Vaccination progam in farm animals prof. dr Alaa Basyoni prof hamed attia

1. Prof. DrProf. Dr AlaaaAlaaa BasionyBasiony
ProfProf. Dr. Dr hamedhamed AttiaAttia
Department of animal medicineDepartment of animal medicine
Faculty of veterinary medicineFaculty of veterinary medicine
Zagazig universityZagazig university
VACCINATION PROGRAM
IN FARM ANIMAL

2. *VACCINATION PROGRAM IN
FARM ANIMAL
*TYPES OF VACCINE USED
*CAUSES OF VACCINE FAULER

3. INFECTIOUS VACCINESINFECTIOUS VACCINES
(ANTIGENS)(ANTIGENS)
 TYPES:TYPES:
–– 11--modified live vaccinesmodified live vaccines
intramuscular,intramuscular, subcutaneous,subcutaneous,
intranasalintranasal

4. IMMUNITY DURATIONIMMUNITY DURATION
–– lifelife--time (infection established,time (infection established,
cellular andcellular and humoralhumoral immunity)immunity)
–– one dose requiredone dose required
–– annual boosters may not be requiredannual boosters may not be required

5. 22--NONNON--INFECTIOUS VACCINESINFECTIOUS VACCINES
(ANTIGENS)(ANTIGENS)
 TYPES:TYPES:
–– killed vaccines and bacterinskilled vaccines and bacterins ––
intramuscular, subcutaneousintramuscular, subcutaneous
–– toxoids and leukotoxoidstoxoids and leukotoxoids ––
intramuscular, subcutaneousintramuscular, subcutaneous

6.  IMMUNITY DURATION:IMMUNITY DURATION:
–– 44 toto 1212 months (infection notmonths (infection not
established,established, humoralhumoral immunity)immunity)
–– primary dose required (priming)primary dose required (priming)
–– secondary dose requiredsecondary dose required –– 33 toto 66 weeksweeks
later (withinlater (within 44 months)months)
–– Annual or semiannual boosters requiredAnnual or semiannual boosters required

7. VACCINE INSTRUCTIONSVACCINE INSTRUCTIONS
 FOLLOW THE LABEL:FOLLOW THE LABEL:
 refrigerate in use and storagerefrigerate in use and storage
 use sanitary practices in useuse sanitary practices in use
 keep out of sunlight in usekeep out of sunlight in use
 properly dispose of opened vialsproperly dispose of opened vials
after useafter use
 Notice expiration date of unopenedNotice expiration date of unopened
vialsvials

8. VACCINE LABEL USE DIRECTIONSVACCINE LABEL USE DIRECTIONS
 FOLLOW THE LABEL:FOLLOW THE LABEL:
–– dosedose
–– route(s)route(s)
–– withdrawal time for slaughter (withdrawal time for slaughter (2121 toto
6060 days)days)

9. VACCINE FAILURESVACCINE FAILURES
 NO RESPONSENO RESPONSE ::
 EfficacyEfficacy
 stressstress
 malnutritionmalnutrition
 IMPROPER DOSE:IMPROPER DOSE:
 IMPROPER ROUTE:IMPROPER ROUTE:

10.  MISHANDLEDMISHANDLED ::
 nonnon--refrigeratedrefrigerated
 Sunlight exposureSunlight exposure
 UnsanitaryUnsanitary
 STORED OPENED VIALSSTORED OPENED VIALS
 EXPIRED VACCINEEXPIRED VACCINE
 POOR QUALITY VACCINEPOOR QUALITY VACCINE

11. Bacterial
vaccines
Viral
vaccines
8. Covexin* 8
9. Ultrabac® 8
4. Sheep pox
vaccine
Mixed
vaccines
1. FMD vaccines
3. BEF Vaccine
5. PNEUMO 3
6. PNEUMO 4
2. RP Vaccine
1. BCG vaccine
2. HS Vaccines
3. Pneumo - Bac
4. Brucella Abortus
Strain 19 Vaccine
7. Brucella Melitensis
Vaccine Strain “REV. 1”
1. Entero – 3
Vaccine
7. CattleMaster4
8. Vira Shield 5
2. ScourGuard 3
6. Abortex
5. RB51 vaccine

12. 1-Viral Vaccine

13. 1-MD Vaccine

14. Monovalent Inactivated FMD Vaccine
(type O1/93 locally isolated in Egypt)
Protection of cattle, buffaloes,
sheep and goats against FMD
First dose:
- Cattle & buffaloes 3 months & older 2 ml
- Sheep & goats 1 ml
- Dairy cattle revaccinated every 4 months .
- Breeding calves sheep & goats revaccinated every 4-6 months.
PACKAGE:
Each bottle Contains 300 ml
Second dose:
4 wks post 1st dose.
SC
1-

15. Bivalent Inactivated FMD Vaccine
(type O1/93 and type AEGY/06
locally isolated in Egypt)
Protection of cattle, buffaloes,
sheep and goats against FMD
First dose:
- Cattle & buffaloes 3 months & older 2 ml
- Sheep & goats 1 ml
- Dairy cattle revaccinated every 4 months .
- Breeding calves sheep & goats revaccinated every 4-6 months.
PACKAGE:
Each bottle Contains 300 ml
Second dose:
4 wks post 1st dose.
SC
1-

16. :
The vaccine contains virus of FMD type O (1/93)
and type A (EGY/06).
It is locally isolated in Egypt.
It is inactivated by 2- bromoethylamine
hydrobromide (BEI).
Adjuvanated by aluminum hydroxide gel and
purified saponin.
COMPOSITION

17. INTERACTIONS:
Other vaccination programs
should be carried out at least two
weeks before or after FMD
vaccination.

18. PROPAGATION SYSTEM:
Baby hamster kidney monolayer cell
line (BHK).
INSTRUCTIONS FOR USE:
Shake the bottle before use.
 the vaccine is inoculated subcutaneously in the dwelap
10-15 cm in front of the sternum.
 In sheep and goats subcutaneously behind the shoulder
or in the middle of the lower side of the neck.
 Press on the injection site for a while then make gentle
massage for a short time. The vaccine gives immunity for

19. VACCINE REACTION
A painful swelling may be developed
within one or two days at the site of
injection .
It does not influence the general
condition of the animals.
This swelling subsides within 10 days.
No drop in milk production.

20. Aftovaxpur
- 2 ml Cattle
- 1ml Sheep
- 6 m
Inactivated polyvalent vaccine
(O1, A22, SAT2, ASIA1)
Type:
Dose:
- SC
- 300 ml 3500 LE
Route:
Duration of immunity: Price:
3-

21. 2-Rinder Pest
Vaccine

22. Attenuated T.C. Vaccine
(" RBOK " strain)
PACKAGE:
Available in vial of 50 or 100 doses.
Protection of cattle & buffalo
against Rinderpest
1ml
SC
Solid immunity last for
5 – 6 years
Dissolve the lyophilized material in 50
or 100 ml sterile chilled physiological
saline solution. Use it within one hour

23. Cell culture Rinderpest vaccine is an attenuated vaccine which
confers immunity for many years when inoculated at optimum
conditions. Vaccine is prepared according to FAO and OIE
instructions , by using the international reference
" RBOK " strain .
MODE OF USE:
-Dissolve the lyophilized material in 50 or 100 ml (according to the
dose) sterile chilled physiological saline solution. Use it within one
hour. -The dose (1ml contain at least 103 TCID50 ) is injected
subcutaneously. -Inoculate each animal with (1 ml ) of dissolved
vaccine subcutaneously using sterile syringe. -Separate, sterile
syringe is necessary for each animal.-Vaccine should be kept on
ice, away from sunlight throughout the time of use. -Don’t use
disinfectant, alcohol to sterile needles.-The vaccine is completely
safe for Pregnant animals within the previously mentioned dose.

25. Inactivated Vaccine
Protective of cattle & buffalos
against BEF
2ml
PACKAGE:
Each bottle contains
20 ml (10 doses).
SC
- Second dose ( booster dose) :
2ml after 4 weeks.
- The same program repeated
annually.
Animals must be
vaccinated before
summer season

26. COMPOSION:
Each dose contains at least 106.5 TCID50 of the virus.
PROPAGATION SYSTEM:
Green monkey kidney cell line ( VERO ).
VACCINATION PROGRAME:
- Animals of 6 months age vaccinated with the vaccine.
- First dose : 2ml injected (S/C ).
- Second dose ( booster dose) : 2ml injected S/C after 4 weeks.
- The same program repeated annually.
Inactivated Bovine Ephemeral Fever Vaccine
REMARKES:
- The vaccine is safe for pregnant and lactating animals.
- Animals must be vaccinated before summer season.
CONTRAINDICATION:
Animals clinically ill or those weakened should not be vaccinated.

27. 4- Respiratory Virus Vaccine
IBR,
BVD,
PI- 3
& BRS
diseases

28. 4-Types of
Respiratory Virus Vaccines

29. 1-Egypian
Respiratory Virus Vaccines

30. Combined Inactivated
Respiratory Virus Vaccine
Cattle & buffalo 5 ml
Sheep 3 ml
PACKAGE:
bottle 100 ml (20 doses).
Protection of cattle,
buffaloe & sheep against
IBR, BVD, & PI- 3 diseases
IM
6 m
2nd dose 2 weeks apart
1

31. DESCRIPTION:
A combined inactivated vaccine used for protection of cattle,
buffaloe and sheep against IBR, BVD, & PI- 3 diseases.
"PNEUMO 3"
COMPOSITION:
- Each dose contains not less than:
- IBR 106 TCID50
- BVD 106 TCID50
- PI – 3 106 TCID50
- Adjuvants : aluminum hydroxid gel.
VACCINATION PROGRAMME:
- Animals vaccinated at ( 2 – 4 ) months old, 2nd dose must be given two
weeks after the 1 st dose . Then revaccination should be done every 6
months.
- Pregnant cow dames could be vaccinated with two doses, two months
before parturition with 2 weeks interval.
- Animals from non vaccinated dames could be vaccinated at age of 3-4
weeks.

32. PACKAGE:
bottle of 100 ml (20 doses).
Combined Inactivated
Respiratory Virus Vaccine
Cattle & buffalo 5 ml
Sheep 3 ml
Protection of cattle, buffaloe
& sheep against IBR, BVD,
PI- 3 & BRS diseases
IM
6 m
2nd dose 2 weeks apart
2

33. " Pneumo 4"
DESCRIPTION:
A combined inactivated vaccine used for protection of cattle, Buffalo
and sheep against IBR, BVD, PI- 3 & BRS diseases.
COMPOSITION:
Each dose contains not less than:
IBR 106 TCID50
BVD 106 TCID50
PI – 3 106 TCID50
BRS 106 TCID50
Adjuvants : aluminum hydroxid gel.
VACCINATION PROGRAMME:
- Animals vaccinated at 2 – 4 months old, 2nd dose must be given two
weeks after the 1 st dose . Then revaccination should
be done every 6 months.
- Pregnant dams could be vaccinated with two doses, two months
before parturition with 2 weeks interval.
- Animals from non vaccinated dames could be vaccinated at age of 3- 4
weeks.

34. 2-Forien
Respiratory Virus Vaccines

35. Indications:
For vaccination of healthy cattle,
including pregnant cows, as an aid in
preventing abortion caused by
infectious bovine rhinotracheitis (IBR,
bovine herpesvirus Type 1),
persistently infected calves caused by
bovine viral diarrhea (BVD) virus Types
1 and 2, respiratory disease caused by
IBR, BVD (Types 1 and 2),
parainfluenza3 (PI3 ) and bovine
respiratory syncytial virus (BRSV) and
leptospirosis caused by Leptospira
canicola, L. grippotyphosa, L. hardjo,
L. icterohaemorrhagiae and L. pomona.
CattleMaster® GOLD™ FP® 5
L5
1

36. Protection of cattle &
buffaloe against IBR,
BVD, PI- 3 & BRS
diseases
IM
2 ml
Combined vaccine
2nd dose 2 weeks apart
One year

38. Dosage and Administration
General Directions: Vaccination of healthy cattle is
recommended. Aseptically rehydrate the freeze-dried
vaccine with the liquid component provided, shake well
and administer 5 mL subcutaneously. In accordance with
Beef Quality Assurance guidelines, products should be
administered in the muscular region of the neck.
Primary Vaccination: Administer an initial 5-mL dose,
followed by a second 5-mL dose 3 weeks later. As an aid in
preventing IBR-induced abortion and BVD persistently
infected calves, administer at approximately 5 and 2 weeks
prior to breeding. Calves vaccinated before the age of 6
months should be revaccinated after 6 months of age.
Revaccination: Annual revaccination with a single dose is
recommended.
Good animal husbandry and herd health management
practices should be employed.

40. Protection of cattle
& buffaloe against
IBR, BVD (2 types)
, PI- 3 & BRS
diseases
IM or SC
5 ml
Combined
Inactivated
Vaccine
2nd dose 4 weeks apart
One year
2

42. 5-Sheep Pox Vaccine

43. Protects sheep & goats against
pox disease, & cattle against LSD
I/D or S/C
0.5 ml
Live attenuated freeze dried
tissue culture vaccine
one year
PACKAGE:
Each vial contains 100 dose.

44. Tissue Culture Sheep Pox Vaccine
COMPOSITION:
Each dose contains at least 102.5 TCID50.
PROPAGATION SYSTEM:
Green Monkey Kidney cell line ( Vero ).
DOSAGE:
- Reconstitute the vial contents in 50 ml physiological saline.
- Each dose is 0.5 ml injected interadermally (I/D) or subcutanously (S/C).
- Vaccination repeated annually.
REMARKS:
- The reconstituted vaccine should be used within two hours.

45. 2-Bacterial Vaccine

46. 1-BCG Vaccine

47. Strain called bacille Calmette &
Guerin
Developed by Albert Calmette &
Camille Guerin two french
investigors in 1920s
attenuated strain of M. bovis
0.5 cm for cow & buffalo male calves
0.1 cm for lambs
Intradermal
Once / life (solid immunity)
Freeze Dried B.C.G. Vaccine

48. the BCG was not an effective cattle vaccine
1. Used to protection of human and animals against tuberculosis
2. Give non-specific immunity to another diseases by
stimulation the immune system as:
a) Caseous lymphadenitis. b) Brucellosis.
c) Haemorrhagic septicemia. d) Listeria.
d) Staph. aureus. e) Strept. pyogens.
f) Salmonellosis. g) Pox
h) Rift Valley Fever
3. When used in fed lot animals increase the food conversion rate
Used in males onlydue to vaccinated animals persist to give tuberculin
test positive (false +ve) so, it interfere with test and slaughter program.

49. BCG Vaccine.
COMPOSITION :
* Vial containing 5 mg of lyophilized vaccine.
* Vial containing 6 ml of diluent ( Sauton 1+ 3 )
INDICATIONS :
1) Provide non specific immunity against viral, bacterial and parasitic diseases.
2) Protect sheep from Pseudo tuberculosis, Pox and Rift Valley Fever.
3) Increase the immune efficacy and body weight gain of fattening calves.
DIRECTIONS AND DOSAGE:
The lyophilized vaccine is reconstituted with the diluent and injected I/D as follows
: AnimalDilution Dose Vacc. Conc. Site Cow - calves2.5 ml 0.5 ml1 mgUnder the tail. Buffaloe -
calf 2.5 ml0.5 ml1 mgSide of the neck Sheep 5 ml0.1 ml0.1 mgInner aspect of the thigh or under
the fatty tail.Lambs10 ml0.1 ml0.05 ml
PRECAUTIONS:
1) The vaccine should be used quickly as possible after reconstitution, and any remaining vaccine
should be discarded.
Un used diluted vaccine, empty vails and used syringes must be disposed hygienically. 2) Bulls,
cows and buffaloes never to be vaccinated .
3) Vaccination is stopped in cases of general weakness, serious skin diseases and acute illness (
fever )
STORAGE:
The vaccine should be stored in a dry place protected from direct sunlight or diffuse day light at a
temperature between 4 - 8oC, not freezer.
Validity :
Tow years from the manufacture date.
PACKAGE:
A vial containing 5 doses for calves or 50 doses for sheep.

50. 2- Pasteurellosis Vaccine

51. Inactivated HS Oil Adjuvant
Vaccine (type B:6)
PACKAGE:
bottle 300 ml. (150 dose).
Protection of cattle & sheep
against HS & pneumonic
pasteurellosis
2 ml in cattle
1 ml in sheep
IM
9 m
1

52. DESCRIPTION:
Haemorrhagic septicaemia oil adjuvant is an inactivated oil emulsion
vaccine used for active immunization of cattle against haemorrhagic
septicaemia and pneumonic pasteurellosis.
COMPOSITION:
Each dose of the vaccine contains pasteurella multocida type B:6
inactivated with formalin and emulsified in oil base.
VACCINATION PROGRAM:
- In areas where the disease occur seasonaly animals should be vaccinated
two or three weeks before the season.
- Where the incidance is not seasonal, animals should be vaccinated every
nine months.
- When outbreaks of the disease occur, all contact stock must be
vaccinated as soon as possible.
RECOMENDATIONS:
- Shake the vaccine vigoursly before and during use to ensure good mixing.
- Allow the vaccine to reach room temperature before vaccination.
- Intravenous injection must be avoided.
- Animals to be vaccinated should be in good health and not suffering from any disease.

53. Inactivated Oil Adjuvant
Polyvalent Pneumonic
Pasteurellosis Vaccine
Cattle and buffaloes:
Over 100kg 2ml
Under 100kg 1ml.
Sheep & goat : 1ml.
PACKAGE: bottles 300 ml. (150 dose for cattle, 300 dose for sheep & goat).
Protection of Cattle, Sheep & Goat
against pneumonic pasteurellosis.
2nd dose 4 weeks apart
One year
IM
2

54. Protects against H.S. in
horses, mules & donkeys
S/C
1 ml at 6th month
2 ml at 1 year
3 ml at 2 years
5 ml at 3 years
Formalized killed vaccine
6 months
3

55. DESCRIPTION:
Pneumo - bac is an inactivated oil adjuvant polyvalent pasteurellosis
vaccine used for active immunization of cattle, sheep and goat against
pneumonic pasteurellosis.
COMPOSITION:
The vaccine contains pasteurella multocida types A,B & D and pasteurella
haemolytica types A & T inactivated with formalin and emulsified in oil
base.
VACCINATION PROGRAM:
- Animals vaccinated with two doses four weeks internal.
- For pregnant animals, vaccination with two doses four weeks internals at
6-8 weeks before parturition.
- Animals born from vaccinated dams should be vaccinated at 8 weeks of
age.
- Animals born from unvaccinated dams should be vaccinated at one week
age.
- Revaccination with one dose annually.
RECOMENDATIONS:
- In areas where the disease occurs seasonally, animals should be vaccinated
at 4 or 5 weeks before the season.
- When outbreaks of the disease occur, all contact stock must be vaccinated as
soon as possible.

56. 3-Brucella Vaccine

57. PACKAGE:
Vials 10 ml contains 10 reduced doses of lyophilized vaccine
( 3-10 x 109 CFU / dose ( accompanied with 20 ml diluent.
Protection of cattle, buffaloes
against Brucellosis
Living attenuated smooth B.abortus strain 19 in
serous form or freeze dried (lyophilized vaccine).
SC to female calves between 4 to 8 months old
5 successive years
Full dose (standard dose): about 60 – 80 x109
microbial cells in about 2ml.
Reduced dose (1/20 of full dose): It is widely used
nowadays specially in un-affected herd and it is
characterized by rapid decline in aglutinins.
1

58. * Used in female calves at 4 – 8 months (average 6
months).
* Not used before 4 months of age due to:
(1) Reticulo-endothelial system is still undeveloped
so may result in low titer of antibodies (not
protect against disease).
(2) When given at this age, the colostrums
antibodies interfere the microbial dose and so
the immunity produce is low.
* Not used after 8 months of age: Animal produces
permanent agglutinin titer (permanent +ve
serological test).

59. * Disadvantage of this vaccine:
(1) Used to vaccination of female only due to it
produce orchitis in bull.
(2) Not use in adult female as it cause abortion
except it can use in adult female in case of
outbreak.
(3) Interfere with control program due to it give
serological +ve (5% of vaccinated animal give
resistant agglutinin for 2 – 3 years).
(4) Give infection and un-dutant fever to human.
(5) Not prevent complete infection from udder.
(6) It need to be refrigerated, problems of storage
and transport at 4oC.

60. COMPOSITION:
Each dose of reconstituted vaccine contains 3-10 x109
CFU of Brucella abortus Strain 19.
ADVERSE REACTIONS:
These occur rarely in both calves and adults , to be more
sever in foreign breeds.
A local swelling occurs particularly in adult cattle and
there may be a sever systemic reaction manifested by
fever lasting
for 2-3 days.
Anaphylactic shock may occur and immediate treatment
with adrenaline hydrochloride ( 1m1. of 1 : 1000 diluted
solution
injected subcutaneously ) or Antihistaminic drug, is also
recommended

61. Live attenuated vaccine of Brucella
abortus rough strain RB51
10 – 34 million bacteria/2ml as one
or 2 dose 30 day interval
Protection cattle, buffaloes & sheep
against brucellosis by B. abortus.
1 – 2 years and animals
vaccinated annually
SC
2

62. 1. Not result in measurable Ab titers to B. abortus using
standard diagnostic tests so, not interference with
eradication program of Brucellosis using such test.
2. Eliminate costs associated with resting and trace backs
of false +ve reactors as in B. abortus st. 19 vaccine.
3. Not excrete in excretion and secretion of animals.
4. Used in all ages of the animals.
5. There is no any side effect on vaccinated animals.
6. Not protect animal infected with another species of
Brucella as Brucella melitensis
- Age: Female calves of 4 – 12 months.
- Adult non-pregnant female. (Cause abortion)
Advantages:

63. Brucella Melitensis Vaccine Strain “REV
PACKAGE:
- Vials 10 ml contains 10 doses of lyophilized vaccine (1 to 2 x 109
CFU / dose ( accompanied with 20 ml diluent.
- Vials 10 ml cantains 5 doses of lyophilized vaccine ( 1- 2 x 109
CFU / dose( accompanied with 10 ml diluent.
INDICATIONS AND DOSAGE:
After reconstitution with the accompanied diluent, it should contain 1
to 2 x 109 CFU viable organisms per 2 ml dose, given
subcutaneous to lambs and kids aged between 3 to 8 months.
Vaccination is followed by the appearance of specific antibodies.
Do not vaccinate pregnant or lactating females two month prior to
meeting.
Living attenuated B. Melitensis vaccine
3

64. COMPOSITION:
Each dose of reconstituted vaccine contains 1 to
2 x 109 CFU of Brucella Melitensis “Strain Rev.
1.”
ADVERSE REACTIONS:
These occur rarely in both young or adult.
A local swelling may occurs .
Severe systemic reaction manifested by fever lasting
for 2-3 days.
Allergic reaction may occur .
treatment with adrenaline or antihistaminic drugs
should be done.

65. 3-Clostridial Vaccine

66. clostridial diseasesclostridial diseases
Lamb dysentery
Struck
Pulpy kidney
Braxy & Malignant oedema
Blackleg
Tetanus
Black disease
Bacillary haemoglobin urea
Cl. perfringens type B
Cl. perfringens type C
Cl. perfringens type D
Cl. novyi type B
Cl. septicum
Cl. chauvoei
Cl. novyi type D
Cl. tetani
caused by

67. ULTRABAC® 7
• ULTRABAC 7 provides effective,
protection against the following key
clostridial diseases:
• blackleg – Cl. chauvoei
• malignant edema – Cl. septicum
• black disease – Cl. novyi
• gas-gangrene – Cl. sordellii
• enterotoxemia, enteritis – Cl. perfringens
types B, C, and D
Packaging:
10-, 50-, & 200-dose vials
Dosage & route:
Shake well. Aseptically administer 5 mL
subcutaneously, followed by a second
dose 4–6 weeks later
Annual revaccination with a single dose is recommended
Indications:
1

68. Protects cattle, sheep & goat
against 8 clostridial diseases
S/C
Polyvalent formalized
killed vaccine
6 months
2nd dose
2 ml
5 ml
6 W1st dose
2 ml
5 ml
sheep
cattle
2

69. Protects cattle, sheep & goat
against 8 clostridial diseases
S/C
Polyvalent formalized
killed vaccine
6 months
2nd dose
2 ml
5 ml
6 W1st dose
2 ml
5 ml
sheep
cattle
3 Cubolac 8
United Biofarm

70. Protects cattle, sheep & goat
against 8 clostridial diseases
S/C
Polyvalent formalized
killed vaccine
6 months
2nd dose
2 ml
5 ml
6 W1st dose
2 ml
5 ml
sheep
cattle
3-Covaccin 10
10

71. Protects sheep & goat against
8 clostridial diseases
S/C
1st dose
5 ml
Polyvalent formalized
killed vaccine
6 months
2nd dose
3 ml
6 W
4

72. 3-Mixed Vaccine

73. Inactivated Bovine Rota, Corona
Viruses and E-Coli Vaccine
Protection of newly born calves
against diarrhoea caused by
Rota, Corona viruses and E-Coli
4 ml in pregnant cow or buffalo
PACKAGE:
bottles of 20, 40 and 100ml.
IM
2 doses at least two weeks apart to
pregnant cows, the second dose
given 2-3 weeks before calving.
One year
1

74. COMPOSITION:
Each dose contains at least 106 TCID50 of each
bovine Rota and Corona viruses and 6x1010 CFU of E
- Coli k99 Pili.
VACCINATION PROGRAMME:
- Two I/M doses at least two weeks apart
to pregnant cows, the second dose given 2-
3 weeks before calving.
- Revaccination with a single third dose if
cows have not calved within 40 days after
receiving their last dose.

75. Inactivated Bovine Rota, Corona
Viruses and E-Coli Vaccine
Protection of newly born calves
against diarrhoea caused by
Rota, Corona viruses and E-Coli
IM
2 doses at least two weeks apart to
pregnant cows, the second dose
given 2-3 weeks before calving.
2 ml in pregnant cow or buffalo
One year
2

76. Inactivated Bovine Rota, Corona
Viruses and E-Coli Vaccine
Protection of newly born calves
against diarrhoea caused by
Rota, Corona viruses and E-Coli
IM
2 ml at 160 days old
One year
3 Rota-vec Vaccine

77. Vaccination programme
in
dairy farms

78. Vaccination programme
in
dairy farms

79. Cow Herd VaccinesCow Herd Vaccines
 Precalving Vaccination of Cows andPrecalving Vaccination of Cows and
HeifersHeifers
((77 toto 99 months of pregnancy or twice a year)months of pregnancy or twice a year)
1.1. 44--way Viral BRD Vaccineway Viral BRD Vaccine
2.2. Pasteurella Bacterin & LeukotoxoidPasteurella Bacterin & Leukotoxoid
3.3. Clostridia Bacterin & LeukotoxoidClostridia Bacterin & Leukotoxoid
4.4. Scour VaccineScour Vaccine

80. 11--Lumpy Skin DiseaseLumpy Skin Disease
vaccinevaccine
 First injection in FebruaryFirst injection in February
 The second dose every yearThe second dose every year

81. 22--FMD vaccineFMD vaccine
 First injection in AprileFirst injection in Aprile
 The second dose afterThe second dose after 22 weeksweeks
 The next vaccine everyThe next vaccine every 44 monthsmonths

82. 33--Rift valley vaccineRift valley vaccine
 First injection in AprilFirst injection in April
 The second dose in OctoberThe second dose in October

83. 44--Respiratory virusRespiratory virus
vaccinevaccine
 Calves are vaccinated atCalves are vaccinated at 6060 days @days @
180180 daysdays
 All animals are vaccinated annually inAll animals are vaccinated annually in
septemberseptember

84. 55--Viral and bacterial diseasesViral and bacterial diseases
causing diarrhea vaccinecausing diarrhea vaccine
(Rota , corona @ E coli)(Rota , corona @ E coli)
 All pregnant cows are vaccinated atAll pregnant cows are vaccinated at
255255 days of pregnancy.days of pregnancy.
 The second booster dose atThe second booster dose at 22 weeksweeks
before parturitionbefore parturition

85. 6-Brucellosis
vaccine (everyvaccine (every 33 years)years)
 First injection in JanuaryFirst injection in January
 The second dose everyThe second dose every 33 yearsyears

86. 77--Clostredial DiseaseClostredial Disease
vaccinevaccine
 First injection in calves atFirst injection in calves at 1414 andand 4242
days olddays old
 The second dose every yearThe second dose every year
 All pregnant cows are vaccinatedAll pregnant cows are vaccinated 22
weeks befor parturation .weeks befor parturation .

87. 8-pasteurellosis
vaccine (Annually)vaccine (Annually)
 All pregnant cows areAll pregnant cows are
vaccinated at every year (invaccinated at every year (in
April month)April month)