Evan Curtin from the Bradley Research Group at Drexel University presented a poster at the Research Day for the College of Arts and Sciences on April 5, 2011. The project involves the synthesis of aromatic imines and the measurement of their solubility to select an optimal solvent for their formation.
9. Online web service created by Professor Bradley (Drexel, Philadelphia, Pennsylvania) and Professor Andrew Lang (Oral Roberts University, Tulsa, Oklahoma)
21. During synthesis, benzalaniline was recrystallized in methanol. In order to extract the product, the mixture had to be cooled to precipitate in ethanol. The more substituted imine didn’t have to be cooled to form precipitate
22.
23. When solubility for a solute in 5 different solvents is found, this information can be used to predict solubility in 72 solvents using the Abraham model
27. MP of 227-230°C is consistent with impure 4-chlorobenzoic acidBoth of these reactions formed some of the desired imine, but after a cold ethanol wash, there was very little imine remaining Bradley, Jean-Claude and Lang, Andrew. “Open Notebook Science Web Services.” <http://onswebservices.wikispaces.com/> Curtin, Evan. “Synthesis of four imines from vanillin, p-chlorobenzaldehyde, aniline and o-chloroaniline.” <http://usefulchem.wikispaces.com/Exp262> Curtin, Evan “Synthesis of an imine from benzaldehyde and aniline.” <http://usefulchem.wikispaces.com/Exp261> Curtin, Evan. “Determination of solubility of sample 1A from UCExp262.” <http://onschallenge.wikispaces.com/Exp206> Curtin, Evan. “Determination of solubility of sample 1A from UCExp262 in toluene, acetonitrile, THF, and chloroform.” <http://onschallenge.wikispaces.com/Exp207> Gut, Jiri. “Falcipain-2 inhibition results for 2 Ugi products.” < http://usefulchem.wikispaces.com/Exp165> “Malaria Fact Sheet.” World Heath Organization. 2004. <http://www.who.int/mediacentre/factsheets/fs094/en/index.html> <http://onswebservices.wikispaces.com/> Mirza, Khalid Baig. “Synthesis of compounds ranked 55-124 from library DEXP014-V2B” <http://usefulchem.wikispaces.com/Exp181> “Priority Environment and Health Risks.” World Health Organization. 2004. <http://www.who.int/heli/risks/en/> (Ref: “Synthesis of an imine from benzaldehyde and aniline.” “Synthesis of four imines from vanillin, p-chlorobenzaldehyde, aniline and o-chloroaniline.”) (Ref: “Synthesis of four imines from vanillin, p-chlorobenzaldehyde, aniline and o-chloroaniline.”)