This PPT covers leukocytosis and includes Types of leukocytosis-Neutrophilia, eosinophilia, basophilia, lymphocytosis and monocytosis, pathophysiology of leukocytosis, symptoms of leukocytosis and diagnosis of leukocytosis
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Pathophysiology of leukocytosis
2. LEUKOCYTOSIS
Leukocytosis is white cells (the leukocyte count) above the normal range in the
blood.
It is frequently a sign of an inflammatory response most commonly the result of
infection, but may also occur following certain parasitic infections or bone
tumors.
It may also occur after strenuous exercise, convulsions such as epilepsy, emotional
stress, pregnancy and labour, anesthesia
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3. TYPES OF LEUKOCYTOSIS
There are five principal types of leukocytosis:
Neutrophilia (the most common form)
Eosinophilia
Basophilia
Lymphocytosis
Monocytosis
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4. This increase in leukocyte (primarily neutrophils) is usually accompanied by a
"left shift" in the ratio of immature to mature neutrophils.
The proportion of immature leukocytes increases due to proliferation and release
of granulocyte and monocyte precursors in the bone marrow which is stimulated
by several products of inflammation
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8. Monocytosis
Cause of Monocytosis are
Chronic infections
Tuberculosis
Bacterial endocarditis
Malaria
Inflammatory bowel diseases, e.g. ulcerative colitis
Systemic autoimmune diseases
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9. Lymphocytosis
Cause of Lymphocytosis are
Chronic infections
Tuberculosis
Brucellosis
Viral infections
Hepatitis
Cytomegalovirus infection
Pertussis
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10. SYMPTOMS
The following are common symptoms:
Fever.
Bleeding or bruising.
Feeling weak, tired, or sick.
Feeling dizzy, faint, or sweaty.
Pain or tingling in your arms, legs, or abdomen.
Trouble breathing, thinking, or seeing.
Losing weight without trying, or a poor appetite.
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