DSPy a system for AI to Write Prompts and Do Fine Tuning
Articular cartilage
1.
2. Type of hyaline cartilage covers the bone
ends and makes smooth movements possible.
It distributes the load across
joints,minimizing the peak stress on
subchondral bone.
3. Relatively acellular.
No vascular,neural or lymphatic supply
Has little capacity to heal after injury.
Wear resistant
Low frictional
Lubricated surface
Slightly compressible and elastic
4. Differs from hyaline cartilage in that it is
not covered by perichondrium.
Collagen fibres of articular cartilage matrix
are of type-II which exhibit characteristic
cross banding of collagen fibres exsist.
5. Young cartilage – typically white,smooth,
glistening and compressible
Aged – thinner,less cellular,firmer and more
brittle with less regular surface and
yellowish opacity.
Thickness –
Bony end plate
6. ZONES OF ARTICULAR CARTILAGE
1) SUPERFICIAL ZONE
Not smooth,layer of hyaluronic acid
LAMINAR SPLENDENS –most superficial
Elongated chondrocytes,relatively inactive
2) TRANSITIONAL ZONE
Thicker ,cells rounded & larger, arranged pairs
Actively engaged in matrix component
synthesis
7. DEEP ZONE
- Largest zone
- Largest collagen fibrils,highest
proteoglycan content, lowest water
ZONE OF CALCIFIED CARTILAGE
- Irregular cells pyknotic nuclei /stability
- TIDE MARK
- Continuous with subchondral plate
8. PERICELLULAR MATRIX
- CHONDRON
- Modulate the pressure transmission
- regulation of chondrocyte response to
pressure,prevent squashing
TERRITORIAL MATRIX
- Fibrillar basket
- surrounds the pericellular matrix
9. INTERTERRITORIAL MATRIX
- Largest matrix compartment
- parellel arrangement of collagen fibrils
- responsible for mechanical properties.
10. Less than 1% of tissue volume
Rarely divide normally / cell density
decreases with age
Synthesize matrix components-
proteoglycans constantly renewed,collagen
slow turnover
CILIUM – Regulation of matrix turnover
11. COLLAGEN
- Type II ,major (90%)
- Characteristic cross banded fibrils
- Type IX,X,XI minor
NON-COLLAGENOUS PROTEINS
- Link protein /binding GAG to hyaluronic acid
- Chondronectin and anchorinCII
12. PROTEOGLYCANS
- Family of glycoproteins large protein core
attached to GAG side chains.
- Form of large aggregates
- Provide the resilience to A.C under load
13. Mature A.C – diffusion from synovial fluid
Immature A.C – vascular channels in sub
chondral bone,base of cartilage,S.F
Energy – anerobic pathway
Microenviroment:high CO2 & low O2
Survive for more than 2 days after death
14. CHONDROMALACIA:
A.C damage or degeneration
OUTER BRIDGE Classification:
Based on arthroscopic exam
15. GRADE O- Normal
GRADE I- Swelling & softening of intact A.C
GRADE II-Fissuring & fibrillation over small
area < .5 inch
GRADE III- Same over larger area > .5 inch
GRADE IV- Erosion of subchondral bone
16. Mitosis induced by laceration,compression,
Superficial lacerations – doesn’t cross tidemark donot
heal.
Penetrates the subchondral bone- reach
S.C vessels initiate healing process
Fibrinous arcade – scaffold that directs the
mesenchymal cells to form F.C matrix
Repaired tissue – intermediate between H.C
& F.C / poor biomehanical properties.
17. Biphasic material – solid & liquid phase
Fibre reinforced gel- mutually repellant
macromolecules binds water-osmotic P.
Water resides in microscopic pores and flow
of the water induced by pressure gradient
or matrix contraction.Flow pressure
provides load support & minimize stress
on matrix.
18. JT loading & motion required to maintain
normal adult A.C
Immobilisation of JT cause rapid loss of
proteoglycans so deformation in response
to load will increase.
Excessive use or increased loading affect
19. Debridement of chondral flaps and removal
of loose chondral fragments.
Abrasion chondroplasty
Microfracture