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[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DIFFERENTIALS FOR MULTIPLE CAVITARY LESIONS
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LOOKING  AT  CAVITIES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
INVESTIGATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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FNAC OF A NODULE(CT GUIDED)
 
POSSIBILITIES ,[object Object],[object Object]
P-ANCA … POSITIVE Approximately 90% of patients with active Wegener’s granulomatosis have a positive antiproteinase-3 ANCA. A small percentage of patients with Wegener’s granulomatosis may have antimyeloperoxidase rather than antiproteinase-3 antibodies.
Points in favour ,[object Object],[object Object],[object Object],[object Object]
Wegener  granulomatosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Wegener  granulomatosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ANCA ,[object Object],[object Object],[object Object],[object Object]
Kallenberg CGM  et al.  (2006) Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides  Nat Clin Pract  Rheumatol   2:   661 – 670  doi:10.1038/ ncprheum0355 Figure 1  Cytoplasmic components of ethanol-fixed neutrophils, stained by indirect immunofluorescence, in a serum sample from a patient with active Wegener's granulomatosis and antineutrophil cytoplasmic autoantibodies to proteinase 3
RENO-PULMONARY SYNDROMES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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Imaging: Multiple Pulmonary Cavitary Lesions

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  • 17. FNAC OF A NODULE(CT GUIDED)
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  • 20. P-ANCA … POSITIVE Approximately 90% of patients with active Wegener’s granulomatosis have a positive antiproteinase-3 ANCA. A small percentage of patients with Wegener’s granulomatosis may have antimyeloperoxidase rather than antiproteinase-3 antibodies.
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  • 25. Kallenberg CGM et al. (2006) Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides Nat Clin Pract Rheumatol 2: 661 – 670 doi:10.1038/ ncprheum0355 Figure 1 Cytoplasmic components of ethanol-fixed neutrophils, stained by indirect immunofluorescence, in a serum sample from a patient with active Wegener's granulomatosis and antineutrophil cytoplasmic autoantibodies to proteinase 3
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