10. 抗体応答パターン
検査の選択
抗EA >= 1:640, 抗VCA IgG >= 1:5120といったHigh Titerがあり,
EBNA(-)ならばChronic Active Infectionを疑う
Ann Intern Med 1993;118:45-58
clovir group, but with no difference between the
two groups in the peripheral-blood EBV load.39
Larger randomized, blinded, placebo-controlled
trials are necessary to verify these results.
A recent report described reduced frequencies
of EBV-infected memory B lymphocytes in the pe-
ripheral blood of persons with chronic EBV infec-
tion who received valacyclovir therapy for 1 year,
as compared with untreated controls.40 EBV epi-
somal replication occurs through homeostatic
proliferation of memory B lymphocytes; this epi-
Figure 2. Levels of Antibodies Specific to Epstein–Barr Virus (EBV)
during Infectious Mononucleosis and Convalescence.
EBNA denotes EBV nuclear antigen, and VCA viral capsid antigens.
対象疾患 抗VCA抗VCA抗VCA EBNA 抗EA抗EA 異染性
抗体IgMIgM IgG IgA
EBNA
Diffuse Restricted
異染性
抗体IgM
伝染性単核球症 + ++ ± − + − +
回復期 − + − + − ± ±
感染の既往 − + − + − − −
Chronic Active Infection − +++ ± ± + ++ −
移植後リンパ増殖性疾患 − ++ ± ± + + −
Burkitt Lymphoma − +++ − + ± ++ −
鼻咽頭癌 − +++ + + ++ ± −