen [3.2]
– CHON is the source of proteins and
builds the protoplasm = Kaphabuilds the protoplasm Kapha
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 7/16

9. Elemental Dhat components
Cellular / Molecular Panchakarma
Elemental Dhatu components
• CHO is the nutrient and Rasa – do give only Under or Over
nutritional effects
• Chlorine (Cl) [0.2]
• Sodium (Na) [0.2]
• Potassium (K) [0.4]
Important constituents of body fluids to make transportation (Rasa– Important constituents of body fluids to make transportation (Rasa
gati under khalekapota nyaya)
• Calcium [1.5]
• Phosphorous [1.0]
• Iron [0.1]
– Components of Blood (Rakta)
• Mamsa – Ca, K, Na, Magnesium, Iodine and Sulphur
M d CHO f R• Meda – CHO of Rasa
• Asthi – Ca, P, S
• Majja ‐ Mg, I
• Sukra Zn• Sukra – Zn,
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 8/16

10. Components infl ence Dosha
Cellular / Molecular Panchakarma
Components influence Dosha
• Apart from all –
– Electrical potentials
– Messengers
– Secretary enzymes
– Signaling mechanisms g g
– and many more …..
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11. Cell
Cellular / Molecular Panchakarma
Cell
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12. Waste b prod cts of Cell
Cellular / Molecular Panchakarma
Waste byproducts of Cell
• Energy =
• Lactic acid fermentation –
• CO2 is excreted from the cell –
Up to 7% in blood plasma– Up to 7% in blood plasma.
– About 70‐80% is hydrocarbonate ions,
– The remainder in RBC carried to lungs
• Nitrogenous Wastes
• ammonia, which raises the pH of body
fluids
– Converts in to Urea (BUN)
( ) b– uric acid (antioxidant) but cause
inflammation
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13. Hea Metals
Cellular / Molecular Panchakarma
Heavy Metals
• Arsenic, cadmium, copper, lead, mercury, zinc
and Aluminum (not a heavy)
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14. Cell To icit
Cellular / Molecular Panchakarma
Cell Toxicity
Category System affected Common symptoms
respiratory
nose, trachea,
lungs
irritation, coughing, choking, tight chest
shwasa
gastrointestinal stomach, intestines nausea, vomiting, diarrheag g
renal kidney
back pain, urinating more or less than
usual
headache dizziness behavior confusion
neurological brain, spinal cord
headache, dizziness, behavior confusion,
depression, coma, convulsions
hematological blood anemia (tiredness, weakness)
dermatological skin, eyes rashes, itching, redness, swelling
reproductive
ovaries, testes,
fetus
infertility, miscarriage
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 13/16

15. Nitro en astes
Cellular / Molecular Panchakarma
Nitrogen wastes
1. Ammonia (NH3) ‐ Most ammonia in the
b d f h i i b k d bbody forms when protein is broken down by
bacteria in the intestines . The liver normally
converts ammonia into urea
2. Urea ‐ It requires 0.05 L of water to excrete
1 g of nitrogen,
3 Uric acid – it is the least soluble in water3. Uric acid it is the least soluble in water
and can be stored in cells and body tissues
without toxic effects
4 C ti i it i b d t f l4. Creatinine ‐ it is byproduct of muscle
metabolism signifies impaired kidney
function, effective at killing bacteria
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 14/16

16. Other astes
Cellular / Molecular Panchakarma
Other wastes
1. CO2 is a waste product of Respiration
2 Nitrates and nitrites are wastes produced by2. Nitrates and nitrites are wastes produced by
nitrifying bacteria, just as sulfur and sulfates are
produced by sulfur‐reducing bacteria and sulfate‐
reducing bacteria.
3. Insoluble iron waste can be made by iron bacteria
by using soluble forms.y g
4. Solid waste products may be manufactured as
organic pigments derived from breakdown of
pigments like hemoglobin and inorganic salts likepigments like hemoglobin, and inorganic salts like
carbonates, bicarbonates, and phosphate,
whether in ionic or molecular form, are excreted
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/
as solids.[3]
15/16

17. Sta es of Elimination
Cellular / Molecular Panchakarma
Stages of Elimination
1. The stage of accumulation g
(Sanchaya)
2. Stage of augmentation (prakopa)
Disease
3. Stage of adherence (snehana)
4. Stage of migration (Anupravana)
f ICF t IF (Bl d)
Shakha
Prasarana
from ICF to IF (Blood)
5. Stage of transportation to
Koshta (Swedana)
Koshta Gata Dosha
Koshta (Swedana)
6. Stage of elimination (shodhana)
‐ Vamana, Virechana, Niruha Vasti
Shodhana
, ,
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/ 16/16

18. Thank o
Cellular / Molecular Panchakarma
Thank you
Dr. K. Shiva Rama Prasad, at http://www.technoayurveda.com/