- HealthTech innovation is disrupting healthcare and its established players - Technology is driving a new paradigm to create better health care - Developing markets can leapfrog their healthcare infrastructure limitations - New opportunities are opening to shape the new paradigm

1. SMART HEALTH coLAB Ÿ Future of Healthcare
11th May 2015 Ÿ Singapore Ÿ The Propell Group
HEALTHCARE
The Future of
@enquirepropell
#HealthTech

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• HealthTech innovation is disrupting healthcare and its established players
• Technology is driving a new paradigm to create better health care
• Developing markets can leapfrog their healthcare infrastructure limitations
• New opportunities are opening to shape the new paradigm
Healthcare is changing dramatically

3. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
The convergence of the digital revolution with health:
ELEMENTS
Wireless devices
Hardware sensors
Sensing tech
Microprocessors
Integrated circuits
The Internet
Social Networking
Genomics
Personal genetics
What is HealthTech?
LEXICON
Wireless Health / mHealth
e-Patients / eHealth
Quantified Self / Self-tracking
Wearable Computing
Telehealth & Telemedicine
Personalized Medicine / QS
Health IT
Connected Health
Big Data / Health Data

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HealthTech frequently features in the media
Why Digital Health
Will Have Huge
Impact
March 3, 2014
By Todd Hixon
Digital Health has big buzz this year.
For example, it was a hot topic at both
the Consumer Electronics Show
(“CES”) and the more-serious JP
Morgan Healthcare Conference.
(“Digital Health” refers to products and
businesses that apply modern digital
technologies — the web, mobile, the
cloud, miniature sensors — to
healthcare.)
J.P. Morgan health
conference points toward
a hot year in digital
health
January 15, 2015
By Mark Sullivan
The J.P. Morgan event was a very different
scene, of course, and much smaller, but the
same energy for health tech was palpable
there, too. This conference usually focuses on
biotech and medical device companies. But
this year, the number of digital health
companies was decidedly larger and more
visible

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HealthTech Market Landscape

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1. Big Data and Impact on Healthcare
2. Advances in Wearable and Sensors
3. Business Models
4. Funding Trends
5. Asia HealthTech
Focus: HealthTech Innovation

7. “Healthcare isn’t a science problem,
it’s an information problem”
— Thomas Goetz —
Author of The Decision Tree: Taking
Control of Your Health in the New Era of
Personalized Medicine
Big Data
& HEALTHCARE

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HealthTech ecosystem: The new paradigm
Doctors
Efficient Healthcare
Better regulations
Insurance
Customize Packages
User specific rates
Enterprise
Faster discovery
Consumer insights
Individuals
Preventative Care
Personalized Care
Government
Efficient Infrastructure
Better Policy
Shared Information Cloud
Outbreak reports
Health tracking
Claims reporting
Insurance cover
Clinical trial data
Consumer reporting
Sensors and Trackers
Wellness reporting
Population Data
Public Awareness

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6 Ways Big Data is Changing Healthcare
Genomics & Beyond
Next generation sequencing, data
management & analysis
Data Analytics
Transforming Data: working with
and mixing data sets
Public Awareness
Planning and Preventing: Using data
to reduce and prevent disease
Support Providers
Clinical and Non-clinical Intelligence:
Combining a greater variety of data
Support Self-Care
Patient Focused: Increase variety
and frequency of data
Health Eco-system
Collaboration: Pooling data from many
sources for bigger & better results

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The Value of Big Data in Healthcare
$40-70 B
Right
Innovation
$300B
$450B
Healthcare Savings in the US
driven by Big Data
Right Value Right
Provider
Right Care Right Living
$50-100 B
$50-70 B
$90-110 B
$70-100 B • Targeted disease
prevention
• Data-enabled
adherence programs
• Alignment around proven pathways
• Coordinated care across providers
• Shifting volume to right care setting
• Reducing ER rates
• Payment innovation & alignment
• Provider-performance transparency
• Accelerating discovery in R&D
• Improving clinical trial operations
$300B to
$450B in
reduced
healthcare
spend

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Cloud-based, collaborative technology platform for
next generation sequencing and analysis tools
Genetic analysis applied to discover which
healthcare methods work, and for whom.
Tute Genomics is a cloud-based platform that can
rapidly analyze and annotate personal genomes
Personal DNA analysis and interpretation
service for individuals
Genomics & Beyond Next generation sequencing, data management & analysis

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Provide decision support tools to reduce cost,
improve quality of care and outcomes through
smart operational improvements in hospitals.
Free health records platform which aggregates
population health data across multiple sites
• Founded in the US – now launched in the UK
Cloud-based data platform for real-time insights and
intelligence – currently focused on oncology
• “ Software as a drug ”
Cloud-based platform focused on standardizing
health record management across providers e.g.
hospitals
Data Analytics: Transforming Data: working with and mixing data sets

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Big global data sets available to help guide policy
decisions and improve population health
Scans social media to forecast and track
outbreaks of disease
Identify counterfeit drugs and enable pharmaceutical
companies to track drug distribution
Real-time surveillance for emerging public health
threats by scanning informal sources
Public Awareness Planning and Preventing: Using data to reduce and prevent disease

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Diabetes management solution for patients, health
systems, and payer groups
Asia founded remote monitoring for physicians
to manage chronic patients
Collects data and organizes feedback to help
patients better manage asthma
Creates innovative and cost-effective online behavior-
change programs for chronic diseases
• CDC Recognised
Digital Therapeutics: Patient Focused: Increase variety and frequency of data

15. “Technology may replace up to
80% of what doctors do”
— Vinod Khosla —
Founder at Khosla Ventures
Wearable
SENSORS & DEVICES

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• Create a wealth of data in real time
• Measure physiological parameters easily
• Relate trends, behaviors and environments to health and wellness
• Analyze trends to understand the health ecosystem
Why do wearable and biosensors matter?

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Wearable ecosystem: Biosensing Wearables
Activity
Trackers
e.g. Fitbit, Misfit
Smart
Watches
e.g. Garmin, Apple
Smart
Clothing
e.g. Athos
Patches &
Tattoos
e.g. Zio, MC10
Ingestibles &
Smart Implants
e.g. Proteus
BioSensors
Devices that convert a
biological element into a
signal output
Wearables
Are on- or in-body devices
that enable user
experience

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Wearable and Sensors Market Landscape
WELLNESS DIAGNOSTIC CHRONIC MONITORING

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Garmin LumoFitbitWatch
APPLE WATCH
Smart-watch with activity
accelerometer and HR monitor
FITBIT SURGE
Smart-watch with activity
accelerometer and HR monitor
GARMIN 920XT
Triathlon training smart-watch with
GPS, HR monitor & activity
accelerometer
LUMOBACK
Posture monitor
Wellness Lifestyle monitor, intended to increase wellness

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Alivecor CueZioScout
ALIVECOR
Heart Monitor is a single-channel ECG
recorder that is portable and easy to use -
FDA approved!
SCANADU SCOUT
Sophisticated physical exam:
tracks & trends vitals such as to, HR, VO2,
ECG, BP
ZIO by iRythm
Micro sensor for long-term monitoring of
cardiac rhythms
CUE
Personal cartridge driven saliva analysis for
wellness management
Diagnostic, Chronic & Monitoring, Intended to aid medical systems and speed diagnosis

21. Business
MODELS
“Great products are becoming a
commodity. It's the combination between
great products and a great business model
that is going to keep you ahead of the
competition in the coming decade.”
— Alexander Osterwalder —
Business Model Generation, a global
bestseller on the topic of business model
innovation

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• Spending is inefficient or non-existent
• Policies are shifting in mature & developing countries
• Increasing focus on outcomes, not volumes
• New business models are forming to address changes
• 76% of Fortune 500 companies are now in healthcare
The healthcare business landscape is shifting

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Partnership with Genomics England to mine information
from a government project to decode the genomes of
100,000 patients from NHS patients with cancer and rare
diseases to discover personalised medicines
• Year-long trial announced March 2015
Has announced 12 undisclosed partnerships with
academia and corporate:
• Signed collaboration with Pfizer for the study of Crohn’s
disease
• Signed a $60M deal with Genentech (Roche) for the study of
Parkinson’s Disease
Pharmaco Genomics: The future of drug design
The Past: Molecular screening libraries used by most large drug companies and academic centers
The Future: Identifying the root cause of, or critical aberrant protein associated with a particular disease
and use this template to design the antibody or molecule to block it

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Clinical Data: Next generation clinical trials and RWE
Innovative tele-health solutions through interactive health technology
platform that consists of medical devices, application software, mobile
apps, cloud-based web applications focused on CV clinical trials
Open-source platform that empowers researchers to design and
administer app-based health research. Initial focus on breast cancer,
diabetes, Parkinson’s disease, CV and Asthma
Platform and algorithms allow to gather and show data for faster
clinical trials, and to support patients and doctor in the extreme
complexity of the real-world Neurology and Immunology treatments
• Post launch real-time patient data from extremely large numbers of patients
• Increasingly important data sets for market access and reimbursement
§ Velcade (J&J) for the treatment of Myeloma ($35,000 p.a.) was initially rejected by NICE
(UK). J&J agreed not charge any patient not deriving benefit. Velcade was approved

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Free cloud-based health
records platform which
aggregates population health
data across multiple sites
Supported by advertising
IN ASIA
Using mobile phones and
devices for innovative and
practical solutions for cost
effective healthcare services
Supported by Enterprise
IN ASIA
Employee engagement
platform that drives
productivity and manages cost
though employee wellness
Supported by Employers
IN ASIA
Electronic Health
Records (EHR)
mHealth
(Mobile Health)
Health Insurance /
Employee Wellness
Business Model Innovation: Increase relevance to the market

26. “Investments in digital health are having a
positive impact and the momentum is likely
to continue and cause changes throughout
the entire healthcare ecosystem. In
particular, the pharmaceutical industry is
poised to take advantage of digital and
mobile innovation allowing them to “go
beyond the pill”
— Jack Young —
Head – Qualcomm Life Fund
Funding
TRENDS

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• Key investment themes taking shape
• Venture capital funding doubles again
• Growing number of technology and strategic investors
• M&A deal flow growing
• Strong IPO trend
• 7,500+ DH startups across the globe
Significant activity in HealthTech funding

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Venture funding of HealthTech continues to outpace other sectors
Health Sector Funding Changes
Based on total funding from 2012 and 2013
2013 vs 2012 2014 vs 2013
All Sectors Health Tech Med DevicesBiotech
9%
61%
29%
127%
10%
29%
-17%
21%

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Venture funding of digital health: Key trends
Top Trends of Digital Health Funding
2011 to 2014
Ranking 2011 2012 2013 2014
1
Healthcare Consumer
Engagement
Healthcare Consumer
Engagement
EHR & Clinical Workflow
Analytics & Big Data
Data aggregation & analysis to support a wide range of healthcare use
cases
2 Analytics & Big Data EHR & Clinical Workflow Analytics & Big Data
Healthcare Consumer Engagement
Consumer tools for the purchasing of healthcare services or health
insurance
3 Digital Dx
Personal Health Tools &
Tracking
Digital Medical Devices Digital Medical Devices
Software / hardware designed to treat a specific disease or condition
4 EHR & Clinical Workflow Care Coordination
Population Health
Management
Telemedicine
Delivery of healthcare services through virtual channels
5 Post-acute Solutions Wearables & Biosensing Wearables & Biosensing
Personal Medicine
Software to support the practice of medicine customised to an individual’s
genetics
6 Hospital Administration Telemedicine
Healthcare Consumer
Engagement
Population Health Management
Platforms for managing population health under the shift to risk-based
payment models

30. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
Acquisitions: Is this the start of the HealthTech sector maturing?
95 M&A Deals in 2014 - $20B
ACQUIRER TARGET
Flatiron Health Altos Solutions
Teladoc AmeriDoc
Evidera Archimedes
Optum Audax
Roche Bina Technologies
MDLive Breakthrough
Hearst Health CareinSync
Cambia Health ClarusHealth
Merck eCardio
Google Lift Labs
UnitedHealth Group MedSynergies
WellTok MindBloom
HCA PatientKeeper
Facebook ProtoGeo (Moves)
AirStrip Wireless Sense4Baby
MyFitnessPal Sessions
WebMD TheraSim
Covidien Zephyr Technologies
Sector # of M&A deals
Health Tech
Med Device
Payer
Biopharma
Provider
Other
Healthcare
Tech
Other
47
8
6
6
4
4
7
13
ACQUIRER TARGET VALUE
BD CareFusion $12.2B
Cognizant TriZetto $2.7B
Cerner Siemens Health $1.3B
Optum Alere $600M
Aetna bswift $400M
Brighton Health Privia $400M
GE API Healthcare $340M
Emdeon Change Healthcare $185M
Medtronic Corventis $150M
Astra Zeneca Definiens $150M
Intel Basis $100M
Everyday Health Medico.com $100M
Millenium Labs RxAnte $70M
St Jude Medical CardioMEMS $60M
Care.com Citrus Lane $49M
Advisory Board Co. HealthPost $25M
Weight Watchers Wello $9M
Premier Meddius $8M
DISCLOSED UNDISCLOSED

31. “For all emerging markets, the
conditions are very challenging. But
where we see challenges, I see
opportunity. In fact: our challenges
are your opportunities ”
— Joko Widodo —
President, Indonesia
Asia
PARADOX

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Asia Paradoxes
Immature Healthcare Infrastructure
Health expenditure (%GDP) Health expenditure (per capita US$)
Nurses (per ‘000 population) Doctors (per’000 population)
3.5% 3.9% 4.6% 4.9%
9.0%
9.9%
11.0% 11.4%
16.9%
Kenya FranceBangla-
desh
India USJapan UKChina Ger-
many
19.50 44.10 44.50 164.50
3,445.90 3,590.80
4,524.10 4,973.10
7,830.10
FranceGer-
many
JapanUKChinaIndiaKenyaBangla-
desh
US
0.1
1.1 1.1 1.3
7.9 8.0 8.1
9.3
11.4
Ger-
many
JapanUSUKFranceIndiaKenyaChinaBangla-
desh
0.1
0.3
0.6
1.6
2.2 2.3
3.0
3.5
6.8
Ger-
many
FranceUSUKJapanChinaIndiaBangla-
desh
Kenya
Source: World Health Organisation, Espicom

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Asia Paradoxes
Large Unmet Medical Needs
Cardio Vascular Disease (Deaths per 100,000) Diabetes Disease (Deaths per 100,000)
Lung Cancer Disease (Death per 100,000) RTAs (Death per 100,000)
Indonesia AustraliaS.Korea China USIndia BangladeshSingapore France
Source: World Health Organisation,
34.7
79.7 82.4
150.8
165.8
203.7
29.2
60.3 68.8 80.5
UK Bangladesh FranceSingapore China USIndia IndonesiaS.Korea UK
10.8
13.4
23 23.8 23.8
29.5
5
8.1
9.9
15.2
Australia
S.Korea FranceIndia Bangladesh USSingapore ChinaIndonesia Australia
6.5
20.3 20.5
27.3 27.5
33.5
18.2
29.6 31
35.4
UK India FranceSingapore S.Korea USChina IndonesiaBangladesh UK
5.3
13.7
16.4
18.7
20.8
22.6
4.8
6.6 6.8
13.9
Australia

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Developing Markets Diamond
Deeper Market Relevance
From skimming to penetrating the market
Premium Market
Segment
Value Market
Segment
Underserved
Market Segment
56%
30%
13%
1%

35. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
• Lifestyle and wellness apps driven by growing middle class affluence
• Infrastructure management and modernisation
• Chronic disease management driven by growing health awareness
• Reverse innovation enabling better care at an affordable price point
• Growing demand for senior healthcare products and services
Asia: Key Drivers

36. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
HealthTech: Asia HealthTech Startup Landscape
Nascent But Thriving Ecosystem
Note: Not an exhaustive list!
Source: Health Startups Asia!
HealthTech Startup Categories
Big Data &
Analytics, 9
Consumer Health &
Wellness, 46
Genomics &
Precision
Medicine, 6
Navigating the
Healthcare System,
34
Patient
Engagement, 52
Practice
Engagement, 33
Sensors &
Diagnostics, 31
Telehealth &
Remote Monitoring,
9
HealthTech Startup Geographies
Australia, 29
Indonesia, 14
Singapore, 41
Malaysia, 6
Hong Kong,
14
India, 72
Philipines, 10
Vietnam, 5
China, 8
South Korea, 4
Thailand, 2
Japan, 14
Taiwan, 4

37. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
Venture funding of HealthTech: Asia key trends
Noteworthy Asia HealthTech Startups
Startup Funding ($M) Stage Principal Investors
Meet You (CH) 35 • Series C
• Matrix Partners
• K2 Ventures
Practo (INDIA) 30 • Series B • Sequoia Capital
PICOOC (CH) 25 • Series B
• Tencent
• Gobi Partners
HealthKart (INDIA) 20 • Series B
• Sequoia Capital
• Intel Capital
DocDoc (SG) 8.5 • Series A
• Jungle Ventures
• SparkLabs
Reka Health (SG) 4 • Series A • Tembusu Partners
DXY (CH) 2 • Seed & Pre A • DCM
Our Health Mate (SG) 1 • Seed & Pre A • LeoTech
Healint (SG) 1 • Seed & Pre A • Wavemaker
mClinica (SG) 1 • Seed & Pre A
• 500StartUps
• Kickstart Ventures

38. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
Asia Healthcare Accelerator Landscape
Most Asia accelerators have a broad sector focus
2015 will see the launch of 2 healthtech focused accelerators
• There are 100+ incubators &
accelerators across Asia –
virtually none are 100%
focused on healthtech
• Growing maturity of the
ecosystem vs. 115 healthtech
accelerators worldwide (87 in
the US)
• All players listed are potential
partners
• Putting Asia / Singapore on
the map
Incubator! Accelerator!
Focused!
Broad!
AHA!
(SG)!
Clearbridge
Accelerator
(SG)!
AIA !
(HK)!
MetLife
(SG)!
Independent!
Captive!
JFDI Asia
(SG)!
BioFactory
(SG)!
SPRING SSA
MedTech
(SG)1!
SparkLabs
(KR)!
rockstart!
(SG)!
Modern
Ageing !
(SG)!
Muru D!
(SG)!
Other Asia
Accelerators2!
Note 1: Zicom MedTacc and Med Tech Alliance, together with SPRING Singapore will co-invest S$60 million to develop promising medical technology ventures!
Note 2: A number of accelerators exist in Asia e.g. GSF India which operate on a similar model to JFDI Asia but have no deliberate focus on healthtech!
EVA !
(IN)!

39. • HealthTech is disrupting healthcare and its stakeholders
• Technology is driving a new paradigm to create better healthcare
• Asia healthcare will be able to leapfrog its infrastructure limitations
• New opportunities are opening to shape the new paradigm
• What healthtech solution could you hack?
Healthcare is changing dramatically

40. Julien
de SALABERRY
Experienced regional head and GM. 15+
years in healthcare with leading brands
including Eli Lilly, Boston Scientific,
Baxter, GSK, Merck & Co. Significant
Asia Pacific Experience.
The Propell Group is a boutique venture
investor and adviser firm focused on
early stage companies in healthcare
technology
aha! is a dedicated health-tech
accelerator focused on Asia 4 Asia
healthcare technology innovation
Co-Author of iDisrupted
Founder & CIO Ÿ The Propell Group
M: +65 9488 7334 Ÿ julien@propellgroup.biz
@enquirepropell

41. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
LOW COST PROSTHETICS
Researchers at the University of Toronto, in
collaboration with Autodesk Research and CBM
Canada, used 3D printing to quickly produce
cheap and easily customizable prosthetic sockets
for patients in the developing world
TAILOR MADE SENSORS
Researchers have used scans of animal hearts to
create printed models, and then added stretchy
electronics on top of those models. The material
can be wrapped around the real heart and
enhanced the electronics with multiple sensors
3D Printing: Next generation medical devices
BONE
Professor Susmita Bose of Washington State
University modified a 3D printer to bind chemicals
to a ceramic powder creating intricate ceramic
scaffolds that promote the growth of the bone in
any shape
HEART VALVES
Jonathan Butcher of Cornell University has printed
a heart valve that will soon be tested in sheep. He
used a combination of cells and biomaterials to
control the valve’s stiffness
MEDICAL EQUIPMENT
Dutch surgeons replaced the entire top of a 22
year–old woman’s skull with a customized printed
implant made from plastic
SKIN
James Yoo at the Wake Forest School of
Medicine in the US has developed a printer that
can print skin straight onto the wounds of burn
victims.

42. ©2015 by The Propell Group - All rights reserved. Proprietary and Confidential.
Micro sensor for long-term monitoring of cardiac
rhythms
Single-channel ECG recorder that is portable, easy
to use and low cost (FDA approved)
• Being rolled out across Apollo hospitals in India
Sophisticated physical exam:
tracks & trends vitals such as to, HR, VO2, ECG, BP
Flow monitor for safe and accurate infusion
• Y Combinator Accelerator graduate
Reverse Innovation: Clinical and Non-clinical Application