Anupana is a substance which is used in conjunction with the drug to enhance its effects. Mahadalu Anupana of Chandra Kalka is a type of Dalu Anupana which is quite popular among traditional medical fraternity. The exploratory study was directed towards the compilation of the pharmacological attributes of medicinal plants used in Mahadalu Anupana.

1. 1
Presented by:
Dr. R.L.D.S. Ranasinghe
MD Scholar, Dept of Kaya Cikitsa, IIM,
University of Colombo.
Co- author:
Prof E.R.H.S.S Ediriweera
Dept of Kaya Cikitsa , IIM,
University of Colombo.

2. 2
INTRODUCTION

3. ▀ The history of the Sri Lankan traditional medical
system is as ancient as the civilisation of the
Island.
▀ In this system drugs are mostly given orally with
some vehicles called Anupana.
▀ Mahadalu Anupana of Chandra Kalka is a type
of Dalu Anupana which is quite popular among
traditional medical fraternity.
3

4. 4
AIMS &
OBJECTIVES

5.  The present review is to study the
pharmacological attributes of medicinal
plants used in Mahadalu Anupana.
5

6. 6
MATERIALS &
METHODS

7.  Data were collected from
o Sri Lankan traditional and Authentic Ayurvedic
texts
o Traditional physicians
o Scientific journals
o Web sources
7

8. 8
RESULTS

9. Formula of Mahadalu Anupana
“ foys o fodvkA˝ksl˚ngqπhlskdrx ySkAkdrx o¿ o≠ fid|d≤
jkem, T<s| o≠l=mAmfïks l=Uqre o≤ o¿ tu weg ,iqkq Ωfhdod˚
fuuΩ Tiq ;ïndhqi˝uev ó meKs Ωi’ks˛.sf;,A fodveUqf,kA fhdo
;klsß pkAok˘l;l o˘.,.d˘o’mkA ieu f,v hdh uqod ”
9
Ref: Vatika Prakaranaya 1927 , 220, 221 pg

10. Ingredients of MahadaluAnupana
 Mahadalu anupana consists two main
components
1. Juice extracted from Tembuma (Steamed
medicine)
2. Prativapa
10

11. Sinhala
Name
Botanical name Family Part Used Propo
rtion
Dehi Citrus aurantifolia Rutaceae Tender Leaves 1 part
Dodam Citrus sinensis Rutaceae Tender Leaves 1 part
Nika Vitex negundo Fabaceae Tender Leaves 1 part
Elabatu Solanum surattense Solanaceae Tender Leaves 1 part
Yakinaran Atalantia ceylanica Rutaceae Tender Leaves 1 part
Heen naran Citrus reticulata Rutaceae Tender Leaves 1 part
Adatoda Adhatoda vasica Acanthaceae Tender Leaves 1 part
Ingredients of Tembuma (Juice extract)
of MahadaluAnupana
11

12. 12
Sinhala
Name
Botanical name Family Part Used Proporti
on
Olinda Abrus precatorius Fabaceae Tender Leaves 1 part
Kuppameni Acalypa indica Euphorbiaceae Tender Leaves 1 part
Kumburu Caesalpinia bonduc Fabaceae Tender Leaves 1 part
Kumburu Caesalpinia bonduc Fabaceae Seeds 1 part
Sudulunu Allium sativum Amaryllidaceae Bulb
Ingredients of Tembuma of MahadaluAnupana Cont..

13. Dehi Dodam Nika
YakinaranElabatu
Heen naran
Cont..

14. Adatoda Olinda
Kuppameni
Kumburu Seeds of Kumburu Sudulunu
14

15. Ingredients of Prativapa
of MahadaluAnupana
 Bee honey
 Sugar
 Ghee
 Juice of Citrus aurantium (Ambul Dodam )
 Breast Milk
 Santalum album (Suduhadun)
 Seeds of Strychnos potatorum (Ingini)
15

16. 16
Ingredients of Prativapa
of MahadaluAnupana
Sugar GheeBee honey
Breast Milk Suduhadun Seeds of Ingini
Ambul Dodam

17. Preparation of MahadaluAnupana
 Each ingredient enlisted are pounded separately and
mixed together .
 Boluses are prepared with this mixture.
 These boluses are heated using steam of water on low
fire.
 Then these are removed from steam when the aroma
started to emit.
 Finally juice is obtained by squeezing
out these boluses and Prativapa should
be added.
17

18. Indications of Mahadalu Anupana
“fiïmek ke.=fkA uqyqfkA odäh fkdnisk Wk
y;s weïu ;od
idroyiA ieg y;rlA ikAksh ÿgq l, oSmkA
fuTiq fhdod ”
Ref: Vatika Prakaranaya 1927 , 220, 221 pg
18

19. Ingredient Rasa Guna Veerya Vipaka Dosha Karma
Dehi Amla Laghu Anushna Madhura Tridosha
Samaka
Dodam Amla Guru,
Ushna
Ushna Amla Kapha, Vata
Samaka
Nika Tikta, Katu,
Kashaya
Laghu,
Ruksha
Ushna Katu Kapha, Vata
Samaka
Elabatu Madhura Laghu,
Ruksha,
Tikshna
Ushna Madhura Kapha, Vata
Samaka
Yakinaran Amla Laghu Ushna Kapha, Vata
Samaka
Heen naran Amla Laghu Ushna Kapha, Vata
Samaka
Properties of Mahadalu Anupana

20. Ingredient Rasa Guna Veerya Vipaka Dosha
Karma
Olinda Tikta,
Kashaya
Laghu, Ruksha,
Tikshna
Ushna Katu Kapha, Vata
Samaka
Kuppameni
Kumburu Katu, Tikta Laghu, Ruksha,
Tikshna
Ushna Katu Kapha, Vata
Samaka
Sudulunu Snigdha, Tikshna,
Picchila, guru, Sara
Ushna Katu Kapha, Vata
Samaka
Suduhandun Tikta,
Madhura
Laghu, Ruksha Sheeta Katu Kapha, Pitta
Samaka
Ingini Madhura,
Tikta,
Kashaya
Laghu,Vishada,
Vikashi
Sheeta Madhura Vata
Samaka
Properties of Mahadalu Anupana cont..
20

21. Properties of Mahadalu Anupana cont..
 Vedana Sthapana
 Ama Pachana
 Deepana
 Sroto shodhana
 Nadi Uttejaka
 Nadi Balakaraka
 Jvaraghna
 Mutrakaraka
21

22. Citrus sinensis (Dodam)
 gama limonene
 hesperidin
 iso hesperidin
 aurantiamarin
 auranetin
 tannin
 terpene
 geraniol
22
Phytochemicals of Ingredients of
Mahadalu Anupana
glucosides

23. Phytochemicals of Ingredients of Mahadalu
Anupana Cont..
Vitex negundo (Nika)
 alkaloid
 nishindine,
 an essential oil
 a resin
 flavanoides
 glucoside
 carotene
23

24. Phytochemicals of Ingredients of
Mahadalu Anupana Cont..
Adhatoda vasica (Adatoda)
 vasicine
 vasicinone
 vasicine acetate
 2-acetyl benzyl amine
24

25. Phytochemicals of Ingredients of Mahadalu
Anupana Cont..
Caesalpinia bonduc (Kumburu)
 fixed oil
 bitter principle- bonducin
 resinous acid
 phytosterolins
 saponin
 sucrose
 alkaloids
25

26. Phytochemicals of Ingredients of
Mahadalu Anupana Cont..
Abrus precatorius (Olinda)
 glycyrrhizin
 abrin
 isoflavanquinones
26

27. Bioactivities of Ingredients of Mahadalu
Anupana
 antioxidant (Adhatoda vasica, Citrus aurantium)
 anti-inflammatory (Adhatoda vasica, Abrus precatorius,
Caesalpinia bonduc)
 anti-cholinergic (Adhatoda vasica)
 antiplatelet (Abrus precatorius, Citrus aurantium)
 anti microbial (Caesalpinia bonduc)
 antineoplastic, anticarcinomic (Santalum album)
 diuretic (Strychnos potatorum
 hypoglycaemic ( Adhatoda vasica)
 antihyperlipidaemic (Caesalpinia bonduc)
27

28. 28
DISCUSSION

29. Effects of Mahadalu Anupana on vitiated
Dosha
 Tikta, Katu, Kashaya Rasa
 Laghu Guna, Ruksha Guna
 Ushna Veerya
 Katu Vipaka
29
Pacifies vitiated Kapha

30. Effects of Mahadalu Anupana on vitiated
Dosha Cont..
 Madhura Rasa
 Snigdha Guna
 Ushna Veerya
 Madhura Vipaka
30
Pacifies vitiated Vata

31. Effects of Mahadalu Anupana on vitiated
Dosha Cont..
 Madhura Rasa
 Snigdha Guna
 Sheeta veerya
 Madhura vipaka
31
Pacifies vitiated Pitta

32.  Performing Amapachana
 Eliminate Margavarodha (obstruction of
channels), occurred due to Kapha and Ama
 Relieve symptoms of provocated Vata in
Nadivaha and Vatavaha srotas
Eg: slurring of speech, mouth deviation,
fasciculation of tongue, and swallowing
difficulties
32
With these properties..

33. Action of Phytochemicals contain in ingredients
of MahadaluAnupana on Vata Vyadhi wsr to
Pakshavadha (Hemilpegia)
 Hesperidin a type of Glucoside prevents capillary
bleeding
 isoflavanquinones inhibits platelet aggregation
 So it would be beneficial in the management
of
- Haemorrhagic
- Thrombotic
- Embolic vascular lesions leading to Hemiplegia
(Pakshavadha)
33

34. Action of Phytochemicals Cont..
 Abrin and Vasicine are having anti-inflammatory
action; minimizes nerve damage and thereby improve
the outcome of patients
 Bonducin having antihyerlipidaemic action minimize the
formation of atheroma
 Citric acid, Santalol and Vasicine as anti oxidants
relieve oxidative stress which is leading to
atherosclerosis, stroke and high blood pressure
 Anti-oxidants able to neutralize the damaging effects of
free radicals
34

35. Cont..
 Sharkara (Sugar) is aphrodisiac, slightly unctuous, and
beneficial to those who are emaciated
 Ghee (Gruta) is promotive of memory, intelligence,
semen, vital essence
 Ghee increases the digestive fire (agni) and improves
absorption and assimilation
 As honey is composed of various Vitamins, Minerals, it
is the best of Vehicles. It is wholesome in small doses.
Its antioxidant constituents cleans up free radicals.
 Breast milk contains immunoglobulins and enhance
immune system
35

36. 36
CONCLUSION

37.  Due to its
 Ayurvedic pharmacodynamic properties
 Phytochemicals and
 Scientifically proven bioactivities
Mahadalu Anupana can be used effectively in
the management of Vata Vyadhi.
37

38. 38
REFERENCE

39. Reference
1. None] 1969, Ayurveda pharmacopeia Vol 1. Part 1, Colombo:
Department of Ayurveda.
2. [None] 1945, Ayurveda pharmacopeia Vol 1. Part 2, Colombo:
Department of Ayurveda.
3. [None] 1969, Ayurveda pharmacopeia Vol 1. Part 3, Colombo:
Department of Ayurveda.
4. Dassanayaka, M. D. 1981. A revised Handbook to the flora of
Ceylon. Vol 3. New Delhi: Oxford and IBH Publishing Co PVT Ltd.
6. Vatika Prakaranaya,
7. Jayaweera, D.M.A. 1981. Medicinal Plants (Indigenous & Exotic)
used in Ceylon. Part 3. Colombo: The National Science Council.
8. Wijesinghe , Y. 1994. Checklist of medicinal Plants of Sri Lanka.
Colombo: Sri Lanka Forest Department.
39

40. 9. [None] 2003, Aushadheeya shaka Samgrahaya, Vol 2 .
Olombo:Department of Ayurveda.
10. Bhattacharjee, S.K. 2000.Handbook of Aromatic Plants. Jaipur:
Pointer Publishers.
11. Dhananjaya, J. 2006. 2000.Handbook of Medicinal Herbs. India:
Deshpande Agrobis.
12. [None]1994. Osuturu wisituru, Vol 1, 2,3, 4.Colombo:Department of
Ayurveda.
13. International Journal of PharmTech Research CODEN (USA Debidas
Ghosh et al /Int.J. PharmTech Res 11/2002; 22:974-4304.
14. Bhagawan Dash, Kashyap, L. 1980. Materia Medica of Ayurveda,
New Delhi: Concept Publishers Company.
40

41. 15. Sharma, P.C, Yelne, M.B. 2000. Database on Medicinal Plants used in .
Ayurveda, New Delhi: Central Council for Research.
16. Nadkarani, A.K . 1982. Indian Materia Medica, Vol 1. India: Popular
Prakashtan.
15. Gurtner, GAIL H., et al. "Mechanism of hyperoxia-induced pulmonary
vascular paralysis: effect of antioxidant pretreatment." J. Appl. Physiol 59.3
(1985): 953-958.
16. G. H. Gurtner , J. R. Michael , I. S. Farrukh , A. M. Sciuto , N. F. Adkinson
17. Journal of Applied PhysiologyPublished 1 September 1985Vol. 59no.
953-958
18. Tandon, Vishal R., and R. K. Gupta. "Vitex negundo Linn (VN) leaf extract
as an adjuvant therapy to standard anti-inflammatory drugs." Indian Journal
of Medical Research 124.4
(2006): 447.
41

42. Thank you !
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