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ePAD project

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Professor Anthony J. Brookes (University of Leicester) on the ePAD project (

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ePAD project

  1. 1. EU Project Informatics Alignment Workshop EPAD: European Prevention of Alzheimer’s Dementia Anthony Brookes (University of Leicester) Imperial College London, UK April 28th-29th 2015
  2. 2. What is EPAD • Brief description of project objectives: – Deliver a standing, double-blind, Alzheimer’s disease proof-of-concept adaptive trial, sustainable beyond the project – Build on existing cohort, trial, analytical & informatics work (Aetionomy, EMIF-AD) – Thereby... a. Improve the chance of successfully preventing Alzheimer’s dementia b. Better understand early aspects of AD before dementia develops – In practice… Engage ~30 study sites ('Parent Cohorts') to establish 24,000 participants ('EPAD Register') and undertake longitudinal follow-up on 6,000 ('EPAD Cohort'), of which 1, 500 will be invited into trials to test new treatments for prevention of dementia. Ongoing feedback with modelling groups. • Funded by: IMI & EFPIA - initial combined budget of €64M • Time frames: 5 years (Jan2015 --- Dec 2019) • Members: – Pharma partners (13) Academic groups (16) Non profit organization(1) Commercial Suppliers (5)
  3. 3. Fingerprint Browser (cohort discovery) - questionnaire answers - browsing interface - identifies suitable PCs by their features Café Variome (subject discovery) - subject data, retained locally/safe - federated, real-time query portal - returns summary counts and IDs - options for controlled data sharing Modelling (in context of adaptive trial) - CROs to manage databasing - ‘generous’ data sharing
  4. 4. Data types collected by EPAD Data Type Standards Platform Date availability Restricted access TranSMART support Free text and semi-structured questionaire data No EMIF Browser Open No ??s Diverse but shallow existing phenotype data No Cafe Variome Intra-project discovery N/A ?? Diverse, extensive phenotype data Partly Cafe Variome and EMIF browser hybrid Controlled discovery and sharing Yes ?? Longitudinal phenotype data Yes Controlled Yes ?? Clinical trial data Yes Controlled Yes ??

Professor Anthony J. Brookes (University of Leicester) on the ePAD project (


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