Why does (not) Kafka need fsync: Eliminating tail latency spikes caused by fsync
pH Determination Methods
1. Sorensen’s pH scale,
pH determination
by electrometric
and calorimetric
Presented by-
Prof. Mirza Salman Baig
Assistant Professor in Pharmaceutics
2. Dissociation constant (Kw)
• In any aqueous solution at a given temperature (Dissociation
constant = Kw)
• [H+] = [OH-] = 1.0 x 10-7 M
• [1.0 x 10-7][1.0 x 10-7] = 1.0 x 10-14
• Kw = [H+] [OH-]
• Acids
• [H+] increases and [OH-] decreases
• Bases
• [OH-] increases and [H+] decreases
3.
4. Sorensen’s pH scale
• pH = − log [H+]
• where, log is a base −10 logarithm and [H+] is the
concentration of hydrogen ions in moles per litre of solution.
• pOH = − log [OH-]
5. Sorensen’s pH scale
• Danish biochemist Soren Sorensen in 1909 developed the pH scale and
introduced pH definition as minus (−) logarithm of [H+] to the base 10.
• A pH of 7 is considered as “neutral”, because the concentration of
hydrogen ions is exactly equal to the concentration of hydroxide (OH−)
ions produced by dissociation of the water.
• The hydrogen ion concentration in pure water at room temperature is
about 1 × 10−7 M .
• Increasing the concentration of hydrogen ions above 1 × 10−7 M produces
a solution with a pH of less than 7, and the solution is considered as
“acidic”.
• On other hand decreasing the concentration of hydrogen ions below 1 ×
10−7 M produces a solution with a pH above 7, and the solution is
considered “alkaline” or “basic”.
8. Electrometric method
(glass electrode for pH)
• The pH of the sample is determined
electrometrically using either a glass
electrode in combination with a
reference potential or a combination
electrode
• pH is measured with a potentiometric
glass electrode.
• A pH electrode consists of two half-
cells; an indicating electrode and a
reference electrode.
9. Ph electrode/meter
• This creates a change in
electrical potential with respect
to the silver/silver chloride
reference
• This potential difference is
measured by a pH meter
(voltameter) and converted to
a pH output data
• A pH electrode contains a bulb at the end covered with a
thin glass membrane.
• This membrane becomes hydrated in the presence of
water.
• Hydrogen ions can enter the silicon-oxygen structure of
the glass and alter the charge.
10. Colorimetric method
• The basis of colorimetric analysis is the variation in the intensity of the color of a
solution with changes in ion concentration (or pH).
• The color may be due to an inherent property of the constituent itself (e.g. is
purple) or it may be due to the formation of a coloured compound as the result
of the addition of a suitable reagent which is called as an indicator.
• By comparing the intensity of the color of a solution of unknown pH with the
intensities of solutions of known pH, the pH of an unknown solution may be
determined.
• Certain organic substances change color in dilute solution when the hydrogen ion
concentration reaches a particular value.
• For example, phenolphthalein is a colorless substance in any aqueous solution
with a hydrogen ion concentration while it become pink at pH more than 7
(alkaline)