28. DD of sjogren’s HIV infection & sicca syndrome sjogren’s syn. sarcoidosis Age predominantly young males predominantly in middle-aged women invariable Auto-antibodies - Presence of autoantibodies to Ro/SS-A and/or La/SS-B - Histology lymphoid infiltrates of salivary glands by CD8+ lymphocytes Lymphoid infiltrates of salivary glands by CD4+ lymphocytes granulomas in salivary glands Genetics Associated with HLA-DR5 Associated with HLA-DR3 & DRw52 unknown Serology Positive tests for HIV Neg. tests Neg. tests