Deep vein thrombosis (DVT) occurs when a blood clot forms in one of the deep veins of the body, usually in the leg. It can be caused by factors that increase venous stasis, endothelial injury, or hypercoagulability. Common symptoms include leg swelling and pain. Diagnosis is usually made using ultrasound imaging of the veins. Treatment involves blood thinners to prevent further clotting and the risk of pulmonary embolism. Long term prevention focuses on compression stockings and avoiding prolonged sitting or immobility.

1. BY
HASHIM SYED ALI ABBAS HUSSAINI
PHARM D ( DOCTOR OF PHARMACY )
DEEP VEIN THROMBOSIS

2. What Is Deep Vein
Thrombosis ?

3. INTRODUCTION :
 Venous thromboembolism (VTE) A condition in which a blood clot
(thrombus) forms in a vein, which in some cases then breaks free and enters
the circulation as an embolus, finally lodging in and completely obstructing a
blood vessel, e.g., in lungs causing a PE (PULMONARY EMBOLISM)
 The most common type of venous thromboembolism is DEEP VEIN
THROMBOSIS, which occurs in veins deep within the muscles of the
leg,arm and pelvis.
 A superficial venous thrombosis (also called phlebitis or superficial
thrombophlebitis) is a blood clot that develops in a vein close to the surface of
the skin. These types of blood clots do not usually travel to the lungs unless
they move from the superficial system into the deep venous system first.

4. DEF:
 Deep vein thrombosis is the formation of a blood
clot in one of the deep veins of the body, usually in
the leg

5. Symptoms
Common symptoms include :
 swelling in your foot, ankle, or leg, usually on one side
 cramping pain in your affected leg that usually begins in your calf
 severe, unexplained pain in your foot and ankle
 An area of skin that feels warmer than the skin on the surrounding areas
 skin over the affected area turning pale or a reddish or bluish color

6. ETIOLOGY
Starts in
Lower
extremity calf
veins
progressing
proximally to
involve
Popliteal,
Femoral,
iliac system

7. Virchow triad
More than 100 years ago, Rudolf Virchow described a triad of factors of
-

8. Venous stasis
Endothelial
damage
Hypercoagula
ble state

9. Venous stasis
•prolonged bed rest (4 days or
more)
•A cast on the leg
•Limb paralysis from stroke
•spinal cord injury
•extended travel in a vehicle

10. Hypercoagulability
• Surgery and trauma - 40% of all thrombo embolic disease
• Malignancy
• increased estrogen
• Inherited disorders of coagulation -Deficiencies of protein-S,
protein-C, anti-thrombin III.
• Acquired disorders of coagulation- Nephrotic syndrome, Anti-
phospholipid antibodies
•

11. Endothelial Injury
Trauma
Surgery
 Invasive procedure
Iatrogenic causes –
central venous catheters
 Subclavian
 Internal jugular lines
These lines cause of upper extremity DVT.

12. Pathophysiology
Vessel trauma stimulates the clotting cascade.
Platelets aggregate at the site particularly when venous
stasis present
Platelets and fibrin form the initial clot
RBC are trapped in the fibrin meshwork

13. The thrombus propagates in the direction of the blood flow.
Inflammation is triggered, causing tenderness, swelling, and
erythema.
Pieces of thrombus may break loose and travel through circulation-
emboli.
Fibroblasts eventually invade the thrombus, scarring vein wall and
destroying valves. Patency may be restored valve damage is
permanent, affecting directional flow.

15. Presentation and Physical Examination
•Calf pain or tenderness, or both
•Swelling with pitting oedema
•Increased skin temperature and fever
•Superficial venous dilatation
•Cyanosis can occur with severe obstruction
•Less frequent manifestations of venous thrombosis include
 Phlegmasia alba dolens,
 Phlegmasia cerulea dolens, and
 Venous gangrene.
These are clinical spectrum of the same disorder.

16. P RO LO N G E D B E D REST, S U C H A S D U R I N G A LO N G H O S P I TA L STAY, O R PA RA LYS I S . W H EN YO U R L EG S
R E M A I N ST I LL FO R LO N G P E R I O D S , YO U R C A L F M U S C L ES D O N ' T CO N T R AC T TO H E L P B LO O D C I R C U L AT E ,
W H I C H C A N I N C R EA S E T H E R I S K O F B LO O D C LOT S .
I N J U RY O R S U RG E RY. I N J U RY TO YO U R V E I N S O R S U RG E RY C A N I N C R EA S E T H E R I S K O F B LO O D C LOT S .
B I RT H CO N T RO L P I L L S O R H O R M O N E R EP L AC E M E N T T HE RA PY. B I RT H C O N T RO L P I L L S ( O R A L
CO N T R AC E P T IV ES ) A N D H O R M O N E R E P LAC E M E N T T HE R A P Y B OT H C A N I N C R EA S E YO U R B LO O D ' S A B I L I T Y
TO C LOT.
B E I N G OV E RW E I G H T O R O B ES E . B E IN G OV E RW E I G H T I N C R EA S ES T H E P RES S U R E I N T HE V E I N S I N YO U R
P E LV I S A N D L EG S .
S M O K I N G . S M O K I N G A F F EC T S B LO O D C LOT T IN G A N D C I RC U L AT I O N , W H I C H C A N I N C R EA S E YO U R R I S K O F
DV T.
C A N C E R . S O M E FO R M S O F C A N C E R I N C R EA S E T H E A M O U N T O F S U B STA N C ES I N YO U R B LO O D T H AT C AU S E
YO U R B LO O D TO C LOT. S O M E FO R M S O F C A N C E R T R EAT M E N T A L S O I N C R EA S E T H E R I S K O F B LO O D C LOT S .
H EA RT FA I LU R E . P EO P L E W I T H H EA RT FA I LU R E H AV E A G R EAT E R R I S K O F DV T A N D P U L M O N A RY
E M B O L I S M . B EC AU S E P EO P L E W I T H H EA RT FA I LU R E A L R EA DY H AV E L I M I T E D H EA RT A N D LU N G F U N C T I O N ,
T H E SY M P TO M S C AU S E D BY E V E N A S M A L L P U L M O N A RY E M B O L I S M A R E M O R E N OT I C EA B L E .
I N F L A M M ATO RY B OW E L D I S EA S E . B OW EL D I S EA S ES , S U C H A S C RO H N ' S D I S EA S E O R U LC E R AT I V E CO L I T I S ,
I N C R EA S E T H E R I S K O F DV T.
A P E RS O N A L O R FA M I LY H I STO RY O F D E EP V E IN T HRO M B O S I S O R P U L M O N A RY E M B O L I S M ( P E ) . I F YO U
O R S O M EO N E I N YO U R FA M I LY H A S H A D DV T O R P E B E FO R E , YO U ' R E M O R E L I K E LY TO D E V E LO P DV T.
AG E . B E I N G OV E R AG E 6 0 I N C R EA S ES YO U R R I S K O F DV T, T H O U G H I T C A N O C C U R AT A N Y AG E .
S I T T I N G FO R LO N G P E R I O D S O F T I M E , S U C H A S W H E N D R I V I N G O R F LY I N G . W H E N YO U R L EG S R E M A I N
ST I L L FO R M A N Y H O U RS , YO U R C A L F M U S C L ES D O N ' T CO N T RAC T, W H I C H N O R M A L LY H E L P S B LO O D
C I RC U L AT E . B LO O D C LOTS C A N FO R M I N T H E C A LV ES O F YO U R L EG S I F YO U R C A L F M U S C L ES A RE N 'T
M OV I N G FO R LO N G P E R I O D S .
RISK FACTORS

17. Complications
Pulmonary embolism
A pulmonary embolism occurs when a blood vessel in your lung becomes blocked
by a blood clot (thrombus) that travels to your lungs from another part of your
body, usually your leg.
A pulmonary embolism can be fatal. So, it's important to be on the lookout for
signs and symptoms of a pulmonary embolism and seek medical attention if they
occur. Signs and symptoms of a pulmonary embolism include:
Unexplained sudden onset of shortness of breath
Chest pain or discomfort that worsens when you take a deep breath or when you
cough
Feeling lightheaded or dizzy, or fainting
Rapid pulse
Coughing up blood

18. Postphlebitic syndrome
A common complication that can occur after deep vein thrombosis
is a condition known as postphlebitic syndrome, also called
postthrombotic syndrome. This syndrome is used to describe a
collection of signs and symptoms, including:
Swelling of your legs (edema)
Leg pain
Skin discoloration
Skin sores
This syndrome is caused by damage to your veins from the blood
clot. This damage reduces blood flow in the affected areas. The
symptoms of postphlebitic syndrome may not occur until a few
years after the DVT.

19. Tests and diagnosis
•Ultrasound. A wand-like device (transducer) placed over the part of your body where there's a clot
sends sound waves into the area. As the sound waves travel through your tissue and reflect back, a
computer transforms the waves into a moving image on a video screen. A clot may be visible in the
image.
•Sometimes a series of ultrasounds are done over several days to determine whether a blood clot is
growing or to be sure a new one hasn't developed.
•Blood test. Almost all people who develop severe deep vein thrombosis have an elevated blood
level of a clot-dissolving substance called D dimer.
•Venography. A dye (contrast agent) is injected into a large vein in your foot or ankle. An X-ray
procedure creates an image of the veins in your legs and feet, to look for clots. However, less invasive
methods of diagnosis, such as ultrasound, can usually confirm the diagnosis.
•CT or MRI scans. Both computerized tomography (CT) scan and magnetic resonance imaging
(MRI) can provide visual images of your veins and may show if you have a clot. Sometimes a clot is
found when these scans are performed for other reasons.

20. Treatments and drugs
•Deep vein thrombosis treatment is aimed at preventing the clot from getting any bigger, as well as
preventing the clot from breaking loose and causing a pulmonary embolism. After that, the goal becomes
reducing your chances of deep vein thrombosis happening again.
•Deep vein thrombosis treatment options include:
•Blood thinners. Medications used to treat deep vein thrombosis include the use of anticoagulants, also
sometimes called blood thinners, whenever possible. These are drugs that decrease your blood's ability to
clot. While they don't break up existing blood clots, they can prevent clots from getting bigger or reduce your
risk of developing additional clots.
•Usually, you'll first be given a shot or infusion of the blood thinner heparin for a few days. After starting
heparin injections, your treatment may be followed by another injectable blood thinner, such as enoxaparin
(Lovenox), dalteparin (Fragmin) or fondaparinux (Arixtra). Other blood thinners can be given in pill form,
such as warfarin (Coumadin, Jantoven) or rivaroxaban (Xarelto). Newer blood thinners also may offer
additional options in the near future.
•You may need to take blood thinners for three months or longer. If you're prescribed any of these blood
thinners, it's important to take your medication exactly as your doctor instructs. Blood-thinning medications
can have serious side effects if you take too much or too little.
•You may need periodic blood tests to check how long it takes your blood to clot. Pregnant women shouldn't
take certain blood-thinning medications.

21. Clotbusters. If you have a more serious type of deep vein thrombosis or pulmonary
embolism, or if other medications aren't working, your doctor may prescribe different
medications.
One group of medications is known as thrombolytics. These drugs, called tissue plasminogen
activators (TPA), are given through an IV line to break up blood clots or may be given
through a catheter placed directly into the clot. These drugs can cause serious bleeding and
are generally used only in life-threatening situations. For these reasons, thrombolytic
medications are only given in an intensive care ward of a hospital.
Filters. If you can't take medicines to thin your blood, a filter may be inserted into a large
vein — the vena cava — in your abdomen. A vena cava filter prevents clots that break loose
from lodging in your lungs.
Compression stockings. These help prevent swelling associated with deep vein
thrombosis. These stockings are worn on your legs from your feet to about the level of your
knees.
This pressure helps reduce the chances that your blood will pool and clot. You should wear
these stockings during the day for at least two to three years if possible. Compression
stockings can help prevent postphlebitic syndrome.

22. Lifestyle and home remedies
Once you receive treatment for deep vein thrombosis you need to watch your diet and look for signs of excessive
bleeding, as well as take steps to help prevent another DVT. Some things you can do include:
Check in with your doctor regularly to see if your medication or treatments need to be modified. If you're taking
warfarin (Coumadin, Jantoven), you'll need a blood test to see how well your blood is clotting.
Take your blood thinners as directed. If you've had DVT, you'll be on blood thinners for at least three to six
months.
Watch how much vitamin K you're eating if you are taking warfarin. Vitamin K can affect how warfarin works.
Green leafy vegetables are high in vitamin K. Check with your doctor or a dietitian about your diet if you're taking
warfarin.
Be on the lookout for excessive bleeding, which can be a side effect of taking medications such as blood
thinners. Talk to your doctor about activities that could cause you to bruise or get cut, as even a minor injury could
become serious if you're taking blood thinners.
Move. If you've been on bed rest, because of surgery or other factors, the sooner you get moving, the less likely blood
clots will develop.
Wear compression stockings to help prevent blood clots in the legs if your doctor recommends them.

23. Prevention
To prevent deep vein thrombosis, some common preventive measures include the following:
Take any prescribed medications as directed. If you're having surgery, such as orthopedic
surgery, you'll probably be given blood thinners while you're in the hospital. Your doctor may also
prescribe aspirin or other medications that help prevent clots to be taken for a while after surgery.
Avoid sitting still. If you've had surgery or have been on bed rest for other reasons, try to get
moving as soon as possible. If you're sitting for a while, try not to cross your legs because this can
limit blood flow. If you're traveling a long distance by car, stop every hour or so and walk around.
If you're on a plane, try to stand or walk occasionally. If you can't do that, at least try to exercise
your lower legs. Try raising and lowering your heels while keeping your toes on the floor, then
raising your toes while your heels are on the floor.
Make lifestyle changes. Lose weight and quit smoking. Obesity and smoking increase your risk
of deep vein thrombosis.
Get regular exercise. Exercise lowers your risk of blood clots, which is especially important for
people who have to sit a lot or travel frequently.