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A Case of Thalassemia

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Stanley Medical College, Department of Medicine
Salud y medicina
1 de 50
Case of the week Jagdish K Prof. A. Gowrishankar’s unit
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Investigations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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THAL MAJOR THAL MINOR THAL INTERMEDIA < 2 yrs; asymptomatic variable Transfusion dependent asymptomtic variable Hb 2-3 g at presentation Rarely < 9 variable Hb F > A2 > A Hb F < 5 % Same as major Florid clinical manifestations asymptomatic variable
Diagnosis ,[object Object]
Hemoglobin ,[object Object],[object Object],[object Object],[object Object],[object Object]
Thalassemia ,[object Object],[object Object],[object Object],[object Object]
β thalassemia ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Homo tetramer Precipitates in RBC Destroyed in marrow Not soluble Destroyed in spleen Ineffective erythropoiesis Extravascular hemolysis
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Anemia & thalassemia ,[object Object],[object Object],[object Object]
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Take home messages ,[object Object],[object Object],[object Object]
Thank you!!!

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A Case of Thalassemia

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  • 19. THAL MAJOR THAL MINOR THAL INTERMEDIA < 2 yrs; asymptomatic variable Transfusion dependent asymptomtic variable Hb 2-3 g at presentation Rarely < 9 variable Hb F > A2 > A Hb F < 5 % Same as major Florid clinical manifestations asymptomatic variable
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