hormones

1. Hormone mechanism of action
M.Prasad Naidu
MSc Medical Biochemistry,
Ph.D.Research Scholar

3. Classification based on mechanism
of action
• Group 1 : bind to intracellular receptors.
eg; Androgens ,
calcitriol,
estrogens ,
glucocorticoids
progestrins
thyroid hormones

5. • Group II: Bind to cell surface receptors .
A. Second messenger cAMP
ACTH, ADH, hCG, CRH,FSH, LH,
PTH.
B. cGMP as second messenger.
ANF (atrial natriuretic factor)
Nitric oxide (NO).

11. • C. Calcium / phosphatidyl inositols as
second messenger
GnRH, TRH, PDGF, Substance P.
• D. Second messenger is a Kinase
/phosphatase cascade
Insulin, GH, prolactin , insulin like
growth factors(IGF-1,IGF-2).