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analysis of
ChakshusHya DravyaS
PRESENTER
DR.SWATI.S.SUVARNA
FINAL YEAR PG SCHOLAR
G.A.M.C,BENGALURU
CONTENTS
 INTRODUCTION
 WHY ANALYSIS OF CHAKSHUSHYA DRAVYAS IS
NECESSARY??
 CHAKSHUSHYA VERSES RASAYANA.
 CHAKSHUSHYA DRAVYAS.
 MODE OF ACTION OF CHAKSHUSHYA DRAVYAS
 DISCUSSION.
 CONCLUSION.
INTRODUCTION
• Every Human wishes to have a long, happy
and healthy life.
• To fulfill this they tend to work hard which
makes them stressed, irregular and non-
nutritive food habits,irregular sleep
pattern which brings stress on mind and
eyes-all these reduces the longevity of
each individual..
• Apart, Newer organisms, Environmental
changes have also caused tremendous
reduction in the quality of life.
• Pertaining to eyes Cataract, ARMD,
Degenerative myopia,Early changes in eye
due to Diabetes,HTN etc.are major
challenging disorders.
• The present era is also witnessing new
disorders like corneal epithelial erosion
syndrome, Dry eye syndrome,smart phone
syndrome and along with changing pattern
of existing disorders.
• So to overcome from all these
disorders, chakshushya dravyas and
chakshu kamya rasayanas are
helpful.
chakshushya??
• “चक्षुषे हितं चक्षुष्यं”(डल्िण,सु.सू ४५/१३२)
That which is good for Chakshu is Chakshushya.
• “यत् जरा व्याधि विद्िम्सि ियिहा स्तंभकरकं तथा
चक्षुष्यं बृह्मनं िृष्यं भेषजं तद् रिायनं इतत” (Bha.P)
As per Bhavaprakasha the drugs that are Chaksushya and
Indriya balapradha can be advocated as Rasayana in order to
arrest the progression of already existing disease and prevent
occurrence of new disease which forms the Comprehensive
discipline of positive health
WHY ANALYSIS OF CHAKSHUSHYA
DRAVYAS IS NECESSARY??
CHAKSHUSHYA DRAVYAS
• ACC.TO RAJA NIGHANTU:
1. Karpara
2. Raktachandana
3. Kasturi
4. Lavanga
5. Prapoundarika
ACC.TO VANGASENA:
1. Triphala
2. Ghrita
3. Madhu
4. Yawa
5. Shatavari
6. Mudga
ACC.TO YOGARATNAKARA
(Netra:434,435)
1. Ghrita 11)Meghanada
2. Ksheera 12)Patola
3. Saindava 13)Godhuma
4. Madhu 14)Mudga
5. Jeevanti 15)Sitaa
6. Matsyakshi 16)shaali
7. Punarnava
8. Masha
9. Triphala
10. Lodhra
ACHARYA SUSHRUTHA & VAGBHATA:
(A.S.U16/30)
1. Triphala 7) Shatavari
2. Ghrita 8)Shighru
3. Ksheera 9)Yawa
4. Dadima 10)Patola
5. Draksha 11)Kaaravellaka
6. Amalaki
RASA RATNA SAMUCCHAYA
1. Swarna- चक्षुष्यं आयुष्रदं
2. Abhraka-चक्षुष्यं
3. Tamra-नेत्रामयेषु उत्तमं
4. Vanga-चक्षुष्यं
5. Yasada-नयनामय नाशकरं
6. Loha-लेखनं च अतत नेत्र्यं
7. Swarna makshika-चक्षुष्यं
8. Tutta-चक्षुषः
9) Kharpara-चक्षुष्यं
10)Kasisa-नेत्र्यमतुलः
11)Srotanjana-नेत्रामयतनशूदनं
12)Swarna gairika-लोचनयोहिितं
13)Kapardika-नेत्रदोष तनकृ न्तनः
14)Khati-नेत्ररोग तनकृ न्तातन
Rasa, virya, vipaka and doshaghnata of
chakshushya dravyas
Sl.no Name Lat Name Rasa Veerya Vipaka Doshagnata
1 Amalaki Emblica
officinalis
Pancha
rasa
Sheeta Madhura Tridoshahar
2 Bibhitaki Terminalia
bellirica
Pancha
rasa
Ushna Madhura Tridoshahar
3 Haritaki Terminalia
chebula
Pancha
rasa
ushna Madhura Tridoshahar
4 Draksha Vitis
vinifera
Madhur
a
sheeta madhur
a
Vata pitta
5 Jeeraka Cuminum
cyminum
katu ushna katu kaphavata
6 Jeevanti Leptadenia
reticulatae
madhur
a
sheeta madhur
a
tridoshahar
7 Kakamachi Solanm
nigrum
Katu,
tikta
anushn
a
katu tridoshahar
8 Karpura Cinnamon Madhur sheeta katu tridoshahar
Sl.no Name Lat Name Rasa veerya Vipaka Doshagnata
11
LATAKARANJA
Fibiscus
abelmosc
hus
Tikta,madh
ura
ushna katu tridoshahara
12 LAVANGA
Syzygium
aromaticu
m
Katu,tikta sheeta katu Kapha pitta
13 LODHRA
Symploco
cus
racemosa
kasaya sheeta katu Kapha pitta
14 MUGDHA
PARNI
phaseolus
trilobus
tikta sheeta madhur
a
tridoshahara
15 NIMBA PATRA
Azadirach
ta indica
Tikta,kash
aya
sheeta katu Kapha,pitta
16 NIRGUNDI
vitexnirgu
ndo
Katu,tikta
kashaya
ushna katu Kaphavata
17 PUNDARIKA
Nelumbo
nucifera
Madhura
,tikta
kasaya
sheeta madhur
a
tridoshahara
Sl.no Name Lat Name Rasa veerya Vipaka Doshagnata
21 YASHTIMADHU
Glycyrrhiz
a glabra
Madhura sheeta madhur
a
Vata pitta
22 PIPPALI
Piper
longum
Katu sheeta madhur
a
Vata kapha
23 PUNARNAVA
Boehavia
diffusa
Madhura,
tikta,kasa
ya
ushna katu Vata kapha
24 MADHU
25 SAINDAVA
26 GHRITA
27 SHIGHRU
Moringa
pterygosp
erma
Katu,tikta ushna katu Kapha vata
28 DUGDHA
MATYAKSHI
Sl no Name LATIN
NAME
RASA VIRYA VIPAKA DOSHAGH
NATA
31 BHRINGARAJA ECLIPTA
ALBA
Katu,tikta ushna KATU KAPHAVA
TA
32 MUDGA VIGNA
RADIATA
MADHURA
KASHYA
SHEETA KATU KAPHA
PITTA
33 RAKTA SHALI
34 GODHUMA
35 SITAA
• Tridosha shamaka
Kapha pitta shamaka
Kapha shamaka
Pitta shamaka
In this order dravyas should be selected
TRIPHALA
It is mentioned as CHAKSHUSHSYA by
Chakradatta ,Shushruta,Bhavaprakasha
and others.
Constituents:chebulic acid, gallic acid,
vit.C,Tannins and gallo-tanic acid.
Mode of action: It has greater free radical
scavenging activity among other actions
• The phytochemical analysis of Triphala revealed that
it contains phenolic acids and polyphenolic
compounds, tannins along with galic acid, flavinoids,
kempferol, etc which in turn generates actions like
anti-oxidants, radiation protecting ability, free
radical scavenging effect, cytoprotective and anti
mutagenic activity which are beneficial for eye
• RESEARCH:Triphala in Cataract (Gupta SK),Diabetic
Retinopathy(Lu et.al),ARMD(Ponu Shankar et al)
• Indication: Conjunctivitis, Progressive
myopia, Cataract and other degenerative
conditions
SHIGRU
It is mentioned as CHAKSHUSHYA by chakradatta
and Bhavaprakasha in Guduchyadi varga.
Constituents: has 46 natural antioxidants,
beta-carotene, vitamin A, vitamin B,
calcium, minerals like iron, magnesium, potassium, zinc, balmitic
linoleic, and carpic acid.
Mode of action: Antioxidants, Scavenges free radicals,Zinc helps in
absorption of iron, copper, Vit A.
Indications: Vataja, pittaja, kaphaja netra rogas.
SHATAVARI
It has been mentioned as CHAKSHUSHYA
by Chakradatta, BALYA, VAYASTHAPANA AND
MADHURASKANDA by Charaka
Constituents: Rich in sitosterol, thiamine, Vitamin A,C,B6,
Apargamins and Glutathione.
Mode of action:it is a good immune booster and Maintains
normal structure of cells.
Indication: Drishtimandhya
RAKTHACHANDANA
It has been mentioned as CHAKSHUSHSYA by
chakradatta and Bhavaprakasha.
Constituents: santalin a, b pterocarptiol,
pterocarpodiolone, lupenediol, homopterocarpin
Mode of action: haemostatic action.
Indication: Rakta, Pitta and Vataja Vyadhis.
Administration: Can be applied as lepa in digital users
when the eyes are stressed and in haemorrhagic
disorders.
It is one of the ingredient of Mahavasakadi Kwatha and
pundareekadi seka indicated for sarvanetrarogas.
SAINDHAVA LAVANA
It has been mentioned as CHAKSHUSHYA by
chakradatta, charaka.
constituents: Iodine, lithium, magnesium,
phosphorus, potassium, manganese, iron,
zinc, etc
Mode of action: It has hypertonic and hyperosmolar property
which helps to maintain the normal hydration of corneal surface
Indication: Shushkakshipaka.
Administration:
Saindhava ksheera seka in diseased conditions
BRINGARAJA
It is mentioned as CHAKSHUSHYA by
Bhavaprakasha and Raja nighantu.
Constituents: ecliptic, wedelolactone,
stigmosterol,heptacosanol,hentriacontanol, sixteen
polycetylentic thiophenes etc.
Mode of action: Stigmasterol hepatacosanol-acts
as immunomodulater by inhibiting the cell death.
Ecliptus sapanin c is a promoter of cell
regeneration.
Administration: Brhingaraja taila nasya in
cataract to improve vision and arrest the further
progression
YASHTI MADHU
It has mentioned as CHAKSHUSHYA
Raja nighantu Bhavaprakasha and JEEVANEEYA
by Charaka.
Constituents: glycyrrhizin, glycyrrhizic acid,
liquirtin, glabrene, saponin, liquiritic acid…
Mode of action: Saponin of yashtimadhu
increaseas the body’s Utilization of Calcium and
silicon
Indications:vataja pittaja netra rogas
Administration: Along with ghrita in
degenerative condition of the eyes.
Yashtimadhu kseera seka in Dry eyes and other
haemorrhagic disorders.
DUGDHA
It has mentioned as CHAKSHUSHYA
by Chakradatta. Also kseera is JEEVANEEYA and
BRIMHANEEYA.
Constituents: contains Vit. A, Vit. D, Thiamine, Riboflavin,
nicotinic acid.
Mode of action: helps to maintain the good vision and Vit A
is important for growth and development and for the
maintenance of immune system.
Retinol of Vit. A combines with protein opsin to form
rhodopsin.
Indication: Dry eye syndrome,Abhishyanda
Administration: Regularly along with Shatavari.
with the combination of drugs ksheera seka, and ksheera
sadhita ghritha for Tarpana in Dry eye syndrome and
degenerative conditions where pitta is associated.
MADHU
It is mentioned as chakshushya by Chakradatta.
Constituents: Aspigenin,pinocembrin,
kaempferol,quercetin,galangin,chrysin,
ellagic,caffeic acid, superoxide dismutase,
ascorbic acid, tocopherols.
Mode of action: Anti-Oxidants.
Indication: All the eye diseases fall under one name
Timira
Administration: Can be taken internally in limited
dosage regularly, Souveranajana and Srotoanjana
explained in dinacharya has madhu and regular use of
it helps to maintain structural and functional integrity
of the Eyes
.
Anjana which is indicated for all the netra rogas madhu
is a prime ingredient.
DRAKSHA
• Chakshushya-bhavaprakasha
• Constituents:Catechin,Epi-
catechin,flavanone,B-
sitosterol,Ergosterol,Vitamin E,
Resveratol,Jasmonic acid
Mode of action:Improves the health of blood
vessels.
Rich in flavanone- increases the arterial
function and used in arterial stiffness.
PIPPALI
• Chakshushya – Bhavaprakasha
• Constituents:Caryophyllene,piperine,ses
amin,B-sitosterol
• Mode of action:Improves the availability
of medicine for absorption.
• Research: Antibacterial,Anti allergic
activities are proven.
PUNARNAVA
• Constituents:Alkaloids,steroids,
flavonoids,retenoids,B-sitosterol,stearic
acid,arachidic acid,amino acids
• Mode of Action: Alkaloids – relieves
spasms, dry up secretions, analgesic effect
and dilates pupils
LODHRA
Constituents:Alkaloids,Phenolic glycosides,Flavanol
glycosides,Triterpenoids,C-glycosides
MODE OF ACTION:
Methanol extrats of leaves –Anti inflammatory activity
Ethanolic extracts –Antibacterial activity
Anti oxidant property and radical scavenging effect has
been proven.
JEEVANTI
• Charaka-Jeevaneeya,Madhura skanda
• Sushruta-kakolyadi
• Vagbhata-Jeevaneeya
• Bha.p-Guduchyadi varga
• Constituents:Beta sitosterol,cetyl
alcohol,n-triacontne,beta amyrin
acetate,leptidin glycoside
• Mode of Action: Anti oxidant, Anti fungal
RESEARCH : 1)The total anti oxidant potential was
estimated by 3 different models
diphenylpicrylhydrazyl free radical scavenging
activity.
2)Invitro fungal activity has been studied against
selected strains and proven.
GHRITA
Ghee is a potent medicine.
• The chemical analysis of ghee shows good quality of
unsaturated fats which helps in the nourishment of
neurons of brain preventing ocular neuro
degenerative diseases.
• Omega 3 and omega 4 fatty acids which are very
essential for vision.
LOHA(IRON)
1. It is an essential component of cellular
metabolism.
2. In lens increased expression of H-ferritin
(one of iron complex stored in cell)in
epithelial cells decreases the amount of
intra cellular free iron and improves
cellular defense against oxidative stress.
3. The RPE enzyme RPE 65 converts 11 cis
retinal to al trans retinyl as part of the
retinoid cycle necessary for
phototransduction, requires iron.
GANDHAKA(SULPHUR)
1. Sulphur is required for proper structure
and biological activity of enzymes.
2. It plays a major role in electron transport
system.
3. It synthesize Glutathione, mother of all
anti-oxidants.
4. Present in choroid, lens,aqeous part of
tear.
METHYLSUFONYLMETHANE
• Organic form of Sulphur and
potent antioxidant.
• Naturally found in
onion,garlic,nuts,milk,egg.
• Improves cellular uptake of many
nutrients Vitamin A,B,C,D,E &
amino acids.
• Prevents Neurological diseases
by repairing oxidative damage
and restoring cell membrane
elasticity.
ABHRAKA
• It is a complex of hydrous silicate of
aluminium containing K,Mg,Fe,Na, and
traces of Ca.
• Having high penetrating spreads in the
body at a faster rate and impacts micro
tissues quickly.
• Helps in cell regeneration and also
improves blood circulation.
YASHADA
• Zinc is a essential trace mineral or helper
molecule.
• It plays a vital role in bringing Vitamin A
from the liver to the retina in order to
produce melanin,a protective pigment in
the eyes.
• It is believed to be important for vision
because high levels of zinc are found in
the macula.
TAMRA
• Acts as co-factor for enzymes making a
metallo enzyme complex.
• Catalyzes the reduction-oxidation reactions.
• Stimulates the immune cells.
• Present in Retina but concentration is lesser
than Zinc.Promotes uptake of Iron & zinc in
the body.
• Copper is present in the retina where it
functions as REDOX as a co-factor for enzyme
copper,zinc ;superoxide
dismutase(antioxidant enzyme)
PARADA(MERCURIC OXIDE)
• In organic chemistry,mercuric sulphate is
used as a catalyst.
• Mercuric salts helps in the uptake of metal
complexes into the cell.
• It improves the other drug action.
• Parada acts a Yogavahi(Synergistic action)
and also has Rasayana (rejuvenating)
effect.
SWARNA
• Has excellent radical scavenging activity.
• Research also revealed that it acts on
ischemic conditions in the brain.
• Proved to be a nootropic drug which works
by increasing the oxygen supply to the
neuro chemicals.
• Also increases oxygen supply to brain and
also has stimulatory nerve growth.
MODE OF ACTION OF
CHAKSHUSHYA DRAVYAS
1. Immuno modulatory action of drugs is an
effective as well as protective approach
in many eye disorders whether primary
or secondary like Retinopathy,
Uveitis,ARMD.
2. Presence of Glutathione and ascorbate
does Anti-aging action and does the
physiological protection against the
oxidative damage of lens and helps to
maintain transparency of lens.
3.Nutrients like Vitamin A,C,B1,
B2,B12,B6,vitamin D,b-carateoids,cystine present
in chakshushya dravyas ,protect the Eyes from
free radical damage and prevents diseases lke
macular degeneration.
4.The content like polyphenols and tannins are
responsible for Radio protecting ability in the
diseases like Pterygium, Catarct, Catarrhal
conjunctivitis.
5.Presence of Zinc helps to store Vitamin A in
Retina.
6.The role of super oxide dismutase of drugs also
catalyzes dismutation of superoxide radical in an
ordinary molecular oxygen by maintaining
physiology of Eye and rebuilt ageing process and
extending length of that particular tissue.
7.Anti oxidants inhibits the oxidation process.
DRISHTIHITAKARA AHARA
karavellaka draksha
mudga
sitha godhuma Rakta shali matsyakshi
grithakaravellaka gritha
draksha
karavellaka gritha
RECENT RESEARCH WORKS
1)AMALAKI
• Pyruvate & Vitamin C present in
E.Officinale found to inhibit Aldose
reductase and reduce lens sorbitol levels.
(S.K Gupta,etal,Indian journal of
ophthalmology.2009/57:175-183)
• Amla is a potent inhibitor of Lipid peroxide
formation and scavenger of superoxide and
Hydroxyl radicals Invitro & are capable to
prevent dyslipidaemia and Oxidative stress in
the Ageing process.
(TokatoYokozova,et.al ,British Journal of
Nutrition.2007/97,1187-1195
• The Anti-Oxidant activity of the Amla is superior
to Vitamin-C due to the presence of low
molecular hydrolysable tannins-emblicanin A
&emblicanin B
(Ghosal,S.et.al,Ind.J.Chem.1996,35B,941-948)
• E.Officinalis is capable to induce Lens
regeneration in the frog,
RanaCyanophlyctis(Banot,J.et.al,Ind.J.Exp.Bio
2009,March;47(3);157-62)
2)HARITAKI
• 6 Extracts and 4 pure compounds from the Drug
exhibited Anti-lipid peroxidation, Anti-
superoxide radical formation and free radical
scavenging activities in experimental animals.
(Hwa-Yew-Cheng et.al.Bio.Pharm.Bull.2005,26(9)
1331-1335)
• Methanolic extract of the drug has been
suggested to play a major role in the relief of
long term complications of DM in
Experimental animals due to the oxidative
stress.
(Sabu,MC,Kuttan,R.
J.ethnopharmacol,2006,81,155-160)
• Its Anti Cancer, Anti-Diabetic, Anti-
Mutagenic and Anti Viral activities are
attributed to its Anti-Oxidant Properties.
3)BIBHEETAKI
• Fruit Extract showed anti diabetic and
anti oxidant properties in vivo.
(Sabu,MC,Kuttan,R.
Ind.J.Exp Biol,2009,April,47(4)270-5)
4)TRIPHALA
• Lipid Peroxidation and plasmid DNA assay with
greater free radical scavenging activity.
• Thus its more effective.
(Naik,GH,et.al ; In vitro anti oxidant studies and
free radical reactions of Triphala, Phytother
Res.2005,July,19(7)582-6)
5)HARIDRA
• Cucurmin along with Ag reduced oxidative
stress and cataract in Invitro, possibly by
inhibiting depletion of enzymatic as well as non
enzymatic anti oxidants.
(Maniknandan,R.et.al.ChemBiol Interact:2009,Oct
7;181(2) 2002-9)
• May have an inhibitory effect on
corneal neo vascularisation, both in
vitro and in vivo.
• The VEGF expression was found to reduce.
(Bian,F.et.alOphthalmologica 2008;222(3)
178-86)Mridula,T et.al BiochemBiophys res
commun,2007,Sep.21; 361(2)528-32)
• Preventive against Diabetic cataract along
with Vitamin.E;A toxic antioxidant and a
powerful chemo preventive agent;increases
the bio availability of Vitamins.especially
Vitamin E (Raju,T.N;et.al Indian Exp Biol.2006,
Sep.44(9);733-9)
7)MADHU
• Contains almost all Micro-Nutrients.
• Twenty fold Anti-oxidant capacity (water
solution)than Vitamin C and Richest supplier of
Anti-oxidant.
• Clinical trial in Senile cataract with Installation
of Honey in varying doses proved beneficial.
(Golychev,V.N;Vestn Oftalmol,1990,Nov-
Dec,106(6);59-62)
8)ZINC
• Recently Zinc supplements is given to
treat and prevent the ARMD.
• Researchers have suggested that the Zinc
and anti-oxidants delay the progression of
ARMD and vision loss,possibly by
preventing cellular damage in the retina.
ANTI OXIDANTS AND EYE
• ACC.to AOA,
• The nutrition and vision project found that
higher intake of vitamin C led to a reduced
risk of cortical and nuclear cataract.
• Results shoed that people who used
vitamin C & E supplements for more than
10 years had decreased progression of
nuclear cataract.
ARMD:
• Vitamin & Mineral formulation could
be improved by adding
lutein,zeaxanthin,or Omega-3 fatty
acids and thereby reduced risk of
ARMD.
DISCUSSION
• Acharya Charaka told,
“चक्षुस्तेजोमयं तस्य विशेषात् श्लेष्मतो
भयम ्”
Chakshu is the chief site for Alochaka
pitta but special protection Is required
against he Kapha,because kapha dosha is
opposite to Teja mahabhoota in
reference to their Guna.
• So chakshushya dravyas should be
Kaphashamaka and pittavardhaka.
• But pitta is Aadanakaraka and it will
cause Chakshu indriya balahrasa.
• So chakshushya dravyas should be having
property of balancing all the 3 doshas
especially keeping the pitta kapha
saamya.
i.e Kapha shamaka but without disturbing
the pitta saamyata.
The function of Chakshuindriya is done by Alochak
pitta. So exposure to all Shitaviryadravyas and
conditions should be avoided because they will
vitiate the kapha.
• Ushnaviryadravyas should be good for Chakshu.
But this is not so simple as it looks.
• Virtually, Pitta causes Indriyabalahrasa due to its
aadanakaarak property while kapha is
indriyabalavraddhikarak due to its visargakaraka
quality.
• Both these things seems contrary to each
other. On the basis of above discussion it is
clear that Chakshushyadravyas should be
Pitta-Kaphashamak.
• Tridoshashamakdravyas could be first
choice, followed by Pitta-Kaphashamak then
Kaphashamak and in last Pitta shamak
• So these dravyas will do their action by
Kaphashamana without disturbing the Pitta
samyata as written in Charak Samhita-
“Shleshmaharkarmamhitadrushteheprasadana
m”.
• As already mentioned by BhavaprakashaNighatu
that being beneficial or being harmful depends
upon the DRAVYA itself, not the properties
• Ex: AMALAKI and LAKUCHA having same properties
become tridosha shamaka and tridosha kopaka
respectively.
• Medicated grithas, bhasma of gold,
copper, zinc and calcium etc. which
are absorbed systemically are
administered orally to fulfill the
essentials of eye metabolism.
• Herbo mineral compound
preparations like Saptamritalauha,
Netraarshini rasa, Mahatriphalagritha
etc. are also advocated systemically
• Eye care professionals have long encouraged
patients to eat a healthy, well-balanced diet
containing antioxidants, green leafy vegetables,
Omega-3 fatty acids, and betacarotene.
• Benefits of such diet helps to protect against
diseases such as cancer and diabetes.
• It's also important to avoid foods that have been
proven to damage the eyes, such as saturated fats
and aspartame.
• Recent studies have examined the role of
nutritional supplements in supporting eye
health and treating eye disorders.
• A combination of Vitamins A, C, and E, plus
betacarotene supplements and zinc has been
recommended by the National Eye Institute in
the US as beneficial for patients with early
signs of macular degeneration
• Current studies show that macular
degeneration can be slowed or reversed by
supplementing the diet with a combination
of xanthophylls: lutein, zeaxanthin, and
meso-zeaxanthin.
• In conjunction with antioxidant vitamin, zinc
and Omega-3 supplementation, carotenoid
supplements are now considered to be an
essential part of a treatment regimen for
MD.
• Along with supplementation, lifestyle changes
may be incorporated for those at risk of
developing the advanced form of this disease.
DRAVYAS PROBABLE MODE OF
ACTION
POPULAR
MEDICATIONS
DUGDHA VISUAL
PHOTOTRANSDUCTION
,SCOTOPIC VISION
BASE FOR ALL GHRITA
PREPARATIONS & IN
KRIYA KALPAS
MADHU POTENT ANTIOXIDANT BASE FOR ALL THE
ANJANAS
SAINDAVA MAINTAINS THE
NORMAL HYDRATION
OF CORNEAL SURFACE
KSHEERA SAINDAVA
SEKA IS A POTENT
SHOOLAHARA IN
SHUKSHAKSHIPAKA
GHRITA POTENT ANTI OXIDANT
NEURO
DEGENERATION
BASE FOR ALL THE
KRIYAKALPAS AS ITS
SAMSKARASYA
ANUVARTANAT
PIPPALI BETA-SITOSTEROL
ACTS AS VEHICLE FOR
DRUG TO REACH ITS
TARGET & POTENT ANTI
BACTERIAL & ANTI
USED IN MANY
ANJANAS TO
ACCELERATE THE
ACTION OF DRUG
KRIYA KALPA-CHAKSHUSHYA DRAVYAS
DRAVYAS PROBABLE MODE OF
ACTION
POPULAR MEDICATIONS
TRIPHALA POTENT ANTIOXIDANT BEST CHAKSHUSHYA-IN
ALL KRIYAKALPAS
SHIGRU ANTI OXIDANT,
REJUVENATES CELLS OF
LENS
ARKA,SWARASA FOR
ASCHYOTANA
SHATAVARI ANTI OXIDANT, ANTI
HAEMORRHAGIC,
ANALGESIC
USED AS KSHEERA PAKA
& DIFFERENT KRIYA
KALPAS
RAKTACHANDANA POTENT HAEMOSTATIC LEPA & SEKA
BHRINGARAJA ACTS BY
SAPONIFICATION-
IMMUNO MODULATORY,
PREVENTS CELL DEATH,
PROMOTES CELL
GROWTH
TAILA NASYA IN
CATARACT,-TILA TAILADI
NASYA -TIMIRA IS
PROVED EFFECTIVE
DRAVYAS PROBABLE MODE OF
ACTION
POPULAR
MEDICATIONS
PUNARNAVA ANTI
SPASMODIC,ANALGE
SIC, DIURETIC
ACTS AS
SHOTHAHARA WHEN
USED IN DIFFERENT
KRIYAKALPAS
LODHRA ANTI INFLAMMATORY,
ANTIBACTERIAL,FLAV
ANOIDS
RAKTA PRASADAKA
GANA AS PER
CHARAKA,
INCORPORATED IN
ALL KRIYAKALPAS
JEEVANTI ANTI FUNGAL,ANTI
OXIDANT,
JEEVANIYA DRAVYA
USED IN VARIOUS
GHRITA,
TAILA,PAYASA
PREPARATIONS
RASA DRAVYA PROBABLE MODE OF
ACTION
MEDICATIONS
SWARNA NOOTROPHIC –
STIMULATES THE
NERVES
BHASMA,POTTALI-
ORALLY
LOHA PHOTOTRANSDUCTION,
PREVENTS OXIDATIVE
STRESS-LENS
SAPTAMRITA LOHA
GANDHAKA MOTHER OF ALL ANTI
OXIDANTS-
SYNTHESIZES
GLUTATHIONE,COMPONE
NT OF
CHOROID,LENS,TEAR
FILM
GANDHAKA RASAYANA
PARADA YOGAVAHI-CAN BE
CONSUMED
THROUGHOUT ONE’S
LIFE FOR LONGEVITY-
ANANDAKANDA
RASA SINDHURA-
CHAKSHUSHYA
TAMRA INCREASES UPTAKE OF
IRON AND ZINC
TAMRA GARBHA POTTALI
RASAYANA
CONCLUSION
The various chakshusya dravyas mentioned in our classics are
rich sources of Macro and micro nutrients like sorbitol,
glucose, fructose, glycogen, mucoprotein , calcium, zinc,
glutathione, vitamin A, vitamin E, Vitamin C, Vitamin K,
Vitamin B1 B2 B6 B12 ,Vitamin D helps in maintaining normal
function s,tuctural intrigity of the eye .
Practicing / intake of chakshusya rasayana helps to
prevent the eye disorders which can be prophylactic
in many highly prevalent life style disorders in turn
which causes pathological changes in eyes.
SCOPE FOR FURTHER STUDY
1. Pharmacological and clinical work should
be done to evaluate the chakshushya
property of these drugs.
2. Phytochemical analysis of these dravyas
should be done and responsible
ingredients should be furher studied for
chakshushya activity.
Chakshusya dravyas

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Chakshusya dravyas

  • 2. CONTENTS  INTRODUCTION  WHY ANALYSIS OF CHAKSHUSHYA DRAVYAS IS NECESSARY??  CHAKSHUSHYA VERSES RASAYANA.  CHAKSHUSHYA DRAVYAS.  MODE OF ACTION OF CHAKSHUSHYA DRAVYAS  DISCUSSION.  CONCLUSION.
  • 3. INTRODUCTION • Every Human wishes to have a long, happy and healthy life. • To fulfill this they tend to work hard which makes them stressed, irregular and non- nutritive food habits,irregular sleep pattern which brings stress on mind and eyes-all these reduces the longevity of each individual..
  • 4. • Apart, Newer organisms, Environmental changes have also caused tremendous reduction in the quality of life. • Pertaining to eyes Cataract, ARMD, Degenerative myopia,Early changes in eye due to Diabetes,HTN etc.are major challenging disorders. • The present era is also witnessing new disorders like corneal epithelial erosion syndrome, Dry eye syndrome,smart phone syndrome and along with changing pattern of existing disorders.
  • 5. • So to overcome from all these disorders, chakshushya dravyas and chakshu kamya rasayanas are helpful.
  • 6. chakshushya?? • “चक्षुषे हितं चक्षुष्यं”(डल्िण,सु.सू ४५/१३२) That which is good for Chakshu is Chakshushya. • “यत् जरा व्याधि विद्िम्सि ियिहा स्तंभकरकं तथा चक्षुष्यं बृह्मनं िृष्यं भेषजं तद् रिायनं इतत” (Bha.P) As per Bhavaprakasha the drugs that are Chaksushya and Indriya balapradha can be advocated as Rasayana in order to arrest the progression of already existing disease and prevent occurrence of new disease which forms the Comprehensive discipline of positive health
  • 7. WHY ANALYSIS OF CHAKSHUSHYA DRAVYAS IS NECESSARY??
  • 8. CHAKSHUSHYA DRAVYAS • ACC.TO RAJA NIGHANTU: 1. Karpara 2. Raktachandana 3. Kasturi 4. Lavanga 5. Prapoundarika
  • 9. ACC.TO VANGASENA: 1. Triphala 2. Ghrita 3. Madhu 4. Yawa 5. Shatavari 6. Mudga
  • 10. ACC.TO YOGARATNAKARA (Netra:434,435) 1. Ghrita 11)Meghanada 2. Ksheera 12)Patola 3. Saindava 13)Godhuma 4. Madhu 14)Mudga 5. Jeevanti 15)Sitaa 6. Matsyakshi 16)shaali 7. Punarnava 8. Masha 9. Triphala 10. Lodhra
  • 11. ACHARYA SUSHRUTHA & VAGBHATA: (A.S.U16/30) 1. Triphala 7) Shatavari 2. Ghrita 8)Shighru 3. Ksheera 9)Yawa 4. Dadima 10)Patola 5. Draksha 11)Kaaravellaka 6. Amalaki
  • 12. RASA RATNA SAMUCCHAYA 1. Swarna- चक्षुष्यं आयुष्रदं 2. Abhraka-चक्षुष्यं 3. Tamra-नेत्रामयेषु उत्तमं 4. Vanga-चक्षुष्यं 5. Yasada-नयनामय नाशकरं 6. Loha-लेखनं च अतत नेत्र्यं 7. Swarna makshika-चक्षुष्यं 8. Tutta-चक्षुषः
  • 14. Rasa, virya, vipaka and doshaghnata of chakshushya dravyas Sl.no Name Lat Name Rasa Veerya Vipaka Doshagnata 1 Amalaki Emblica officinalis Pancha rasa Sheeta Madhura Tridoshahar 2 Bibhitaki Terminalia bellirica Pancha rasa Ushna Madhura Tridoshahar 3 Haritaki Terminalia chebula Pancha rasa ushna Madhura Tridoshahar 4 Draksha Vitis vinifera Madhur a sheeta madhur a Vata pitta 5 Jeeraka Cuminum cyminum katu ushna katu kaphavata 6 Jeevanti Leptadenia reticulatae madhur a sheeta madhur a tridoshahar 7 Kakamachi Solanm nigrum Katu, tikta anushn a katu tridoshahar 8 Karpura Cinnamon Madhur sheeta katu tridoshahar
  • 15. Sl.no Name Lat Name Rasa veerya Vipaka Doshagnata 11 LATAKARANJA Fibiscus abelmosc hus Tikta,madh ura ushna katu tridoshahara 12 LAVANGA Syzygium aromaticu m Katu,tikta sheeta katu Kapha pitta 13 LODHRA Symploco cus racemosa kasaya sheeta katu Kapha pitta 14 MUGDHA PARNI phaseolus trilobus tikta sheeta madhur a tridoshahara 15 NIMBA PATRA Azadirach ta indica Tikta,kash aya sheeta katu Kapha,pitta 16 NIRGUNDI vitexnirgu ndo Katu,tikta kashaya ushna katu Kaphavata 17 PUNDARIKA Nelumbo nucifera Madhura ,tikta kasaya sheeta madhur a tridoshahara
  • 16. Sl.no Name Lat Name Rasa veerya Vipaka Doshagnata 21 YASHTIMADHU Glycyrrhiz a glabra Madhura sheeta madhur a Vata pitta 22 PIPPALI Piper longum Katu sheeta madhur a Vata kapha 23 PUNARNAVA Boehavia diffusa Madhura, tikta,kasa ya ushna katu Vata kapha 24 MADHU 25 SAINDAVA 26 GHRITA 27 SHIGHRU Moringa pterygosp erma Katu,tikta ushna katu Kapha vata 28 DUGDHA MATYAKSHI
  • 17. Sl no Name LATIN NAME RASA VIRYA VIPAKA DOSHAGH NATA 31 BHRINGARAJA ECLIPTA ALBA Katu,tikta ushna KATU KAPHAVA TA 32 MUDGA VIGNA RADIATA MADHURA KASHYA SHEETA KATU KAPHA PITTA 33 RAKTA SHALI 34 GODHUMA 35 SITAA
  • 18. • Tridosha shamaka Kapha pitta shamaka Kapha shamaka Pitta shamaka In this order dravyas should be selected
  • 19. TRIPHALA It is mentioned as CHAKSHUSHSYA by Chakradatta ,Shushruta,Bhavaprakasha and others. Constituents:chebulic acid, gallic acid, vit.C,Tannins and gallo-tanic acid. Mode of action: It has greater free radical scavenging activity among other actions
  • 20. • The phytochemical analysis of Triphala revealed that it contains phenolic acids and polyphenolic compounds, tannins along with galic acid, flavinoids, kempferol, etc which in turn generates actions like anti-oxidants, radiation protecting ability, free radical scavenging effect, cytoprotective and anti mutagenic activity which are beneficial for eye • RESEARCH:Triphala in Cataract (Gupta SK),Diabetic Retinopathy(Lu et.al),ARMD(Ponu Shankar et al) • Indication: Conjunctivitis, Progressive myopia, Cataract and other degenerative conditions
  • 21. SHIGRU It is mentioned as CHAKSHUSHYA by chakradatta and Bhavaprakasha in Guduchyadi varga. Constituents: has 46 natural antioxidants, beta-carotene, vitamin A, vitamin B, calcium, minerals like iron, magnesium, potassium, zinc, balmitic linoleic, and carpic acid. Mode of action: Antioxidants, Scavenges free radicals,Zinc helps in absorption of iron, copper, Vit A. Indications: Vataja, pittaja, kaphaja netra rogas.
  • 22. SHATAVARI It has been mentioned as CHAKSHUSHYA by Chakradatta, BALYA, VAYASTHAPANA AND MADHURASKANDA by Charaka Constituents: Rich in sitosterol, thiamine, Vitamin A,C,B6, Apargamins and Glutathione. Mode of action:it is a good immune booster and Maintains normal structure of cells. Indication: Drishtimandhya
  • 23. RAKTHACHANDANA It has been mentioned as CHAKSHUSHSYA by chakradatta and Bhavaprakasha. Constituents: santalin a, b pterocarptiol, pterocarpodiolone, lupenediol, homopterocarpin Mode of action: haemostatic action. Indication: Rakta, Pitta and Vataja Vyadhis.
  • 24. Administration: Can be applied as lepa in digital users when the eyes are stressed and in haemorrhagic disorders. It is one of the ingredient of Mahavasakadi Kwatha and pundareekadi seka indicated for sarvanetrarogas.
  • 25. SAINDHAVA LAVANA It has been mentioned as CHAKSHUSHYA by chakradatta, charaka. constituents: Iodine, lithium, magnesium, phosphorus, potassium, manganese, iron, zinc, etc Mode of action: It has hypertonic and hyperosmolar property which helps to maintain the normal hydration of corneal surface
  • 27. BRINGARAJA It is mentioned as CHAKSHUSHYA by Bhavaprakasha and Raja nighantu. Constituents: ecliptic, wedelolactone, stigmosterol,heptacosanol,hentriacontanol, sixteen polycetylentic thiophenes etc.
  • 28. Mode of action: Stigmasterol hepatacosanol-acts as immunomodulater by inhibiting the cell death. Ecliptus sapanin c is a promoter of cell regeneration. Administration: Brhingaraja taila nasya in cataract to improve vision and arrest the further progression
  • 29. YASHTI MADHU It has mentioned as CHAKSHUSHYA Raja nighantu Bhavaprakasha and JEEVANEEYA by Charaka. Constituents: glycyrrhizin, glycyrrhizic acid, liquirtin, glabrene, saponin, liquiritic acid… Mode of action: Saponin of yashtimadhu increaseas the body’s Utilization of Calcium and silicon
  • 30. Indications:vataja pittaja netra rogas Administration: Along with ghrita in degenerative condition of the eyes. Yashtimadhu kseera seka in Dry eyes and other haemorrhagic disorders.
  • 31. DUGDHA It has mentioned as CHAKSHUSHYA by Chakradatta. Also kseera is JEEVANEEYA and BRIMHANEEYA. Constituents: contains Vit. A, Vit. D, Thiamine, Riboflavin, nicotinic acid. Mode of action: helps to maintain the good vision and Vit A is important for growth and development and for the maintenance of immune system.
  • 32. Retinol of Vit. A combines with protein opsin to form rhodopsin. Indication: Dry eye syndrome,Abhishyanda Administration: Regularly along with Shatavari. with the combination of drugs ksheera seka, and ksheera sadhita ghritha for Tarpana in Dry eye syndrome and degenerative conditions where pitta is associated.
  • 33. MADHU It is mentioned as chakshushya by Chakradatta. Constituents: Aspigenin,pinocembrin, kaempferol,quercetin,galangin,chrysin, ellagic,caffeic acid, superoxide dismutase, ascorbic acid, tocopherols. Mode of action: Anti-Oxidants. Indication: All the eye diseases fall under one name Timira
  • 34. Administration: Can be taken internally in limited dosage regularly, Souveranajana and Srotoanjana explained in dinacharya has madhu and regular use of it helps to maintain structural and functional integrity of the Eyes . Anjana which is indicated for all the netra rogas madhu is a prime ingredient.
  • 35. DRAKSHA • Chakshushya-bhavaprakasha • Constituents:Catechin,Epi- catechin,flavanone,B- sitosterol,Ergosterol,Vitamin E, Resveratol,Jasmonic acid Mode of action:Improves the health of blood vessels. Rich in flavanone- increases the arterial function and used in arterial stiffness.
  • 36. PIPPALI • Chakshushya – Bhavaprakasha • Constituents:Caryophyllene,piperine,ses amin,B-sitosterol • Mode of action:Improves the availability of medicine for absorption. • Research: Antibacterial,Anti allergic activities are proven.
  • 37. PUNARNAVA • Constituents:Alkaloids,steroids, flavonoids,retenoids,B-sitosterol,stearic acid,arachidic acid,amino acids • Mode of Action: Alkaloids – relieves spasms, dry up secretions, analgesic effect and dilates pupils
  • 38. LODHRA Constituents:Alkaloids,Phenolic glycosides,Flavanol glycosides,Triterpenoids,C-glycosides MODE OF ACTION: Methanol extrats of leaves –Anti inflammatory activity Ethanolic extracts –Antibacterial activity Anti oxidant property and radical scavenging effect has been proven.
  • 39. JEEVANTI • Charaka-Jeevaneeya,Madhura skanda • Sushruta-kakolyadi • Vagbhata-Jeevaneeya • Bha.p-Guduchyadi varga • Constituents:Beta sitosterol,cetyl alcohol,n-triacontne,beta amyrin acetate,leptidin glycoside • Mode of Action: Anti oxidant, Anti fungal
  • 40. RESEARCH : 1)The total anti oxidant potential was estimated by 3 different models diphenylpicrylhydrazyl free radical scavenging activity. 2)Invitro fungal activity has been studied against selected strains and proven.
  • 41. GHRITA Ghee is a potent medicine. • The chemical analysis of ghee shows good quality of unsaturated fats which helps in the nourishment of neurons of brain preventing ocular neuro degenerative diseases. • Omega 3 and omega 4 fatty acids which are very essential for vision.
  • 42. LOHA(IRON) 1. It is an essential component of cellular metabolism. 2. In lens increased expression of H-ferritin (one of iron complex stored in cell)in epithelial cells decreases the amount of intra cellular free iron and improves cellular defense against oxidative stress. 3. The RPE enzyme RPE 65 converts 11 cis retinal to al trans retinyl as part of the retinoid cycle necessary for phototransduction, requires iron.
  • 43. GANDHAKA(SULPHUR) 1. Sulphur is required for proper structure and biological activity of enzymes. 2. It plays a major role in electron transport system. 3. It synthesize Glutathione, mother of all anti-oxidants. 4. Present in choroid, lens,aqeous part of tear.
  • 44. METHYLSUFONYLMETHANE • Organic form of Sulphur and potent antioxidant. • Naturally found in onion,garlic,nuts,milk,egg. • Improves cellular uptake of many nutrients Vitamin A,B,C,D,E & amino acids. • Prevents Neurological diseases by repairing oxidative damage and restoring cell membrane elasticity.
  • 45. ABHRAKA • It is a complex of hydrous silicate of aluminium containing K,Mg,Fe,Na, and traces of Ca. • Having high penetrating spreads in the body at a faster rate and impacts micro tissues quickly. • Helps in cell regeneration and also improves blood circulation.
  • 46. YASHADA • Zinc is a essential trace mineral or helper molecule. • It plays a vital role in bringing Vitamin A from the liver to the retina in order to produce melanin,a protective pigment in the eyes. • It is believed to be important for vision because high levels of zinc are found in the macula.
  • 47. TAMRA • Acts as co-factor for enzymes making a metallo enzyme complex. • Catalyzes the reduction-oxidation reactions. • Stimulates the immune cells. • Present in Retina but concentration is lesser than Zinc.Promotes uptake of Iron & zinc in the body. • Copper is present in the retina where it functions as REDOX as a co-factor for enzyme copper,zinc ;superoxide dismutase(antioxidant enzyme)
  • 48. PARADA(MERCURIC OXIDE) • In organic chemistry,mercuric sulphate is used as a catalyst. • Mercuric salts helps in the uptake of metal complexes into the cell. • It improves the other drug action. • Parada acts a Yogavahi(Synergistic action) and also has Rasayana (rejuvenating) effect.
  • 49. SWARNA • Has excellent radical scavenging activity. • Research also revealed that it acts on ischemic conditions in the brain. • Proved to be a nootropic drug which works by increasing the oxygen supply to the neuro chemicals. • Also increases oxygen supply to brain and also has stimulatory nerve growth.
  • 50. MODE OF ACTION OF CHAKSHUSHYA DRAVYAS 1. Immuno modulatory action of drugs is an effective as well as protective approach in many eye disorders whether primary or secondary like Retinopathy, Uveitis,ARMD. 2. Presence of Glutathione and ascorbate does Anti-aging action and does the physiological protection against the oxidative damage of lens and helps to maintain transparency of lens.
  • 51. 3.Nutrients like Vitamin A,C,B1, B2,B12,B6,vitamin D,b-carateoids,cystine present in chakshushya dravyas ,protect the Eyes from free radical damage and prevents diseases lke macular degeneration. 4.The content like polyphenols and tannins are responsible for Radio protecting ability in the diseases like Pterygium, Catarct, Catarrhal conjunctivitis. 5.Presence of Zinc helps to store Vitamin A in Retina.
  • 52. 6.The role of super oxide dismutase of drugs also catalyzes dismutation of superoxide radical in an ordinary molecular oxygen by maintaining physiology of Eye and rebuilt ageing process and extending length of that particular tissue. 7.Anti oxidants inhibits the oxidation process.
  • 53. DRISHTIHITAKARA AHARA karavellaka draksha mudga sitha godhuma Rakta shali matsyakshi grithakaravellaka gritha draksha karavellaka gritha
  • 54. RECENT RESEARCH WORKS 1)AMALAKI • Pyruvate & Vitamin C present in E.Officinale found to inhibit Aldose reductase and reduce lens sorbitol levels. (S.K Gupta,etal,Indian journal of ophthalmology.2009/57:175-183)
  • 55. • Amla is a potent inhibitor of Lipid peroxide formation and scavenger of superoxide and Hydroxyl radicals Invitro & are capable to prevent dyslipidaemia and Oxidative stress in the Ageing process. (TokatoYokozova,et.al ,British Journal of Nutrition.2007/97,1187-1195
  • 56. • The Anti-Oxidant activity of the Amla is superior to Vitamin-C due to the presence of low molecular hydrolysable tannins-emblicanin A &emblicanin B (Ghosal,S.et.al,Ind.J.Chem.1996,35B,941-948) • E.Officinalis is capable to induce Lens regeneration in the frog, RanaCyanophlyctis(Banot,J.et.al,Ind.J.Exp.Bio 2009,March;47(3);157-62)
  • 57. 2)HARITAKI • 6 Extracts and 4 pure compounds from the Drug exhibited Anti-lipid peroxidation, Anti- superoxide radical formation and free radical scavenging activities in experimental animals. (Hwa-Yew-Cheng et.al.Bio.Pharm.Bull.2005,26(9) 1331-1335)
  • 58. • Methanolic extract of the drug has been suggested to play a major role in the relief of long term complications of DM in Experimental animals due to the oxidative stress. (Sabu,MC,Kuttan,R. J.ethnopharmacol,2006,81,155-160)
  • 59. • Its Anti Cancer, Anti-Diabetic, Anti- Mutagenic and Anti Viral activities are attributed to its Anti-Oxidant Properties.
  • 60. 3)BIBHEETAKI • Fruit Extract showed anti diabetic and anti oxidant properties in vivo. (Sabu,MC,Kuttan,R. Ind.J.Exp Biol,2009,April,47(4)270-5)
  • 61. 4)TRIPHALA • Lipid Peroxidation and plasmid DNA assay with greater free radical scavenging activity. • Thus its more effective. (Naik,GH,et.al ; In vitro anti oxidant studies and free radical reactions of Triphala, Phytother Res.2005,July,19(7)582-6)
  • 62. 5)HARIDRA • Cucurmin along with Ag reduced oxidative stress and cataract in Invitro, possibly by inhibiting depletion of enzymatic as well as non enzymatic anti oxidants. (Maniknandan,R.et.al.ChemBiol Interact:2009,Oct 7;181(2) 2002-9)
  • 63. • May have an inhibitory effect on corneal neo vascularisation, both in vitro and in vivo. • The VEGF expression was found to reduce. (Bian,F.et.alOphthalmologica 2008;222(3) 178-86)Mridula,T et.al BiochemBiophys res commun,2007,Sep.21; 361(2)528-32)
  • 64. • Preventive against Diabetic cataract along with Vitamin.E;A toxic antioxidant and a powerful chemo preventive agent;increases the bio availability of Vitamins.especially Vitamin E (Raju,T.N;et.al Indian Exp Biol.2006, Sep.44(9);733-9)
  • 65. 7)MADHU • Contains almost all Micro-Nutrients. • Twenty fold Anti-oxidant capacity (water solution)than Vitamin C and Richest supplier of Anti-oxidant. • Clinical trial in Senile cataract with Installation of Honey in varying doses proved beneficial. (Golychev,V.N;Vestn Oftalmol,1990,Nov- Dec,106(6);59-62)
  • 66. 8)ZINC • Recently Zinc supplements is given to treat and prevent the ARMD. • Researchers have suggested that the Zinc and anti-oxidants delay the progression of ARMD and vision loss,possibly by preventing cellular damage in the retina.
  • 67. ANTI OXIDANTS AND EYE • ACC.to AOA, • The nutrition and vision project found that higher intake of vitamin C led to a reduced risk of cortical and nuclear cataract. • Results shoed that people who used vitamin C & E supplements for more than 10 years had decreased progression of nuclear cataract.
  • 68. ARMD: • Vitamin & Mineral formulation could be improved by adding lutein,zeaxanthin,or Omega-3 fatty acids and thereby reduced risk of ARMD.
  • 69. DISCUSSION • Acharya Charaka told, “चक्षुस्तेजोमयं तस्य विशेषात् श्लेष्मतो भयम ्” Chakshu is the chief site for Alochaka pitta but special protection Is required against he Kapha,because kapha dosha is opposite to Teja mahabhoota in reference to their Guna.
  • 70. • So chakshushya dravyas should be Kaphashamaka and pittavardhaka. • But pitta is Aadanakaraka and it will cause Chakshu indriya balahrasa. • So chakshushya dravyas should be having property of balancing all the 3 doshas especially keeping the pitta kapha saamya. i.e Kapha shamaka but without disturbing the pitta saamyata.
  • 71. The function of Chakshuindriya is done by Alochak pitta. So exposure to all Shitaviryadravyas and conditions should be avoided because they will vitiate the kapha.
  • 72. • Ushnaviryadravyas should be good for Chakshu. But this is not so simple as it looks. • Virtually, Pitta causes Indriyabalahrasa due to its aadanakaarak property while kapha is indriyabalavraddhikarak due to its visargakaraka quality.
  • 73. • Both these things seems contrary to each other. On the basis of above discussion it is clear that Chakshushyadravyas should be Pitta-Kaphashamak. • Tridoshashamakdravyas could be first choice, followed by Pitta-Kaphashamak then Kaphashamak and in last Pitta shamak
  • 74. • So these dravyas will do their action by Kaphashamana without disturbing the Pitta samyata as written in Charak Samhita- “Shleshmaharkarmamhitadrushteheprasadana m”.
  • 75. • As already mentioned by BhavaprakashaNighatu that being beneficial or being harmful depends upon the DRAVYA itself, not the properties • Ex: AMALAKI and LAKUCHA having same properties become tridosha shamaka and tridosha kopaka respectively.
  • 76. • Medicated grithas, bhasma of gold, copper, zinc and calcium etc. which are absorbed systemically are administered orally to fulfill the essentials of eye metabolism. • Herbo mineral compound preparations like Saptamritalauha, Netraarshini rasa, Mahatriphalagritha etc. are also advocated systemically
  • 77. • Eye care professionals have long encouraged patients to eat a healthy, well-balanced diet containing antioxidants, green leafy vegetables, Omega-3 fatty acids, and betacarotene. • Benefits of such diet helps to protect against diseases such as cancer and diabetes. • It's also important to avoid foods that have been proven to damage the eyes, such as saturated fats and aspartame.
  • 78. • Recent studies have examined the role of nutritional supplements in supporting eye health and treating eye disorders. • A combination of Vitamins A, C, and E, plus betacarotene supplements and zinc has been recommended by the National Eye Institute in the US as beneficial for patients with early signs of macular degeneration
  • 79. • Current studies show that macular degeneration can be slowed or reversed by supplementing the diet with a combination of xanthophylls: lutein, zeaxanthin, and meso-zeaxanthin. • In conjunction with antioxidant vitamin, zinc and Omega-3 supplementation, carotenoid supplements are now considered to be an essential part of a treatment regimen for MD.
  • 80. • Along with supplementation, lifestyle changes may be incorporated for those at risk of developing the advanced form of this disease.
  • 81. DRAVYAS PROBABLE MODE OF ACTION POPULAR MEDICATIONS DUGDHA VISUAL PHOTOTRANSDUCTION ,SCOTOPIC VISION BASE FOR ALL GHRITA PREPARATIONS & IN KRIYA KALPAS MADHU POTENT ANTIOXIDANT BASE FOR ALL THE ANJANAS SAINDAVA MAINTAINS THE NORMAL HYDRATION OF CORNEAL SURFACE KSHEERA SAINDAVA SEKA IS A POTENT SHOOLAHARA IN SHUKSHAKSHIPAKA GHRITA POTENT ANTI OXIDANT NEURO DEGENERATION BASE FOR ALL THE KRIYAKALPAS AS ITS SAMSKARASYA ANUVARTANAT PIPPALI BETA-SITOSTEROL ACTS AS VEHICLE FOR DRUG TO REACH ITS TARGET & POTENT ANTI BACTERIAL & ANTI USED IN MANY ANJANAS TO ACCELERATE THE ACTION OF DRUG KRIYA KALPA-CHAKSHUSHYA DRAVYAS
  • 82. DRAVYAS PROBABLE MODE OF ACTION POPULAR MEDICATIONS TRIPHALA POTENT ANTIOXIDANT BEST CHAKSHUSHYA-IN ALL KRIYAKALPAS SHIGRU ANTI OXIDANT, REJUVENATES CELLS OF LENS ARKA,SWARASA FOR ASCHYOTANA SHATAVARI ANTI OXIDANT, ANTI HAEMORRHAGIC, ANALGESIC USED AS KSHEERA PAKA & DIFFERENT KRIYA KALPAS RAKTACHANDANA POTENT HAEMOSTATIC LEPA & SEKA BHRINGARAJA ACTS BY SAPONIFICATION- IMMUNO MODULATORY, PREVENTS CELL DEATH, PROMOTES CELL GROWTH TAILA NASYA IN CATARACT,-TILA TAILADI NASYA -TIMIRA IS PROVED EFFECTIVE
  • 83. DRAVYAS PROBABLE MODE OF ACTION POPULAR MEDICATIONS PUNARNAVA ANTI SPASMODIC,ANALGE SIC, DIURETIC ACTS AS SHOTHAHARA WHEN USED IN DIFFERENT KRIYAKALPAS LODHRA ANTI INFLAMMATORY, ANTIBACTERIAL,FLAV ANOIDS RAKTA PRASADAKA GANA AS PER CHARAKA, INCORPORATED IN ALL KRIYAKALPAS JEEVANTI ANTI FUNGAL,ANTI OXIDANT, JEEVANIYA DRAVYA USED IN VARIOUS GHRITA, TAILA,PAYASA PREPARATIONS
  • 84. RASA DRAVYA PROBABLE MODE OF ACTION MEDICATIONS SWARNA NOOTROPHIC – STIMULATES THE NERVES BHASMA,POTTALI- ORALLY LOHA PHOTOTRANSDUCTION, PREVENTS OXIDATIVE STRESS-LENS SAPTAMRITA LOHA GANDHAKA MOTHER OF ALL ANTI OXIDANTS- SYNTHESIZES GLUTATHIONE,COMPONE NT OF CHOROID,LENS,TEAR FILM GANDHAKA RASAYANA PARADA YOGAVAHI-CAN BE CONSUMED THROUGHOUT ONE’S LIFE FOR LONGEVITY- ANANDAKANDA RASA SINDHURA- CHAKSHUSHYA TAMRA INCREASES UPTAKE OF IRON AND ZINC TAMRA GARBHA POTTALI RASAYANA
  • 85. CONCLUSION The various chakshusya dravyas mentioned in our classics are rich sources of Macro and micro nutrients like sorbitol, glucose, fructose, glycogen, mucoprotein , calcium, zinc, glutathione, vitamin A, vitamin E, Vitamin C, Vitamin K, Vitamin B1 B2 B6 B12 ,Vitamin D helps in maintaining normal function s,tuctural intrigity of the eye .
  • 86. Practicing / intake of chakshusya rasayana helps to prevent the eye disorders which can be prophylactic in many highly prevalent life style disorders in turn which causes pathological changes in eyes.
  • 87. SCOPE FOR FURTHER STUDY 1. Pharmacological and clinical work should be done to evaluate the chakshushya property of these drugs. 2. Phytochemical analysis of these dravyas should be done and responsible ingredients should be furher studied for chakshushya activity.