2.  ACH is a major neuro-humoral transmitter

3. ATP+ACETATE+CO ENZ-A
ACETYL CO ENZ-A
CHOLINE
ACETYL CHOLINE+CO ENZ-A
ACETYLCHOLINE CHLORIDE

4. It is of two types
1. MUSCARINIC
2. NICOTINIC

5.  These are selectively stimulated by
muscarine and blocked by atropine
 They are of five types-m1,m2,m3,m4,m5…

6. Location
CNS-Memory
GASTRIC GLANDS-HISTAMINE release
NATURE-G PROTEIN COUPLED
AGONIST-Oxotremorine

7.  Location –
CNS- tremor,analgesia
Visceral smooth muscles-contraction
 Nature
G-protein coupled
 Agonist - methacholine

8.  Location
Visceral smooth muscles- contraction
Iris-contraction of pupil
 Nature –g protein coupled
 Agonist:
bethanechol

9.  They are selectively activated by nicotine and
blocked by tubocurarine
 It is of two types Nm and Nn

10.  Location –CNS – specific inhibition and
excitation
 Nature- has intrinsic ion channel
 Agonist -nicotine

11.  Location –Nm junction- contraction of
skeletal muscles
 Nature – has intrinsic ion channel
 Agonist -nicotine

12.  These are drugs which produces action
similar to Ach.
 CHOLINERGICAGONISTS-
 CHOLINE ESTERASE-
Ach,methacholine,carbachol
 ALKALOIDS-muscarine,pilocarpine,arecoline

13.  A.MUSCARINIC
1. HEART-Ach hyper polarizes the SA nodal
cells and decreases rate of diastolic
depolarization.
It produces bradycardia.
 2. BLOODVESSELS-all are dilated.
it results in fall in BP

14.  3. smooth muscles-most organs are
contracted.
Peristalsis is increased in ureter.
 4. GLANDS- it results in increased sweating
,salivation and gastric secretion.
 5.EYE -contraction of ciliary muscle
Spasm of accomodation,reduces intra-
occular tension.

15. B. NICOTINIC
 1. Autonomic ganglia-both ganglias are
stimulated.
 High dose of Ach given after atropine causes
tachycardia
 2.skeletal muscles-intra arterial inj of high
dose cause twitching

16.  It is used to terminate paroxysomal
supraventricular tachycardia.

17.  1. INVOLUNTARY URINATION
 2.FLUSHING
 3.SWEATING
 4.FALL IN BP
 5.BRONCHO SPASM