This webinar discussed clinical trials for colorectal cancer. It addressed myths about clinical trials and provided resources for finding open trials. Presenters included physicians, researchers, and a three-time colon cancer survivor who works as a clinical trials curator. The curator discussed her experience being trained to evaluate trials for inclusion on the Fight CRC Clinical Trial Finder website. Challenges to enrollment were covered, and advice was given by a physician on searching for and participating in a clinical trial. The webinar concluded with a question and answer session.
2. TODAY’S WEBINAR
SPEAKER(S)
Dr. Angela Nicholas, Family Practice Physician, Caregiver
Dr. Chris Heery, Chief Medical Officer for Precision BioSciences
Wenora Johnson, Survivor, Fight CRC Research Advocate
Reese Garcia, Fight CRC Research Advocacy Manager
WEBINAR ARCHIVE
FightCRC.org/webinar
QUESTIONS
Ask a question in the panel on the RIGHT SIDE of your screen
TWEET ALONG
Follow along via Twitter – use the hashtag #CRCWebinar
POST WEBINAR
Expect an email with links to the material & a survey. If you fill it out,
we’ll send you a Fight CRC bracelet.
4. FIGHTCOLORECTALCANCERDISCLAIMER
The information and services provided
by Fight Colorectal Cancer are for
general informational purposes only.
The information and services are not
intended to be substitutes for
professional medical advice,
diagnoses or treatment.
If you are ill, or suspect that you are ill,
see a doctor immediately. In an
emergency, call 911 or go to the
nearest emergency room.
Fight Colorectal Cancer never
recommends or endorses any specific
physicians, products or treatments for
any condition.
5. Today’sPresenters
Dr. Chris Heery is the Chief Medical Officer for Precision
BioSciences. Prior to joining Precision BioSciences, he served as
Chief Medical Officer of Bavarian Nordic. Before that, Dr. Heery
served as the Director of the Clinical Trials Group at the Laboratory
of Tumor Immunology and Biology at the National Cancer Institute
(NCI) in Bethesda, Maryland. During his 7 years at the NCI, his
clinical research focused on the use of novel agents capable of
inducing the immune system to recognize and kill cancer cells. He
is a graduate of Duke University and received his MD from East
Carolina University Brody School of Medicine.
Dr. Angela M. Nicholas, M.D., is a Board Certified Family Practice
Physician. Dr. Nicholas is also the Medical and Administrative
Director of Einstein Physicians Montgomery and a member of
Einstein Physicians Montgomery Management Committee and the
Quality and Compliance Committee. She has a particular interest
in women’s health and prevention of illness through exercise and
diet. Dr. Nicholas served as a caregiver to her late husband, John
MacCleod.
6. Today’sPresenters Wenora Y. Johnson is a three-time cancer survivor, Volunteer Fight CRC
Research/Patient Advocate, Caregiver/Provider, and U.S. Navy Veteran,
serving 8 years as a Reservist. Wenora began working closely with the
organization Fight Colorectal Cancer (FightCRC) as a Research Advocate after
her diagnosis of stage 3b colon cancer in 2011. She was also a
caregiver/provider for her elderly mother and younger brother, who is also a
cancer survivor. As a volunteer with Fight CRC, she shares her understanding
of policy, research, patient engagement and clinical trials with the healthcare
community. Wenora is fully engaged as an advocate, bringing awareness of
healthcare disparities to Capitol Hill multiple times a year.
Reese joined Fight CRC in August of 2017 as the Research Advocacy Manager.
She is passionate about working with cancer survivors and those that
empower survivors. She currently oversees the Research Advocacy Training
and Support (RATS) program and helps plan and coordinate colorectal cancer
research related campaigns nationwide. Reese earned her Master of Public
Health at the Colorado School of Public Health at the University of Colorado
Denver and has spent a majority of her time working with disadvantaged
global and rural communities to overcome health disparities.
7. Insight from a Caregiver and Physician:
Challenges, Successes, and Experience
Searching for Trials
Dr. Angela Nicholas
9. • Tool that help patients with “MSS” colorectal cancer get a
potential list of clinical trials to discuss with their medical
teams
Brainchild of Dr. Tom Marsilje, a stage IV survivor and
scientist
Tom’s criteria for trials added to the tool:
1) Trials with a “reduced” chance of potential failure
2) Trials with the biggest “potential” long-term benefit
http://trialfinder.fightcrc.org/
Fight CRC Clinical Trial Finder
10. Curation Process and Curators
• Fight CRC currently has 6 research advocates curating the tool as level 1 curators
• Two level 2 curators
• Every day, curators sort through list of trials based on logic flow developed by Dr. Tom
• Working closely with experts in the field to keep curation list up to-date
• Only Patient Curated Clinical Trial Finder
11. Wenora Johnson
Fight CRC
Research Advocate with RATS
Clinical Trials Curator
A little bit about me:
Diagnosed with Colon Cancer in 2011 at the age of
45
NED in 2015 and had genetic testing in 2016
confirming Lynch Syndrome.
2016 Endometrial Cancer
2017 Basel Cell Carcinoma
2019 NED but due to Lynch Syndrome diagnose always
following up with physicians every 6 months
12. My involvement with Fight CRC
• 2014 Submitted my Cancer Story to Fight CRC
and became a Volunteer Advocate
• 2015 Applied to become a Research Advocate
Training Support (RATS) volunteer
• 2016 Attended my first “Call on Congress”
Event with Fight CRC
• 2017 Clinical Trials Curator
Because Fight CRC provided me with advocacy,
policy and clinical trials training, I’m now
actively involved with:
• CAP Patient Advocate Board Member
• NCCS CPAT Member
• PCORI Ambassador
• PCORI Clinical Trials Review Panel
• DoD Consumer Reviewer for Cancer Research
• CMC TEP Panel Member
• AACR Scientist Survivor Program
• FORCE Volunteer Advocate
13. Clinical Trials Curator
• Began training to curate
Clinical Trial in December of
2017.
• Monthly meetings until June of
2018 before allowed to curate
with a trained partner.
• Teams are put on the schedule
to curate every 6-8 weeks.
• Flow chart also created to help
assist with deciding which trials
to keep or triage.
• Provided with Clinical Trials tips
at every monthly meeting.
• Any questions encountered while
curating, were immediately
addressed by Reese or Mia.
• Teams were encouraged to work
together in the beginning and
after a level of comfort allowed
to alternate with partner to
eventually curating alone.
• Use Google Classroom to post
articles of interest on certain
clinical trials and to keep track
of questions and time spent
curating.
• Submitting Clinical Trials of the
Month
14. Clinical Trials Curator
What I learned:
• Stronger understanding of MMR/MSI
• Immunotherapy Treatment – immune
checkpoint inhibitors
• Targeted Therapies
• Vaccines to boost the immune
system
• Solid tumors
• Because of clinical trials new drugs
such as:
• Avastin
• Keytruda
• Opdivo
• There are over 300,000 clinical trial
studies currently on the Clinicaltrails.gov
website
• 10 new drugs were approved by the FDA
between February and May 2019 for
various diseases – underscoring the
importance of research and new
therapies for colon cancer.
• 95% of people who have participated in a
clinical trial say that they would be
willing to participate in another.
• While smoking may contribute to cancer
deaths, the biggest contributor is not
living a healthier lifestyle!
16. Advice for searching and enrolling in a
Clinical Trial
Dr. Angela Nicholas
Wenora Johnson
17. Q
&
A
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