PHP presentation

1. Clinical Pathology Case
Presentation
Annie Thomson

2. History & Signalment
 9 year old female neutered Boxer
 History of lameness

3. Main Abnormalities Found
Haematology
 Normocytic
normochromic
anaemia
 Thrombocytopenia
 Leukopenia
 Neutropenia
 Rouleaux formation
Biochemistry
 Hyperproteinaemia
 Hypoalbuminaemia
 Hypercalcaemia
Urinalysis
 U.S.G 1.016
(isosthenuric)

4. Serum Protein
Electrophoresis

5. Information on SPEP
 Measures specific proteins in the blood
 Results can help differentiate between neoplastic
and non-neoplastic disease

• Normal
• Polyclonal gammopathy seen in
 Inflammation
 Immune-mediated disease
• Monoclonal gammopathy seen with
some neoplastic diseases
 Multiple myeloma
 B cell lymphoma
 Chronic lymphocytic leukaemia

6. Likely Differentials
 Multiple myeloma
Hyperproteinamia
Hypercalcaemia is a recognised paraneoplastic
syndrome
Myelophthisis  cytopenias
Monoclonal gammopathy
Skeletal lesions  lameness?
• Lymphoma