NUCLEAR MAGNETIC RESONANCE
Presented by: Under the guidence of:
M.Pharm Mr. Paramdeep Bagga
Nuclear magnetic resonance spectroscopy(NMR) is a powerful
analytical technique used to characterize organic molecules by
identifying carbon-hydrogen frameworks within molecules.
It is a research technique that exploits the magnetic properties
of certain atomic nuclei.
It determines the physical and chemical properties of atoms or
the molecules in which they are contained.
Types of NMR
• Two common types of NMR spectroscopy are used to
characterize organic structure:
– 1H NMR:- Used to determine the type and number of H
atoms in a molecule
– 13C NMR:- Used to determine the type of carbon atoms in
• The theory behind NMR comes from the spin of
a nucleus and it generates a magnetic field.
• Without an external applied magnetic field, the
nuclear spins are random in directions.
• But when an external magnetic field (BO) is
present, the nuclei align themselves either with
or against the field of the external magnet.
Principles of NMR
If an external magnetic field is applied, an energy
transfer (∆E) is possible between ground state to excited
When the spin returns to its ground state level, the
absorbed radiofrequency energy is emitted at the same
The emitted radiofrequency signal gives the NMR
spectrum of the concerned nucleus.
It is use to identification of structrul isomertism
eg. n-propanol ,isopropanol
Identification of H bonding
Use for determination of aromaticities of compound
NMR technique use to distinguish betweeen cis and trans
Detection of Electronegative atom
Detection of some double bond character due to resonance
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