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Diagnostic Modalities
For
Esophageal Diseases
Dr SD Sanyal
Modalities
1. Barium swallow
2. Esophagoscopy
3. Esophageal manometry/ Impedance
manometry
4. Ambulatory pH monitoring
5. Impedence pH monitoring
6. Endoscopic esophageal ultrasound
7. Bilitec 2000
Anatomy
• The oesophagus begins at the upper
oesophageal sphincter at the level of C6 and
finishes at lower oesophageal sphincter at T11
and is approx 25 cm
Constrictions
Barium Swallow
• Imaging procedure used to examine upper GI
tract,which include the esophagus and to a
lesser extent the stomach.
• Contrast : Barium sulphate
Indications
• Dysphagia
• Heart burn, retrosternal pain, regurgitation &
odynophagia.
• Hiatus hernia
• Reflux oesophagitis
• Stricture
• Esophageal carcinoma.
Indications
• Motility disorders:
i. Achalasia
ii. DES
• Pressure from Extrinsic lesions.
• Assessment of abnormality of:
• i. Zenkers diverticulum
• ii. Cricoid webs
• iii. Cricopharyngeal Achalasia.
Contraindications
• Suspected mediastinal/pleural/peritoneal leak
• Tracheo-esophageal fistula
Contrast Agent
• 100% BARIUM SULPHATE PASTE
• 80% BARIUM SULPHATE SUSPENSION
• 30% BARIUM SULPHATE SUSPENSION FOR
HIGH KV TECHNIQUE
• 200-250% HIGH DENSITY,LOW VISCOSITY FOR
DOUBLE CONTRAST STUDY
Views
• SOFT TISSUE NECK – AP & LAT – SCOUT
• NECK-AP & LATERAL
• THORAX-RAO VIEW
Types of Study
• Air esophagogram
• Full coloumn
• Mucosal relief
Scout film
RAO view
Preparation
• NPO
• Check for contrast related allergy
• Pregnancy
• Pre-procedure counselling
Technique
• PHARYNX
- One mouthful contrast bolus with high
density(250% w/v).
- Patient is asked to swallow once and stop
swallowing there after.
- This is to get optimum mucosal coating.
- Frontal and lateral view x-ray taken
Technique
• ESOPHAGUS
- Single contrast
- Multiple mouthfuls of 80% w/v barium
suspension
- Prone swallow to assess esophageal
contraction.
- Useful in esophageal
compression/disordered motility
Technique
• Double contrast
- Contrast high density,low viscosity(200-250%).
- 15-20 ml
- Effervescent powder given with another
mouthful of barium.
- In erect posture
• Pre-procedure administration of anti-spasmodic
Images
Air Contrast
Relief Contrast
Full Coloumn
Normal Indentations
Ca Esophagus
Achalasia cardia
DES
Webs
Hiatus Hernia
Gastro-esophageal Reflux
Gastro-esophageal Reflux
Esophageal Stricture
Barrett’s Esophagus
Zenker’s Diverticulum
Killian’s Dehiscence
Candida Esophagitis
Feline Esophagus
Esophagoscopy
• It is a modality to visualise the esophagus b/w
the:
- Upper esophageal sphincter
&
- GEJ
• Mostly performed as a part of esophago
gastroscopy
Types
- Based on the scope used:
• Rigid
• Flexible
Types
• Chromoendoscopy
• Magnification endoscopy
• Narrow band imaging
• Optical coherence tomograph spectroscopy
using:
- reflectance
- absorption
- light-scattering
- fluorescence
- Raman detection methods
Routes
• Trans-oral
• Trans-nasal
Indications
• Food bolus/ foreign body impaction
• Evaluation and management
of GERD, including noncardiac chest pain.
• Screening and surveillance of Barrett’s
Esophagus
• Treatment and surveillance of Esophageal
varices
Indications
• Evaluation and management
of Dysphagia including dilatation of
esophageal strictures
• Evaluation and management of Odynophagia
• Evaluation and management of esophageal
cancer, including placement of esophageal
stents
• Evaluation of the esophagus after abnormal
imaging studies
Contraindications
• Absolute:
- Hemodynamic instability
- Possibility of perforation
• Relative:
- Anticoagulation in the appropriate setting (ie,
esophageal dilation)
- Head and neck surgery
- Pharyngeal diverticulum
Technique
• Full history & examination.
• Focus on oral cavity and pharynx, thyroid gland,
cervical and supraclavicular lymph nodes.
• Position : Left lateral decubitus position.
• Moderate sedation: narcotic + bzd.
• Scope inserted into the oropharynx with
visualization of epiglottis and vocal cords.
• Scope advanced through pyriform sinuses and
esophageal lumen.
• Air insufflation
Complications
• Bleeding.
• Infection.
• Perforation.
• Aspiration.
• Over sedation.
• Hypoventilation.
• Cervical sepsis.
• Dental injury.
Images
Normal Proximal Esophagus
Endoscopic landmarks
Barrett’s Esophagus
Short Segment Barrett’s
Long Segment Barrett’s
Esophagitis
Esophagitis
CA Esophagus
CA Esophagus
Eosinophilic Esophagitis
Nissen’s Fundoplication
Nissen’s Fundoplication
Magnification Esophagoscopy
(Acetic Acid)
Magnification Esophagoscopy
(Narrow Band Spectroscopy)
Magnification Esophagoscopy
( Indigo Carmine)
Manometry
Definition
• Test devised to monitor:
- LES pressures
- Esophageal peristalsis
Device
• Flexible catheter with pressure sensors placed
at 5cm intervals
• It may :
- Contain water
- Be perfused
- Solid state
Indications
• Primary motility disorders of the esophagus
• In GERD for planning surgery
Measurements &Technique
• Assessment of LES:
- Mean resting pressure
1. Station pull through: 12-30mmHg
2. Rapid pull through: Higher pressures
due to artefacts
- Also provides information regarding:
1. Total length
2. Intra-abdominal length
3. Location of the sphincter wrt the nares
Measurement & Techniques
• Esophageal body:
- To assess the effectivity of peristalsis
- Specific parameters:
1. Peristaltic activity: percentage of initiated
swallows that transmitted successfully. Normal
>80%
2. Amplitude: Avg of pressures generated at
the distal end of the esophagus while
transmitting the peristaltic waves. Normal
>30mmHg
Measurements &Technique
• Technique:
- 4 channels placed at 3, 8, 13, 18 cms from
LES
- Atleast 10 series of 5ml aliquots of water
swallowed
High Resolution Impedence
Manometry
• Combination of pressure tomography with
impedance testing
• Advantages:
- Greater accuracy
- Effective continuous recording of motor activity
along the entire length of the esophagus
- No pseudorelaxation
• Colour contour plot with:
- time: X Axis
- esophageal length: Y Axis
pH Monitoring
Definition
• Technique to identify as well as quantify acid
reflux over a period of 24 hrs
• Technique:
-
Technique
• Catheter containing one or more solid-state
electrodes in the esophagus
• Electrodes are spaced 5 to 10 cm apart
• Sense fluctuations in the pH between 2 and 7
• Electrodes are connected to a data recorder
that the patient wears for the period of
observation
• There is a digital clock displayed on the
recorder
Indications
• Regurgitation
• Chest pain
• Cough
• Heartburn
• GERD
Information obtained
1. Total number of episodes
2. Longest episode of reflux
3. Episodes> 5mins
4. Extent of reflux in upright and supine
positions
Interpretation
1. De Meester’s Score > 14.7
2. Total % of time pH < 4:
- Proximal: 1%
- Distal: 4%
3. Correlation of symptom diary with reflux
episodes
De Meester’s Score
Impedance pH monitoring
• Basis:
- Detection of reflux events based on a change
in resistance to flow of an electrical currents
b/w electrodes
- Impedance decreases with air and increases
with a liquid bolus
Impedance pH monitoring
• Advantages:
- Differentiates b/w acidic and alkaline reflux
- Estimation of the proximal extent of reflux
- Distinction b/w true reflux and the ingestion
of an acidic liquid
• Disadvantage:
- Over estimation of the number of reflux
episodes
- Availability
Impedance pH monitoring
• Indication:
- Pts with symptoms despite PPI therapy and
normal distal acid exposure on standard pH
monitoring
Bilitec 2000
Basis
• Patent of Medtronic
• Using bilirubin as a marker for bile it records
the frequency and duration of bile exposure in
either the stomach or the esophagus over 24
hrs
• Works on the principle of Spectrophotometry
Indications
1. Pts with typical reflux symptoms, who do not
successfully respond to therapy and are not
affected by esophagitis at endoscopy
2. Atypical symptoms and normal endoscopy
3. Patients on follow-up after medical and
surgical therapy
Endoscopic Esophageal
Ultrasound
Technology
• Based on the “Pulse Echo Technique”
• Aka B Mode/ Gray scale ultrasonography
• Fast frame display: 12 images / second
• Transducer frequencies b/w 5-20 MHz
• 360 degree sector scan perpendicular to the
transducer tip
• Soft tissue penetration b/w 3-12 cms
Technique
• Production of acoustic interface b/w
transducer and tissue:
- Water filled balloon
- Transient filling of esophagus with water
• Radial mechanical blind probe for the
assessment of esophageal strictures
Indications
• Carcinoma esophagus
- Initial staging
- EUS guided FNAC of LN’s
- Post RT staging
• Benign tumours
• Esophageal cyst
• Achalasia cardia
• Varices
EUS Anatomy
Images
Ca Esophagus (T staging)
Ca Esophagus (N Staging)
Ca Esophagus( Hepatic mets)
Leiomyoma
Foregut Cyst

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Esophagus diagnostic: modalities