4. 4
Personalized treatment can be achieved through building the end-to-end
analysis tool, which can perform the image analysis to Biomarker Analysis
to Gene Analysis to Blood Analysis of each patient to predict their response
to any therapy
Image Analysis
Bio-Marker
Analysis
Gene Expression
Analysis
Blood Analysis
A treatment should not be “one-fits-all” approach
Identify the patients who respond to the medicine based on their biomarkers
5. 5
http://www.applyscience.it/life-science-division/
<reference of image>
Reference: Nirschl, Jeffrey & Janowczyk, Andrew & Peyster, Eliot & Frank, Renee &
Margulies, Kenneth & Feldman, Michael & Madabhushi, Anant. (2018). A deep-learning
classifier identifies patients with clinical heart failure using whole-slide images of H&E
tissue. PLoS ONE. 13. 10.1371/journal.pone.0192726.
12. 12
Biomarker
Analysis
• Which Biomarkers are more effective for a patient to respond to the
therapy?
• Spatial Configuration of Biomarkers in a responding and non-responding
patients
14. 14
•
•
•
•
• *Units: Measurement scale to be obtained from CRO/medical team
• More generalized comparison can be done at responding non-responding patients level once sufficient data is provided