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Anticancer Properties of Roudra Rasa
1. By:
Dr.Lavanya.S.A
II yr PG Scholar
Dept of RS & BK
T.G.A.M.C
Bellary
Under the guidance of:
Dr.M.S.Doddamani
HOD & Professor
PG Dept of RS & BK
T.G.A.M.C
Bellary
2. Abuse of nature’s law upsets the human system and ends up in
disease like arbuda, granthi etc. It is again the nature , the foremost
physician who brings the cure. Ayurvedic system of medicine was well
founded on the basic principles of nature and its elements. No disease is
manifested without involvement of tridosha is the basic ideology of
ayurveda and one can control the vitiation of tridosha with the help of
herbal/ herbo-mineral compound.
Rasoushadhi’s are considered to be the most potent
formulations administered in smaller dosage forms. One such rasoushadhi
is ROUDRA RASA, which is mentioned in classics for the treatment of
Arbuda
8. It is a formulation told under Arbudadikara. There are 6 references
which are as follows available for this preparation.
Bhaishajya Ratnavali
Rasaratna samucchaya
Rasendra Chinatmani
Rasamruta
Bharata Bhaishajya Ratnakara
Basavarajiyam
10. METHOD OF PREPARATION
• Shuddha Parada and Shuddha Gandhaka is taken and kajjali is
prepared until the siddhi lakshanas are obtained.
11. Bhavana of kajjali is done with the following media for one time
each for 4 yama kala.
Nagavalli patra swarasa Meghanada Panchanga
Kwatha
Punarnava panchanga
kwatha
Gomutra Pippali Phala
Kashaya
12. Thereafter chakrikas are prepared and put inside sharava. After
sandhibandhana it is subjected for 1 laghu puta.
14. In majority of the references the ingredients are the same, only In
Basavarajiyam, Bala is told as an additional drug for bhavana, all
other ingredients are same.
In parishishta of Rasa yoga sagara, there is a preparation in the
name of Roudra rasa indicated for Sannipataja Jwara.
17. Properties
Rasa : Katu, Tikta
Guna : Laghu, Ruksha, Tikshna,
Vishada.
Veerya : Ushna
Vipaka : Katu
Karma : Shothahara, Kaphagna,
Poushtika, Jwaraghna etc..
Doshagnata : Kaphavatashamaka
Rogaghnata : Shotha, kasa, shwasa,
swarbheda, vibandha etc..
Actions Proved
Aqueous leaf extract exhibit
strong anti-proliferative activity
towards human naso-pharangeal
epidermoid carcinoma
Chlorogenic acid target and kills
myeloid and lymphoid cancer cells
Induce programmed cell death in
human cancer cells.
18. Rasa : Madhura,tikta,kashaya
Guna : Laghu,Rooksha
Veerya : Ushna
Vipaka : Madhura
Karma : Shothahara, Lekhana
Deepana, Anulomana,
Rasayana, Vishaghna,
Mootrajanana etc..
Doshagnata : Tridoshshamaka
Properties
Actions proved
Inhibits
Human NK Cell
cytotoxicity in
vitro
Enhances NK
cell Activity
Ethanolic extracts of roots
19. Rasa : Katu
Guna : Laghu,Sheeta,Rooksha
Veerya : Sheeta
Vipaka : Katu
Karma : Ruchya, Deepana,
Vishaharaka
Doshagnata : Kaphapittajit
Properties Actions proved
Antitumor
effects in EAC
Bearing mice
Increase
antibody
production
Ethanol
Extract
of leaves
20. Rasa : Katu
Guna : Laghu,Snigdha,tikshna
Veerya : Anushna sheeta
Vipaka : Madhura
Karma : Raktotkleshaka,
Deepana, Rasayana
Doshagnata : Kaphavatahara.
Properties Actions proved
Inhibit
growth of
tumor
induced DLA
Cells
Increase
lifespan of
mice bearing
ascites tumor
induced by
ELA
21. Properties Actions proved
Reduce
apoptosis in
lymphocytes
Repair the
damaged
DNA
Rasa : Katu, Tikta, Kashaya,
Guna : Ushna, Kshaara, Teekshna.
Veerya : Ushna
Vipaka : Katu
Doshagnata: Kaphavatahara
Rogaghnata: Shoola, Gulma, Aanaha,
Kandu, Akshiroga, Kilasa,
Mukharoga, Atisara
22. • Tridosha causes arbuda with
dominance of kapha and vata. Parada
is tridoshghna and gandhaka is kapha
vataghna.
• Katu tikta rasa of bhavana dravyas act
as rochana, deepana,pachana and
stimulates both Jatharagni and
Dhatvagni. Thus, acts as ama pachaka
and prevent the formation of ama.
• Srotas blocked by kapha and ama are
cleared up by the help of sroto
shodhana karma of the ingredients.
Actions proved
Cytotoxic against KB cells
Apoptotic action
23. • Ushna veerya of the drugs help in srotoshodhana by doing lekhana
karma.
• Vishaghna and krimighna action of gandhaka and rakta shodhana
karma of parada helps in purification of blood and work as antibiotic
and antiseptic.
• Due to laghu puta compound become sukshma, laghu and help in
reaching the site through its action at the main site of khavaigunya.
• The main lakshana of arbuda is shopha, Shopha mainly develops
because of kapha and medas. The bhavana dravyas are mainly
kaphahara and are of kashaya rasa which does lekhana karma.
• Madhu is given as anupana where in it is one of the best sleshmahara
dravya.
24. • Alpo hi matra vipulogunshcha……..
explains about the small quantity of the drug and great efficacy of rasa
dravyas.
• As the ingredients are easily available and the method of preparation is
easier, Roudra rasa is cost effective.
• Arbuda requires tridoshahara and rasayana chikitsa. Thus, roudra rasa
becomes the drug of choice in the treatment of cancer.
25. REFERNCES
1. Dr.Ambikadata Shastri,(1995) Sushruta samhita( Purvardha). Ayurveda Tatwa Snadipaika Hindi
vyakhya, 9th edition,Varanasi, Chaukambha Sanskrit Sansthan, Nidanasthana,P270 .
2. Shri Govindadas (2002), Bhaisajya Ratnavalli, Chapter 44, shloka no 59-60, edited by Kaviraj
Shri Ambikadatta shastri and by Shri Rajeswaradatta shastri (2002), Chaukambha Sanskrita
Samsthana, Varanasi, p 583.
3. Vaidya Pandit hariprapannafji (2005) Rasa Yoga Sagara, Chaukamba, chapter 3, shloka no 25-
26, Krishnadas academy, Varanasi, vol 2, p 619
4. Sri Gopala Krishna (2003) Rasendra Sara Sangraha, Chapter 3, shloka no 1-2, Dr. A.D. Satpute,
Chaukamba, Krishnadas academy, Varanasi, p 576.
5. Acharya Dhundhuk Nath (2006), Rasendra Chintamani, chapter 9, shloka no 1-2, Prof. Siddhi
nandan mishra, Chaukamba Orientalia, Varanasi, p 342.
6. Acharya Shalinath (2003), Rasa Manjari, chapter 6, shloka 320-321, Prof. Siddhi Nandan
Mishra, Chaukamba Orientalia, Varanasi, second edition, p 127.
26. 7. Shri Nagindas Chaganlal Shah (1999) Bharat Bhaisajya Ratnakara, Vaidya Gopinatha
bhishagratna, B.jain.publications, New Delhi, p 455 (6161).
8. Basavarajiyam (1999), Basavarajavirautam, Imprint Delhi, Chaukamba Samskritapratistha,
Varanasi, p 326.
9.Dhanwantari with shikki kandiyam (1979), commentary by kavungal neelkandapilla
chapter 80, reddiyar press,thiruvanthapuram, 4th edition, p 138.
10.Acharya Sri Madhava (2000), Ayurveda Prakasha chapter 2 shloka no 83, Shri Gulrajsharma
mishra and Pandit Shiva Sharma, Hindi commentary, Chaukambha bharat academy,
Varanasi, p 277.
11.Acharya Vagbhata (2003), RRS English translation chapter 1, shloka no 89, Dr. A.D. Satpute,
Chaukamba Sanskrit pratisthan, Delhi, 3rd edition, p 16.
12.Acharya Vagbhata (2003), RRS English translation, chapter 1, shloka no 34, Dr. A.D. Satpute,
Chaukamba Sanskrit ,pratisthan, Delhi, Chapter 1, 2nd edition p 8.
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Antitumour activity of the ethanol extract of Amaranthus spinosus leaves against EAC bearing
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