This presentation deals with buprenorphine drug profile, from a clinical pharmacist perspective.
Summarized version of drug, including chief ADRs, interactions, and patient and health-care professional counselling tips have been mentioned.
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Buprenorphine drug profile by Dr. Vishnu!
1. DR. VISHNU R NAIR,
PharmD, Dip. (Neuroplasticity), Dip. (Keto Dietary Advisor), Dip.
(Psychotherapy), Nutrition Coach,
Assistant Professor (Dept. of Pharmacy Practice),
NIMS Institute of Pharmacy, NIMS University.
2. Drug opioid in nature mandates prescription use of drug!
Comes under “controlled substance”
11. Respiratory depression (especially in overdose)
QTc- prolongation risk of Torsades de pointes!
Hepatotoxicity:
• Drug CV collapse shock ischemic liver injury liver
damage!
Severe allergic reactions!
12. Drug + CNS depressants (including alcohol) high risk of sedation & dizziness
Drug + CYP3A4 inhibitors (amiodarone, erythromycin, INH) reduced
metabolism of buprenorphine high risk of buprenorphine toxicity!
Drug + CYP3A4 inducers (Rifampin, CBZ, fosphenytoin) increased metabolism
of buprenorphine reduced efficacy of buprenorphine!
Drug + amiodarone, fluoroquinolones, erythromycin high risk of QTc-
prolongation high risk of Tdp!
Drug + MAO-inhibitors high risk of sedation!
13. Severe respiratory disease
Severe depression
Acute asthmatic attacks
Paralytic ileus:
- Drug impairs GI motility can worsen paralytic ileus!
If using transdermal patch:
- Management of mild, acute/intermittent pain
- Management of pain requiring short-term opioid analgesia
- Management of post-operative pain.
CNS depressive effects of
buprenorphine!
15. Never use drug with BZDs & CNS depressants :
- High risk of sedation, respiratory depression, coma & death!
Implants not used properly (inserted/ removed abruptly) high
risk of nerve damage / embolism be careful when inserting in upper
arm!
[Buprenorphine + naloxone] combination tablets preferred over
buprenorphine monotherapy for opioid dependence
- Naloxone unabsorbed opiate antagonist
- Naloxone blocks effects of buprenorphine reduces risk of
buprenorphine abuse!!
16. Patch dose> 20 µg/hr high risk of QTc-prolongation!
Drug lowers seizure threshold use cautiously in patients with
seizure history or currently under treatment!
17. Avoid alcohol consumption
Drug causes drowsiness impairs ability to focus, operate machinery
careful!
Drug may cause constipation report to physician/ pharmacist if it gets severe
Prolonged drug use high risk of physical/ psychological dependence use, only
as directed by physician/ pharmacist!
Do not place direct heat on patch!!!!!
Report any allergic reactions (especially with patches/ implants)
Never cut the patches by yourself!
Apply patches on hairless, dry area
Keep used & unused patches away from children!