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Muscular Dystrophy &  
Myasthenia Gravis &
• Presented By – 
Prof.Dr.R.R.Deshpande 
(M.D in Ayurvdic 
Medicine & M.D. in 
Ayurvedic Physiology)
• www.ayurvedicfriend.c
om
• Mobile – 922 68 10 630
• professordeshpande@g
mail.com
12/19/2016 1Prof.Dr.R.R.Deshpande
Kayachikitsa -- Paper 2 Part A
Point 5
• Nidana and Chikitsa of Urusthambha
• Gullian Barrie syndrome 
• Muscular Dystrophy
•  Myasthenia Gravis
• Motor Neuron Diseases and Neuralgia 
• Neuralgia 
12/19/2016 2Prof.Dr.R.R.Deshpande
Myopathies
• Group of conditions having primary affections 
of muscles 
• Characterized by –
• Involvement of proximal muscle groups, 
Ultimate wasting, Absence of fibrillation 
bilateral involvement ,hereditary transmission, 
no involvement of nervous system ,downhill 
course, absence of remission 
12/19/2016 3Prof.Dr.R.R.Deshpande
Muscular Dystrophy
12/19/2016 4Prof.Dr.R.R.Deshpande
Muscular Dystrophy
• Several inherited disorders are included
• Characterized by progressive degeneration of
groups of muscles
• But no involvement of the nervous system
12/19/2016 5Prof.Dr.R.R.Deshpande
Muscular Dystrophy-Clinical Types
• 1. Duchenne type or Pseudo hypertrophic
type
• 2.Juvenile Scapulohumeral type of ERB
• 3 .Facioscapulohumeral Form ( Landouzy
Dejerine Form)
• 4 Distal Form (Gower’s)
12/19/2016 6Prof.Dr.R.R.Deshpande
Types of Muscular Dystrophy
12/19/2016 7Prof.Dr.R.R.Deshpande
Duchenne type or Pseudo
hypertrophic type
12/19/2016 8Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• Only in males
• Transmitted by a sex linked recessive gene 
• Females carry the disease through gene but 
males are victims 
• Disease starts in the first few years of life 
• First pelvic girdle muscles are affected & lastly 
there is involvement of shoulder girdle 
muscles 
12/19/2016 9Prof.Dr.R.R.Deshpande
Muscular Dystrophy -Inheritance
12/19/2016 10Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• In many cases ,to start with Pseudo
hypertrophy is seen in Gluteal region, Calf, 
Quadriceps, Deltoids, Infra spinatus muscles
•  Muscles look bulkier from outside but Motor 
power ,tone are less & jerks are dull .
12/19/2016 11Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• On voluntary contraction, the affected 
muscles do not become hard & globular .The 
firm fleshy feel is lost 
• At the same time of this Pseudohypertrophy 
some muscles also show atrophy. For 
example, Pectoralis major ,becomes so thin 
like parchment paper 
12/19/2016 12Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• In due course of time, all muscles, showing 
pseudoatrophy ,also become atrophic
• Then contractures are seen 
12/19/2016 13Prof.Dr.R.R.Deshpande
Symptoms of Muscular Dystrophy
12/19/2016 14Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• Due to weakness of the affected muscle 
group, patient cannot walk in a normal 
manner 
• He stands on a broad base, with a lordosis of
lumbar spine .Whole chest is thrown in a 
forward plane .During stepping patient swings 
this way & that ,simulating a duck
12/19/2016 15Prof.Dr.R.R.Deshpande
Gait in Muscular Dystrophy
12/19/2016 16Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• In the early stages, instead of this gait, patient 
may show, just a limping gait
• In the terminal stages ,when all the muscles 
are wasted ,patient can not stand erect .In an 
attempt to do ,this patient crawls on the 
ground .This is called as Frog like gait
12/19/2016 17Prof.Dr.R.R.Deshpande
Muscular Dystrophy –Gait
12/19/2016 18Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• When lying down position, when patient tries 
to get up ,he rolls over body 
• Then supports on the ground ,then on his feet 
& knees & then stands up ,as if he is climbing 
up his own body
•  
• This is called as Rising Test or Gower’s sign
This is characteristic feature of this disease
12/19/2016 19Prof.Dr.R.R.Deshpande
MD – Gower’s sign
12/19/2016 20Prof.Dr.R.R.Deshpande
1. Duchenne type or Pseudo hypertrophic type
• Due to weakness of shoulder girdle muscle, 
patient cannot hang by the support of his 
axillae & falls down
• Death occurs usually in the second decade 
from inanition or respiratory infection 
• Histologically, the affected muscles show
,few islands of muscle fibrils in a vast ocean
of fibrofatty tissue
12/19/2016 21Prof.Dr.R.R.Deshpande
Mnemonics for Muscular Dystrophy
12/19/2016 22Prof.Dr.R.R.Deshpande
Clinical features of Muscular Dystrophy
• symmetrical wasting & weakness
• No fasciculation 
• No sensory loss 
• Tendon reflexes are preserved ( Except in 
Dystrophia Myotonica) 
• Tendon reflexes are preserved until a late 
stage .
12/19/2016 23Prof.Dr.R.R.Deshpande
Differential Diagnosis –
of Muscular Dystrophy
• Based on – 
• Age at onset
• Distribution of affected muscles 
• pattern of inheritance
12/19/2016 24Prof.Dr.R.R.Deshpande
Investigations - of Muscular Dystrophy
• Diagnosis can be confirmed by EMG & muscle
Biopsy
• In Duchenne muscular dystrophy, Creatine
Kinase is markedly elevated
12/19/2016 25Prof.Dr.R.R.Deshpande
Dystrophia myotonica
• Dystrophia myotonica is diagnosed clinically 
by the distribution of muscle weakness & 
other features like myotonia (slow relaxation 
of muscle) ,cataract, Ptosis, frontal baldness 
Gonadal atrophy
• This is caused by expansion of a trinucleotide
repeat on chromosome 19 .Diagnosis is 
possible by measuring the number of repeats  
12/19/2016 26Prof.Dr.R.R.Deshpande
Dystrophia myotonica
• The genetic defects of Duchenne dystrophy & 
facioscapulohumeral dystrophy -- can be 
mapped to chromosomes Xp 21 & 4q 35, 
respectively
• DNA analysis may help in early diagnosis
• Pre natal testing in Dystrophia myotonica can 
also help 
12/19/2016 27Prof.Dr.R.R.Deshpande
Dystrophia myotonica
• Treatment – 
• No specific Therapy
• Physiotherapy & Occupational Therapy help 
the patient to cope with disability 
• Genetic counseling is important 
12/19/2016 28Prof.Dr.R.R.Deshpande
Prognosis of Duchenne Dystrophy
• Most patients with Duchenne Dystrophy die
within 10 years of diagnosis
• Life span of Limb girdle & facioscapulohumeral 
dystrophies is normal 
• Premature death occurs due to respiratory or 
cardiac failure in early middle age occurs in 
Dystrophia myotonica
12/19/2016 29Prof.Dr.R.R.Deshpande
Treatment for Muscular Dystrophy
12/19/2016 30Prof.Dr.R.R.Deshpande
2.Juvenile Scapulohumeral type of ERB
• This disease affects both genders 
• It is inherited as an Autosomal recessive
gene
• This is seen in 2nd & 3rd decade of life 
• But may occur at any age ,after first 5 
years 
12/19/2016 31Prof.Dr.R.R.Deshpande
2.Juvenile Scapulohumeral type of ERB
• Symptoms may begin in upper arms, in 
the shoulder girdle or in the pelvic girdle 
muscles
 
• Most patients are disabled within 20
years .Do not survive up to the middle
age
12/19/2016 32Prof.Dr.R.R.Deshpande
3 .Facioscapulohumeral Form
( Landouzy Dejerine Form)
• This affects both genders 
• Inherited as an Autosomal dominant
gene
• The muscles involved earliest are of face
• Then the disease progresses centrifugally 
to shoulder girdle & upper arms muscles
• Disablement occurs during puberty 
12/19/2016 33Prof.Dr.R.R.Deshpande
3 .Facioscapulohumeral Form
( Landouzy Dejerine Form)
• Facial weakness ( Myopathic facies )
exist for many years ,before the
development of weakness anywhere
• In advanced cases, Lordosis &Scoliosis 
develop
• Disease progress very slowly 
12/19/2016 34Prof.Dr.R.R.Deshpande
3 .Facioscapulohumeral Form
( Landouzy Dejerine Form)
• Most patients remain ambulatory until
middle or later life
• Contracture & Pseudo hypertrophy is 
absent 
• Sometimes Juvenile Scapulohumeral  
type & Facioscapulohumeral Form are 
together classified as Limb Girdle type
12/19/2016 35Prof.Dr.R.R.Deshpande
4 Distal Form (Gower’s)
• This is comparatively rare
• Distal muscles of the extremities are
first affected
• Then the disease proceeds centripetally
• Common in Scandinavia 
12/19/2016 36Prof.Dr.R.R.Deshpande
4 Distal Form (Gower’s)
• Disease starts between 30 & 50 years 
• Progress of the disease is slow 
• Patient usually disabled within a few
decades
12/19/2016 37Prof.Dr.R.R.Deshpande
Investigations for Muscular Dystrophy
• Aminoaciduria ,Pentosuria ,Creatinuria
are seen .But not specific 
• Aldolase , Phosphohexoisomerase 
Transminases are increased in blood ( But 
doubtful value in the diagnosis) 
12/19/2016 38Prof.Dr.R.R.Deshpande
Investigations for Muscular Dystrophy
• Specific change is increase in Creatin 
Kinase in the blood 
• Muscle Biopsy & Electromyography are
Confirmatory
12/19/2016 39Prof.Dr.R.R.Deshpande
Differential Diagnosis
of Muscular Dystrophy
• 1.Chronic Motor neurone disease –
•  In this condition fibrillation, muscular
wasting ,non symmetrical findings
negative family history ,evidences of 
pyramidal lesion are present 
12/19/2016 40Prof.Dr.R.R.Deshpande
Differential Diagnosis
of Muscular Dystrophy
• 2. Residual Poliomyelitis –
• There will be history of fever ,acute
onset asymmetrical ,non progressive
findings are seen 
12/19/2016 41Prof.Dr.R.R.Deshpande
Differential Diagnosis
of Muscular Dystrophy
• 3. Acquired Myopathies –
• Develop from various endocrinal 
disorders carcinomatosis & 
dermatomyositis.
• These cases may improve with steroid 
therapy
•  Also there may be spontaneous recovery 
12/19/2016 42Prof.Dr.R.R.Deshpande
Treatment of Muscular Dystrophy
• No Effective treatment is available
• General measures to improve health 
• Physiotherapy & orthopedic measures 
can help to overcome deformities & 
contracture 
12/19/2016 43Prof.Dr.R.R.Deshpande
Myasthenia Gravis
• Abnormal fatigue of striated muscles --
• Due to deficiency or abnormal behaviour 
of Ach at myoneural junction 
12/19/2016 44Prof.Dr.R.R.Deshpande
Myasthenia Gravis -Etiology
• Common at age 20 to 30 years .But occur 
exceptionally in new born .Females are
more prone
• This condition may be associated with – 
Thyrotoxicosis, Hashimoto’s disease, 
Rheumatoid arthritis, Carcinoma 
12/19/2016 45Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Etiology
• Exact cause of the disease not known
• In 15 % vases ,Thymic Tumour is present 
• The behaviour of Acetyl choline at the 
myoneural junction is seen abnormal 
12/19/2016 46Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Etiology
• Auto immune disorder
• Affecting 1 in 10,000 population .
• Due to development of antibodies directed to
nicotine receptors ( NR) at the muscle endplate
• Reduction in number of free N-M cholinoreceptors to 
1/3rd of normal 
• Structural damage to neuromuscular junction
•  Weakness & easy fatigability on repeated activity 
• Recovery after rest 
12/19/2016 47Prof.Dr.R.R.Deshpande
Pathology in Myasthenia Gravis
12/19/2016 48Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Clinical Features
• Characteristic symptom – 
• Abnormal fatigue of skeletal muscles
• They become rapidly tired 
• This tiredness is prominent at the end of 
the day 
12/19/2016 49Prof.Dr.R.R.Deshpande
Symptoms of Myasthenia Gravis
12/19/2016 50Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Clinical Features
• Muscles most commonly affected are – 
• Extra ocular, bulbar, neck & shoulder
girdle muscles
• Rarely the respiratory & pelvic girdle 
muscles are affected 
12/19/2016 51Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Clinical Features
• Earliest symptom is Ptosis & diplopia
which may be intermittent 
• There may be tiredness during chewing, 
swallowing, speaking & during 
movement of limbs 
• All symptoms may wax and wane from 
time to time 
12/19/2016 52Prof.Dr.R.R.Deshpande
Earliest Symptom in Myasthenia Gravis
12/19/2016 53Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Clinical Features
• Relapses are common after emotional 
upsets severe muscular exercises, 
pregnancy or in generalized infections 
• Paralysis of respiratory muscles can 
cause asphyxia & death 
• In chronic cases there may be atrophy of
involved muscles
12/19/2016 54Prof.Dr.R.R.Deshpande
Symptoms of Myasthenia Gravis
12/19/2016 55Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Diagnosis
• Ameliorative test –
• Edrophonium 2–10 mg injected slowly i.v.
improves muscle strength only in myasthenia 
gravis and not in other muscular dystrophies
12/19/2016 56Prof.Dr.R.R.Deshpande
Myasthenia Gravis - Diagnosis
• Ask the patient to look upwards 
continuously when gradually the upper 
eyelids will droop down
• Injection Prostigmin 2.5 mgm IM or 
Edropheonium hydrochloride 10 mgm IV 
can give quick relief to this fatigue 
12/19/2016 57Prof.Dr.R.R.Deshpande
Bedside Test for Myasthenia Gravis
12/19/2016 58Prof.Dr.R.R.Deshpande
Test for Myasthenia Gravis
12/19/2016 59Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• Neostigmine & it’s congeners improve muscle 
contraction, by allowing Ach released from 
prejunctional endings to accumulate & act on 
receptors over a larger area & by directly
depolarizing the end plate
• Treatment – Neostigmine 15 mg orally 6 hourly
.Dose & frequency is then adjusted according to 
response.
• However, the dosage requirement may fluctuate 
from time to time
12/19/2016 60Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• Pyridostigmine is an alternative which needs 
less frequent dosing
•  If Intolerable muscarinic side effects are 
produced, atropine can be added to block 
them.
12/19/2016 61Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• Corticosteroids afford considerable improvement in 
such cases by their immunosuppressant action.
• They inhibit production of NR-antibodies and may 
increase synthesis of NRs. 
12/19/2016 62Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• Prednisolone 30–60 mg/day induces
remission in about 80% of the advanced cases; 
10 mg daily or on alternate days can be used 
for maintenance therapy. 
• Other immunosuppressants have also been 
used with benefit in advanced cases. 
• Both azathioprine and cyclosporine also 
inhibit NR-antibody synthesis by affecting T-
cells
12/19/2016 63Prof.Dr.R.R.Deshpande
Treatment for Myasthenia Gravis
12/19/2016 64Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• Advice – Avoid fatigue ,Excess work,
Exercises
• Tab Prostigmin orally 15 to 45 mgm every 
2 to 4 hours 
• In severe cases – Inj Prostigmin 2.5 mgm 
IM may require 
12/19/2016 65Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• To minimize the effects this drug Inj
Atropine 0.6 mgm can be given ,20 min
before or --
• Propantheline bromide 15 mgm BD is 
given 
• Long acting drugs like Pyridostigmin ,may 
be given 
12/19/2016 66Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• Very large doses of Prostigmin may cause 
‘Cholinergic crisis’
• The symptoms are sweating, pallor, 
fasciculations, small pupil ,salivation 
• In this condition Inj Atropine must be 
given immediately 
12/19/2016 67Prof.Dr.R.R.Deshpande
Myasthenia Crisis
12/19/2016 68Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
• In respiratory distress ,Artificial Respiration 
should be given 
• Surgical Thymectomy ,can give permanent 
cure ( specially in young females & when 
disease is not more than 6 years duration 
• In patients with Thymoma ,x ray radiation is
given ,before operation
12/19/2016 69Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Treatment
 
• Thymectomy produces gradual improvement 
in majority of cases
• Thymus may contain modified muscle cells 
with NRs on their surface, which may be the 
source of the antigen for production of anti-
NR antibodies in myasthenic patients.
12/19/2016 70Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• This is Bala Kshaya ( Loss of strength) +
• Glani +
• Dhatu Kshatajanya Vata Prakop in Mansa 
Dhatu 
• Cause – Auto Immune Disease 
12/19/2016 71Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• Important Clinical features –
• Abnormal fatigue & initially weakness of
selected muscles i.e Eye, mouth, throat
• Facial expressions are affected 
12/19/2016 72Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• Muscle weakness worsens  with activity 
& improves with rest 
• Ptosis, Double vision ,Dysarthria,
Dysphagia
• Muscles temporarily paralysed 
• Breathing becomes difficult ,due to 
weakness of chest wall muscles 
12/19/2016 73Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• Investigations – 
• Ach receptor antibody in blood 
• Edrophonium test – IV Endrophonium chloride or 
Tensilon is given .This blocks degradation of Ach & 
temporarily increase the level of Ach at the 
neuromuscular junction 
• In the patient who have involved the eye muscles 
Endrophonium chloride will partially relieve 
weakness 
12/19/2016 74Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• Nerve conduction study is done
• CT scan can be used to detect abnormal 
Thymus gland or the presence of 
Thymone 
12/19/2016 75Prof.Dr.R.R.Deshpande
Myasthenia Gravis – Ayurved Treatment
• Avaranaghna chikitsa
• Dhatu Kshayajanya vata prakop chikitsa
• Mansa Kshaya chikitsa
• Bruhan ,Shramahar chikitsa
• Ushna chikitsa
12/19/2016 76Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• Tab Bruhatvat chitamani – 1 in morning
with 2 tsf Chavanprash
• Tab Bala Ghana vati 3 TDS with
Ashwagandharishta 4 tsf with equal
quantity of water
• Kshirbala tail 10 ml + Prasaranyadi Tail 10 
ml – with warm milk at night 
12/19/2016 77Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• External – 
• Abhyana – Dhanvantaram Kuzambu or 
Maha masha oil in the morning + 
Alternate day Abhyanga with Sahachar 
oil 
• Basti – Mustadi Rajyapan Basti 
• Nasya – Sahacharadi oil 
12/19/2016 78Prof.Dr.R.R.Deshpande
Almond oil for Myasthenia Gravis
12/19/2016 79Prof.Dr.R.R.Deshpande
Rajyapan Basti-Indications
• It is recommended in dry allergic cough or in
• COPDs like emphysema, bronchiectasis,
• chronic fever, gouty arthritis, irritable bowel
• syndrome, Knee joint osteoarthritis etc.
• It is used in Auto immune conditions like
• Ankylosing spondylosis & RA.
• Rajyapan Basti increases the strength, it
• increases the sexual drive, improves the
• digestion and Vital sap.
12/19/2016 80Prof.Dr.R.R.Deshpande
Rajyapan Basti-Ingrediants
•
• Decoction of Ashwagandha, Shatavari,
• Erandamool, Bala in a dose of 240 ml.
• Honey - 20 ml.
• Rock salt - 5 Gm
• Sesame oil - 40 ml
• Ghee - 40 ml.
• Meat soup – 160 ml & Cow Milk – 160 ml.
12/19/2016 81Prof.Dr.R.R.Deshpande
Myasthenia Gravis & Ayurved
• Eat – Milk , Almond, Garlic
• Avoid – Vata vruddhi kar Diet & Life style 
•              Excess dry & cold food 
• Avoid -- Hectic Life style
12/19/2016 82Prof.Dr.R.R.Deshpande
Prof.Dr.R.R.Deshpande
• Sharing of Knowledge 
• FOR 
• Propagating Ayurved
12/19/2016 83Prof.Dr.R.R.Deshpande

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Muscular Dystrophy & Myasthenia Gravis ppt

  • 1. Muscular Dystrophy &   Myasthenia Gravis & • Presented By –  Prof.Dr.R.R.Deshpande  (M.D in Ayurvdic  Medicine & M.D. in  Ayurvedic Physiology) • www.ayurvedicfriend.c om • Mobile – 922 68 10 630 • professordeshpande@g mail.com 12/19/2016 1Prof.Dr.R.R.Deshpande
  • 2. Kayachikitsa -- Paper 2 Part A Point 5 • Nidana and Chikitsa of Urusthambha • Gullian Barrie syndrome  • Muscular Dystrophy •  Myasthenia Gravis • Motor Neuron Diseases and Neuralgia  • Neuralgia  12/19/2016 2Prof.Dr.R.R.Deshpande
  • 3. Myopathies • Group of conditions having primary affections  of muscles  • Characterized by – • Involvement of proximal muscle groups,  Ultimate wasting, Absence of fibrillation  bilateral involvement ,hereditary transmission,  no involvement of nervous system ,downhill  course, absence of remission  12/19/2016 3Prof.Dr.R.R.Deshpande
  • 5. Muscular Dystrophy • Several inherited disorders are included • Characterized by progressive degeneration of groups of muscles • But no involvement of the nervous system 12/19/2016 5Prof.Dr.R.R.Deshpande
  • 6. Muscular Dystrophy-Clinical Types • 1. Duchenne type or Pseudo hypertrophic type • 2.Juvenile Scapulohumeral type of ERB • 3 .Facioscapulohumeral Form ( Landouzy Dejerine Form) • 4 Distal Form (Gower’s) 12/19/2016 6Prof.Dr.R.R.Deshpande
  • 7. Types of Muscular Dystrophy 12/19/2016 7Prof.Dr.R.R.Deshpande
  • 8. Duchenne type or Pseudo hypertrophic type 12/19/2016 8Prof.Dr.R.R.Deshpande
  • 9. 1. Duchenne type or Pseudo hypertrophic type • Only in males • Transmitted by a sex linked recessive gene  • Females carry the disease through gene but  males are victims  • Disease starts in the first few years of life  • First pelvic girdle muscles are affected & lastly  there is involvement of shoulder girdle  muscles  12/19/2016 9Prof.Dr.R.R.Deshpande
  • 11. 1. Duchenne type or Pseudo hypertrophic type • In many cases ,to start with Pseudo hypertrophy is seen in Gluteal region, Calf,  Quadriceps, Deltoids, Infra spinatus muscles •  Muscles look bulkier from outside but Motor  power ,tone are less & jerks are dull . 12/19/2016 11Prof.Dr.R.R.Deshpande
  • 12. 1. Duchenne type or Pseudo hypertrophic type • On voluntary contraction, the affected  muscles do not become hard & globular .The  firm fleshy feel is lost  • At the same time of this Pseudohypertrophy  some muscles also show atrophy. For  example, Pectoralis major ,becomes so thin  like parchment paper  12/19/2016 12Prof.Dr.R.R.Deshpande
  • 13. 1. Duchenne type or Pseudo hypertrophic type • In due course of time, all muscles, showing  pseudoatrophy ,also become atrophic • Then contractures are seen  12/19/2016 13Prof.Dr.R.R.Deshpande
  • 14. Symptoms of Muscular Dystrophy 12/19/2016 14Prof.Dr.R.R.Deshpande
  • 15. 1. Duchenne type or Pseudo hypertrophic type • Due to weakness of the affected muscle  group, patient cannot walk in a normal  manner  • He stands on a broad base, with a lordosis of lumbar spine .Whole chest is thrown in a  forward plane .During stepping patient swings  this way & that ,simulating a duck 12/19/2016 15Prof.Dr.R.R.Deshpande
  • 16. Gait in Muscular Dystrophy 12/19/2016 16Prof.Dr.R.R.Deshpande
  • 17. 1. Duchenne type or Pseudo hypertrophic type • In the early stages, instead of this gait, patient  may show, just a limping gait • In the terminal stages ,when all the muscles  are wasted ,patient can not stand erect .In an  attempt to do ,this patient crawls on the  ground .This is called as Frog like gait 12/19/2016 17Prof.Dr.R.R.Deshpande
  • 18. Muscular Dystrophy –Gait 12/19/2016 18Prof.Dr.R.R.Deshpande
  • 19. 1. Duchenne type or Pseudo hypertrophic type • When lying down position, when patient tries  to get up ,he rolls over body  • Then supports on the ground ,then on his feet  & knees & then stands up ,as if he is climbing  up his own body •   • This is called as Rising Test or Gower’s sign This is characteristic feature of this disease 12/19/2016 19Prof.Dr.R.R.Deshpande
  • 20. MD – Gower’s sign 12/19/2016 20Prof.Dr.R.R.Deshpande
  • 21. 1. Duchenne type or Pseudo hypertrophic type • Due to weakness of shoulder girdle muscle,  patient cannot hang by the support of his  axillae & falls down • Death occurs usually in the second decade  from inanition or respiratory infection  • Histologically, the affected muscles show ,few islands of muscle fibrils in a vast ocean of fibrofatty tissue 12/19/2016 21Prof.Dr.R.R.Deshpande
  • 22. Mnemonics for Muscular Dystrophy 12/19/2016 22Prof.Dr.R.R.Deshpande
  • 23. Clinical features of Muscular Dystrophy • symmetrical wasting & weakness • No fasciculation  • No sensory loss  • Tendon reflexes are preserved ( Except in  Dystrophia Myotonica)  • Tendon reflexes are preserved until a late  stage . 12/19/2016 23Prof.Dr.R.R.Deshpande
  • 24. Differential Diagnosis – of Muscular Dystrophy • Based on –  • Age at onset • Distribution of affected muscles  • pattern of inheritance 12/19/2016 24Prof.Dr.R.R.Deshpande
  • 25. Investigations - of Muscular Dystrophy • Diagnosis can be confirmed by EMG & muscle Biopsy • In Duchenne muscular dystrophy, Creatine Kinase is markedly elevated 12/19/2016 25Prof.Dr.R.R.Deshpande
  • 26. Dystrophia myotonica • Dystrophia myotonica is diagnosed clinically  by the distribution of muscle weakness &  other features like myotonia (slow relaxation  of muscle) ,cataract, Ptosis, frontal baldness  Gonadal atrophy • This is caused by expansion of a trinucleotide repeat on chromosome 19 .Diagnosis is  possible by measuring the number of repeats   12/19/2016 26Prof.Dr.R.R.Deshpande
  • 27. Dystrophia myotonica • The genetic defects of Duchenne dystrophy &  facioscapulohumeral dystrophy -- can be  mapped to chromosomes Xp 21 & 4q 35,  respectively • DNA analysis may help in early diagnosis • Pre natal testing in Dystrophia myotonica can  also help  12/19/2016 27Prof.Dr.R.R.Deshpande
  • 28. Dystrophia myotonica • Treatment –  • No specific Therapy • Physiotherapy & Occupational Therapy help  the patient to cope with disability  • Genetic counseling is important  12/19/2016 28Prof.Dr.R.R.Deshpande
  • 29. Prognosis of Duchenne Dystrophy • Most patients with Duchenne Dystrophy die within 10 years of diagnosis • Life span of Limb girdle & facioscapulohumeral  dystrophies is normal  • Premature death occurs due to respiratory or  cardiac failure in early middle age occurs in  Dystrophia myotonica 12/19/2016 29Prof.Dr.R.R.Deshpande
  • 30. Treatment for Muscular Dystrophy 12/19/2016 30Prof.Dr.R.R.Deshpande
  • 31. 2.Juvenile Scapulohumeral type of ERB • This disease affects both genders  • It is inherited as an Autosomal recessive gene • This is seen in 2nd & 3rd decade of life  • But may occur at any age ,after first 5  years  12/19/2016 31Prof.Dr.R.R.Deshpande
  • 32. 2.Juvenile Scapulohumeral type of ERB • Symptoms may begin in upper arms, in  the shoulder girdle or in the pelvic girdle  muscles   • Most patients are disabled within 20 years .Do not survive up to the middle age 12/19/2016 32Prof.Dr.R.R.Deshpande
  • 33. 3 .Facioscapulohumeral Form ( Landouzy Dejerine Form) • This affects both genders  • Inherited as an Autosomal dominant gene • The muscles involved earliest are of face • Then the disease progresses centrifugally  to shoulder girdle & upper arms muscles • Disablement occurs during puberty  12/19/2016 33Prof.Dr.R.R.Deshpande
  • 34. 3 .Facioscapulohumeral Form ( Landouzy Dejerine Form) • Facial weakness ( Myopathic facies ) exist for many years ,before the development of weakness anywhere • In advanced cases, Lordosis &Scoliosis  develop • Disease progress very slowly  12/19/2016 34Prof.Dr.R.R.Deshpande
  • 35. 3 .Facioscapulohumeral Form ( Landouzy Dejerine Form) • Most patients remain ambulatory until middle or later life • Contracture & Pseudo hypertrophy is  absent  • Sometimes Juvenile Scapulohumeral   type & Facioscapulohumeral Form are  together classified as Limb Girdle type 12/19/2016 35Prof.Dr.R.R.Deshpande
  • 36. 4 Distal Form (Gower’s) • This is comparatively rare • Distal muscles of the extremities are first affected • Then the disease proceeds centripetally • Common in Scandinavia  12/19/2016 36Prof.Dr.R.R.Deshpande
  • 37. 4 Distal Form (Gower’s) • Disease starts between 30 & 50 years  • Progress of the disease is slow  • Patient usually disabled within a few decades 12/19/2016 37Prof.Dr.R.R.Deshpande
  • 38. Investigations for Muscular Dystrophy • Aminoaciduria ,Pentosuria ,Creatinuria are seen .But not specific  • Aldolase , Phosphohexoisomerase  Transminases are increased in blood ( But  doubtful value in the diagnosis)  12/19/2016 38Prof.Dr.R.R.Deshpande
  • 39. Investigations for Muscular Dystrophy • Specific change is increase in Creatin  Kinase in the blood  • Muscle Biopsy & Electromyography are Confirmatory 12/19/2016 39Prof.Dr.R.R.Deshpande
  • 40. Differential Diagnosis of Muscular Dystrophy • 1.Chronic Motor neurone disease – •  In this condition fibrillation, muscular wasting ,non symmetrical findings negative family history ,evidences of  pyramidal lesion are present  12/19/2016 40Prof.Dr.R.R.Deshpande
  • 41. Differential Diagnosis of Muscular Dystrophy • 2. Residual Poliomyelitis – • There will be history of fever ,acute onset asymmetrical ,non progressive findings are seen  12/19/2016 41Prof.Dr.R.R.Deshpande
  • 42. Differential Diagnosis of Muscular Dystrophy • 3. Acquired Myopathies – • Develop from various endocrinal  disorders carcinomatosis &  dermatomyositis. • These cases may improve with steroid  therapy •  Also there may be spontaneous recovery  12/19/2016 42Prof.Dr.R.R.Deshpande
  • 43. Treatment of Muscular Dystrophy • No Effective treatment is available • General measures to improve health  • Physiotherapy & orthopedic measures  can help to overcome deformities &  contracture  12/19/2016 43Prof.Dr.R.R.Deshpande
  • 44. Myasthenia Gravis • Abnormal fatigue of striated muscles -- • Due to deficiency or abnormal behaviour  of Ach at myoneural junction  12/19/2016 44Prof.Dr.R.R.Deshpande
  • 45. Myasthenia Gravis -Etiology • Common at age 20 to 30 years .But occur  exceptionally in new born .Females are more prone • This condition may be associated with –  Thyrotoxicosis, Hashimoto’s disease,  Rheumatoid arthritis, Carcinoma  12/19/2016 45Prof.Dr.R.R.Deshpande
  • 46. Myasthenia Gravis - Etiology • Exact cause of the disease not known • In 15 % vases ,Thymic Tumour is present  • The behaviour of Acetyl choline at the  myoneural junction is seen abnormal  12/19/2016 46Prof.Dr.R.R.Deshpande
  • 47. Myasthenia Gravis - Etiology • Auto immune disorder • Affecting 1 in 10,000 population . • Due to development of antibodies directed to nicotine receptors ( NR) at the muscle endplate • Reduction in number of free N-M cholinoreceptors to  1/3rd of normal  • Structural damage to neuromuscular junction •  Weakness & easy fatigability on repeated activity  • Recovery after rest  12/19/2016 47Prof.Dr.R.R.Deshpande
  • 48. Pathology in Myasthenia Gravis 12/19/2016 48Prof.Dr.R.R.Deshpande
  • 49. Myasthenia Gravis - Clinical Features • Characteristic symptom –  • Abnormal fatigue of skeletal muscles • They become rapidly tired  • This tiredness is prominent at the end of  the day  12/19/2016 49Prof.Dr.R.R.Deshpande
  • 50. Symptoms of Myasthenia Gravis 12/19/2016 50Prof.Dr.R.R.Deshpande
  • 51. Myasthenia Gravis - Clinical Features • Muscles most commonly affected are –  • Extra ocular, bulbar, neck & shoulder girdle muscles • Rarely the respiratory & pelvic girdle  muscles are affected  12/19/2016 51Prof.Dr.R.R.Deshpande
  • 52. Myasthenia Gravis - Clinical Features • Earliest symptom is Ptosis & diplopia which may be intermittent  • There may be tiredness during chewing,  swallowing, speaking & during  movement of limbs  • All symptoms may wax and wane from  time to time  12/19/2016 52Prof.Dr.R.R.Deshpande
  • 53. Earliest Symptom in Myasthenia Gravis 12/19/2016 53Prof.Dr.R.R.Deshpande
  • 54. Myasthenia Gravis - Clinical Features • Relapses are common after emotional  upsets severe muscular exercises,  pregnancy or in generalized infections  • Paralysis of respiratory muscles can  cause asphyxia & death  • In chronic cases there may be atrophy of involved muscles 12/19/2016 54Prof.Dr.R.R.Deshpande
  • 55. Symptoms of Myasthenia Gravis 12/19/2016 55Prof.Dr.R.R.Deshpande
  • 56. Myasthenia Gravis - Diagnosis • Ameliorative test – • Edrophonium 2–10 mg injected slowly i.v. improves muscle strength only in myasthenia  gravis and not in other muscular dystrophies 12/19/2016 56Prof.Dr.R.R.Deshpande
  • 57. Myasthenia Gravis - Diagnosis • Ask the patient to look upwards  continuously when gradually the upper  eyelids will droop down • Injection Prostigmin 2.5 mgm IM or  Edropheonium hydrochloride 10 mgm IV  can give quick relief to this fatigue  12/19/2016 57Prof.Dr.R.R.Deshpande
  • 58. Bedside Test for Myasthenia Gravis 12/19/2016 58Prof.Dr.R.R.Deshpande
  • 59. Test for Myasthenia Gravis 12/19/2016 59Prof.Dr.R.R.Deshpande
  • 60. Myasthenia Gravis – Treatment • Neostigmine & it’s congeners improve muscle  contraction, by allowing Ach released from  prejunctional endings to accumulate & act on  receptors over a larger area & by directly depolarizing the end plate • Treatment – Neostigmine 15 mg orally 6 hourly .Dose & frequency is then adjusted according to  response. • However, the dosage requirement may fluctuate  from time to time 12/19/2016 60Prof.Dr.R.R.Deshpande
  • 61. Myasthenia Gravis – Treatment • Pyridostigmine is an alternative which needs  less frequent dosing •  If Intolerable muscarinic side effects are  produced, atropine can be added to block  them. 12/19/2016 61Prof.Dr.R.R.Deshpande
  • 62. Myasthenia Gravis – Treatment • Corticosteroids afford considerable improvement in  such cases by their immunosuppressant action. • They inhibit production of NR-antibodies and may  increase synthesis of NRs.  12/19/2016 62Prof.Dr.R.R.Deshpande
  • 63. Myasthenia Gravis – Treatment • Prednisolone 30–60 mg/day induces remission in about 80% of the advanced cases;  10 mg daily or on alternate days can be used  for maintenance therapy.  • Other immunosuppressants have also been  used with benefit in advanced cases.  • Both azathioprine and cyclosporine also  inhibit NR-antibody synthesis by affecting T- cells 12/19/2016 63Prof.Dr.R.R.Deshpande
  • 64. Treatment for Myasthenia Gravis 12/19/2016 64Prof.Dr.R.R.Deshpande
  • 65. Myasthenia Gravis – Treatment • Advice – Avoid fatigue ,Excess work, Exercises • Tab Prostigmin orally 15 to 45 mgm every  2 to 4 hours  • In severe cases – Inj Prostigmin 2.5 mgm  IM may require  12/19/2016 65Prof.Dr.R.R.Deshpande
  • 66. Myasthenia Gravis – Treatment • To minimize the effects this drug Inj Atropine 0.6 mgm can be given ,20 min before or -- • Propantheline bromide 15 mgm BD is  given  • Long acting drugs like Pyridostigmin ,may  be given  12/19/2016 66Prof.Dr.R.R.Deshpande
  • 67. Myasthenia Gravis – Treatment • Very large doses of Prostigmin may cause  ‘Cholinergic crisis’ • The symptoms are sweating, pallor,  fasciculations, small pupil ,salivation  • In this condition Inj Atropine must be  given immediately  12/19/2016 67Prof.Dr.R.R.Deshpande
  • 69. Myasthenia Gravis – Treatment • In respiratory distress ,Artificial Respiration  should be given  • Surgical Thymectomy ,can give permanent  cure ( specially in young females & when  disease is not more than 6 years duration  • In patients with Thymoma ,x ray radiation is given ,before operation 12/19/2016 69Prof.Dr.R.R.Deshpande
  • 70. Myasthenia Gravis – Treatment   • Thymectomy produces gradual improvement  in majority of cases • Thymus may contain modified muscle cells  with NRs on their surface, which may be the  source of the antigen for production of anti- NR antibodies in myasthenic patients. 12/19/2016 70Prof.Dr.R.R.Deshpande
  • 71. Myasthenia Gravis & Ayurved • This is Bala Kshaya ( Loss of strength) + • Glani + • Dhatu Kshatajanya Vata Prakop in Mansa  Dhatu  • Cause – Auto Immune Disease  12/19/2016 71Prof.Dr.R.R.Deshpande
  • 72. Myasthenia Gravis & Ayurved • Important Clinical features – • Abnormal fatigue & initially weakness of selected muscles i.e Eye, mouth, throat • Facial expressions are affected  12/19/2016 72Prof.Dr.R.R.Deshpande
  • 73. Myasthenia Gravis & Ayurved • Muscle weakness worsens  with activity  & improves with rest  • Ptosis, Double vision ,Dysarthria, Dysphagia • Muscles temporarily paralysed  • Breathing becomes difficult ,due to  weakness of chest wall muscles  12/19/2016 73Prof.Dr.R.R.Deshpande
  • 74. Myasthenia Gravis & Ayurved • Investigations –  • Ach receptor antibody in blood  • Edrophonium test – IV Endrophonium chloride or  Tensilon is given .This blocks degradation of Ach &  temporarily increase the level of Ach at the  neuromuscular junction  • In the patient who have involved the eye muscles  Endrophonium chloride will partially relieve  weakness  12/19/2016 74Prof.Dr.R.R.Deshpande
  • 75. Myasthenia Gravis & Ayurved • Nerve conduction study is done • CT scan can be used to detect abnormal  Thymus gland or the presence of  Thymone  12/19/2016 75Prof.Dr.R.R.Deshpande
  • 76. Myasthenia Gravis – Ayurved Treatment • Avaranaghna chikitsa • Dhatu Kshayajanya vata prakop chikitsa • Mansa Kshaya chikitsa • Bruhan ,Shramahar chikitsa • Ushna chikitsa 12/19/2016 76Prof.Dr.R.R.Deshpande
  • 77. Myasthenia Gravis & Ayurved • Tab Bruhatvat chitamani – 1 in morning with 2 tsf Chavanprash • Tab Bala Ghana vati 3 TDS with Ashwagandharishta 4 tsf with equal quantity of water • Kshirbala tail 10 ml + Prasaranyadi Tail 10  ml – with warm milk at night  12/19/2016 77Prof.Dr.R.R.Deshpande
  • 78. Myasthenia Gravis & Ayurved • External –  • Abhyana – Dhanvantaram Kuzambu or  Maha masha oil in the morning +  Alternate day Abhyanga with Sahachar  oil  • Basti – Mustadi Rajyapan Basti  • Nasya – Sahacharadi oil  12/19/2016 78Prof.Dr.R.R.Deshpande
  • 79. Almond oil for Myasthenia Gravis 12/19/2016 79Prof.Dr.R.R.Deshpande
  • 80. Rajyapan Basti-Indications • It is recommended in dry allergic cough or in • COPDs like emphysema, bronchiectasis, • chronic fever, gouty arthritis, irritable bowel • syndrome, Knee joint osteoarthritis etc. • It is used in Auto immune conditions like • Ankylosing spondylosis & RA. • Rajyapan Basti increases the strength, it • increases the sexual drive, improves the • digestion and Vital sap. 12/19/2016 80Prof.Dr.R.R.Deshpande
  • 81. Rajyapan Basti-Ingrediants • • Decoction of Ashwagandha, Shatavari, • Erandamool, Bala in a dose of 240 ml. • Honey - 20 ml. • Rock salt - 5 Gm • Sesame oil - 40 ml • Ghee - 40 ml. • Meat soup – 160 ml & Cow Milk – 160 ml. 12/19/2016 81Prof.Dr.R.R.Deshpande
  • 82. Myasthenia Gravis & Ayurved • Eat – Milk , Almond, Garlic • Avoid – Vata vruddhi kar Diet & Life style  •              Excess dry & cold food  • Avoid -- Hectic Life style 12/19/2016 82Prof.Dr.R.R.Deshpande
  • 83. Prof.Dr.R.R.Deshpande • Sharing of Knowledge  • FOR  • Propagating Ayurved 12/19/2016 83Prof.Dr.R.R.Deshpande