13. OncoTypeDX
for Estimating Recurrence Risk After Lumpectomy with No Radiation
Score Any Recurrence Invasive Recurrence
Low Risk 12% 5%
Intermediate Risk 25% 9%
High Risk 27% 19%
E5194 study
http://www.genomichealth.com/en-US/OncotypeDX.aspx
further validation of these results is required
44. • High tangent fields includes
most of area at risk
• Superior border: Just below
humeral head
• Posterior border: 2 cm
within the lung includes:
– over 95% of SLN
– over 80% of level I and II axilla
Schlembach, Int J Rad Oncol Biol Phys, 2001
62. • The breast should receive a dose of 45-50 Gy
in 1.8 – 2 Gy per fraction, 42.5 Gy at 2.66 Gy
per fraction.
• A boost to the tumor bed is recommended for
patients in higher risk for local failure:
– Age < 50
– Positive lymph nodes
– LVI
– Close margins
85. A lot of subgroups
No RT of breast in DCIS
No RT of breast in early stage of invasive ca
No boost
Hypofractionated RT of whole breast
Accelerated Partial RT