The circulatory system consists of the cardiovascular and lymphatic systems which are responsible for circulating blood, lymph, nutrients, hormones, oxygen and other gases to and from the cells of the body. The heart is a hollow muscular organ located in the center of the chest that acts as a pump to drive blood through the cardiovascular system, delivering oxygenated blood to tissues and deoxygenated blood to the lungs. It is divided into four chambers - two atria and two ventricles - which relax and contract to pump blood through the pulmonary and systemic circuits that make up the closed circulatory system. Key measurements of heart function include stroke volume, cardiac output, and ejection fraction.

1. Cardiac Anatomy & Physiology

2. Circulatory System
Cardiovascular and
lymphatic systems make up
the circulatory system a
vast network of organs and
vessels responsible for the
flow of:
The Cardiovascular system
• Blood
• Blood vessels
• Heart
The Lymphatic system
• Lymph
• Lymph nodes
• Lymph vessels
• Blood
• Nutrients
• Hormones
• Oxygen and other
gases
To and from the
Cells of the body
The heart is a hollow muscular organ made of specialised cells that
allow it to act as a pump within the circulatory system

3. The Heart
The Heart is:
• Located between the lungs in the centre and
to the left of the midline
• It is cone shaped and about the size of your
own clenched fist
• Can never stop pumping
Primary Function is to drive blood through the cardiovascular system delivering :
• Oxygenated blood to the tissues and organs of the body sufficient for their
metabolic needs
• Deoxygenated blood to the lungs for gaseous exchange

4. Cardiovascular system
The average human adult has 4-6 litres of blood
repeatedly cycled throughout the body in a
closed circulatory system.
It is called a closed system because the blood is
contained within the heart and blood vessels at
all time and blood always flows in a forward
direction.
Heart Ventricles
Arteries arterioles Capillaries
/ organs
Veins
Heart / atria

5. Structures
Human heart is divided into 4 chambers
• 2 Atria and 2 Ventricles – these are hollow
chambers which receive blood
• They are surrounded by myocardial cells
which are able to relax and contract
The cardiovascular system consists of circuits:
• Pulmonary circuit provides blood flow
between the heart and lungs
• Systemic circuit allows blood to flow to and
from the rest of the body
• Coronary circuit provides blood to the
heart
The heart valves ensure that blood flows in
one direction through the system

6. Coronary Circuit

7. Conduction system
There are 2 basic types of cardiac cell
(Myocytes)
• Myocardial cells
contractile
respond to an electrical impulse
and contract
• Specialised cells
the conduction system generates electrical
impulses and transmits them through the
myocardium
Site of electrical
impulse
generation
Rate of impulse
generation / min
SA node 60 - 100
AV node 40 - 60
Ventricles < 40

8. The Cardiac Cycle Contraction of a chamber = Systole
Relaxation of a chamber = Diastole
End systolic volume
End diastolic volume

9. End Systolic volume = amount
of blood In the ventricles at the
end of contraction / systole
End Diastolic Volume = amount
of blood in the ventricles at the
end of filling / diastole
The ventricles never completely empty
Introduction of Key Terms
Stroke Volume = The amount of blood pumped out of the ventricles per beat / contraction
(approx 70mls in a healthy adult male
EDV – ESV = SV

10. Introduction of Key Terms
Ejection fraction is a measurement of the percentage of blood leaving your
heart each time it contracts.
Usually measured with imaging e.g. ECHO / cardiac catheterisation / MRI.
Cardiac output and Ejection fraction are important indicators of how efficiently
the heart can meet the demands of the body
Cardiac Output (CO)
Amount of blood ejected by the heart per minute = cardiac output (CO)
In a healthy resting adult CO = approx 5-6 litres
CO = Heart Rate x Stroke volume

11. THANK YOU

12. Key points
The amount of blood pumped out of the ventricles per beat = stroke volume - approximately 70mls in
a healthy adult male. In this example: 125ml – 50 mls = 75mls
The output form the right and left side of the heart must always balance.
• THE AMOUNT OF BLOOD IN THE
VENTRICLES AT THE END OF FILLING
BEFORE SYSTOLE = END DIASTOLIC
VOLUME
• THE AMOUNT OF BLOOD IN THE VENTRICLES AT
THE END OF CONTRACTION OR SYSTOLE = END
SYSTOLIC VOLUME - THE VENTRICLES NEVER
COMPLETELEY EMPTY
End systolic volume
End diastolic volume
End diastolic volume = 125mls End systolic volume = 50mls
EDV – ESV = SV

13. Key points
Amount of blood ejected by the heart per minute = cardiac output (CO)
in a healthy resting adult CO = approx 5-6 litres
CO = Heart Rate x Stroke volume
E.g. C0 = 70bpm x 75mls = 5,250mls
Ejection fraction is a measurement of the percentage of blood leaving your
heart each time it contracts. Usually measured with imaging e.g. ECHO /
cardiac catheterisation / MRI.
Cardiac output and Ejection fraction are important indicators of how efficiently
the heart can meet the demands of the body