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Nanofibers for Biomedical and
Healthcare Applications
A Techno-Commercial Report

Molecular Filtration

Tissue Engineering

Medical Implants

Drug delivery

Medical Textiles

Wound Healing

Biosensors

Cosmetics

Centre for Knowledge Management of Nanoscience & Technology
(A Project of ARCI, Department of Science & Technology, Govt. of India)
12-5-32/8, Vijayapuri Colony, Tarnaka, Secunderabad-500 017, A.P India
.,
Telephone: +91 40 2700 7032, 2700 0251, Telefax: +91 40 2700 7031
E-mail: info@ckmnt.com, Website: www.ckmnt.com
December 2013
A comprehensive techno-commercial report overviewing the potential of nanofibers in biomedical
and healthcare applications with a focus on materials, fabrication techniques, latest technological
developments/trends, applications and products, as well as a detailed global market scenario.

Report Highlights
•• A comprehensive review of technical aspects related to types of materials, fabrication
techniques and available commercial technologies for the fabrication of nanofibers
•• Overview of potential biomedical applications of nanofibers and various nanofiber-based
commercial products in the biomedical and healthcare sector
•• A detailed market overview by material type, biomedical applications and geographical
regions
•• An in-depth literature and patent analyses to assess the worldwide scientific and technological
advances made in the application areas of nanofibers for biomedical and healthcare sector
•• Profiles of leading global players involved in the development and commercialization of
nanofibers as well as nanofiber-based application developers in biomedical and healthcare
sector

Who should buy this Report
•• Nanofiber manufacturers and suppliers
•• Nanofiber-based biomedical application developers and product manufacturers
•• Nanofiber process equipment manufacturers and suppliers
•• Corporate strategists, policy advisors and government agencies
•• R&D organizations and universities working in the area of nanofibers
•• Consultants and analysts
•• Investors and funding agencies

80 Companies Profiled Including
•• 3-D Matrix Medical Technology
•• Boston Scientific Corporation
•• Clearbridge Nanomedics Pte Ltd.
•• Covidian plc
•• Donaldson Company, Inc.
•• DuPont de Nemours and Company
•• Early Warning Inc.
•• Elmarco s.r.o.
•• FibeRio Technology Corporation
•• Finetex EnE, Inc
•• Fresenius Medical Care AG & Co. KGaA
•• Hollingsworth & Vose Company
•• Irema-Filter Gmbh
•• Japan Vilene Company, Ltd.
•• Johns Manville Corporation
•• Marine Polymer Technologies, Inc.

•• Metpro Technologies LLC
•• Mitsubishi Rayon Co., Ltd.
•• Nano Technics Co. Ltd.
•• Nanofiber Solutions
•• Nanosys Inc.
•• NANOVAL GmbH & Co. KG
•• Neotherix Ltd.
•• Nicast Ltd.
•• NOLabs AB
•• Organogenesis Inc.
•• PARDAM s.r.o
•• Polyremedy, Inc.
•• Pyrograf Products, Inc
•• Smith & Nephew plc
Table of Contents*
Executive Summary

4.2. Global Overview of Patents

1. Overview

4.2.1. Year Wise Trend Analysis of
Patenting Activity

1.1. Key Takeaways
1.2. Study Goals and Objectives
1.3. Research Methodology
1.4. Introduction to Nanofibers
1.4.1. Theoretical Background and
History
1.4.2. Key Features

4.2.2. Geographic and Priority Country
Wise Distribution
4.2.3. Top Assignees and Research
Focus Areas
4.2.4. Technology Focus
4.2.5. Corporate Patents Landscape
4.2.6. Key Patents

1.4.3. Applications
1.4.4. Industry and Market Overview
2. Scientific and Technological Aspects

5. Market Overview
5.1. Global Nanofibers Market for Biomedical
Applications

2.1. Materials Used for Nanofiber Fabrication

5.1.1. Demand and Supply

2.2. Techniques for Nanofiber Fabrication

5.1.2. Market by Materials Type

2.3. Processing of Nanofibers
2.4. Properties and Characterization of
Nanofibers
2.5. Technological Issues and Critical
Challenges
3. Biomedical and Healthcare Applications
3.1. Tissue Engineering
3.2. Wound Dressing /Healing
3.3. Drug Delivery Systems
3.4. Biosensors
3.5. Medical Devices/Implants
3.6. Medical Filtration Media
3.7. Cosmetics/ Personal Care
3.8. Nanofiber-based Commercial Products
4. Literature and Patent Analysis
4.1. Global Overview of Literature
4.1.1. Year Wise Publication Trends
4.1.2. Geographic Distribution
4.1.3. Publication Trend by Institutes &
Organizations
4.1.4. Contribution of Funding Agencies

5.2. Global Market by Biomedical
Applications
5.3. Global Nanofiber-enabled Biomedical
Market: Trends & Forecasts
5.3.1. Trends and Forecast
5.3.2. Trends and Forecast by
Biomedical Applications
5.4. Market Metrics
5.4.1. Porter’s Five Forces Analysis
5.4.2. Key drivers
5.4.3. Challenges
5.4.4. Opportunities
6. Competitive Landscape
6.1. New Product Developments
6.2. Agreements/Partnerships
6.3. Mergers and Acquisitions
7. Technologies Available for Licensing
8. Safety, Health and Environmental
Aspects
9. Regulations
10. Company Profiles

4.1.5. The Top 10 Highly Cited Research
Publications
4.1.6. Technical Analysis
*A sample of table of contents is given here
Executive Summary
Nanofibers Markets for Biomedical
Applications (in US$ million)

180
Nanofibers are an important and versatile class of
155.2
Five year Forecast
160
Five year Trend
one-dimensional nanomaterials that has attracted
(2013-2018)
(2007-2012)
140
increasing attention in the recent years. Nanofibers
113.3
120
)
especially made of biocompatible or biodegradable
100
.8%
6
82.7
(3
)
80
materials show great potential in biomedical and
GR
.5%
60.4
29
CA
(
60
healthcare sector due to their unique combination of
GR
44.1
CA
40
32.4
properties and intrinsic functionalities. High surface
17.8 24
20 6.6 8.2 10.4 13.4
area and porosity associated with nanofibers that
0
2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018
enhance adhesion of cells as well as various proteins
Year
and drug molecules are the key attributes, which
Five-year trends (2007-12) and forecasts (2013-18) of
make them superior to their micro and macro
nanofiber-enabled biomedical markets
counterparts composed of same materials.
This techno-commercial report discusses various applications of nanofibers in biomedical and healthcare
sector and provide them as advanced and potential solutions to the current challenges facing in this
rapidly expanding field. Industrial developments in manufacturing technology by employing various
proprietary processes based on electrospinning, solution & melt spinning and melt-blowing methods
have provided the much-needed momentum for realizing the commercial potential of nanofibers. Major
class of nanofibers used in various biomedical and healthcare applications are prepared from various
natural and synthetic polymers as well as from their composites with inorganic materials. Ceramic/
inorganic nanofibers and carbon nanofibers are also increasingly being used. Important biomedical
applications of nanofibers include filtration, medical textiles, wound healing, tissue engineering &
regeneration, biosensors and drug delivery.
This report analyses the nanofiber-enabled global biomedical market size in terms of material types,
biomedical applications and geographical regions. The report also discusses the key drivers, challenges
and opportunities for nanofibers in biomedical industry. Nanofiber industry is a global enterprise serving
niche market applications. The global demand of nanofibers in biomedical industry reached 30 metric
tons per annum in 2012. The global nanofiber-enabled biomedical market was valued at US$ 24 million
in 2012 and is further expected to grow at a Compound Annual Growth Rate (CAGR) of 36.8% during
2013-2018 to reach US$ 155.2 million by 2018. North America tops the list with a share of 50% in global
nanofiber-enabled biomedical markets, followed by Europe (37%), Asia-Pacific (12%) and RoW (1%).
Polymer nanofibers constitute the largest share of total nanofibers market in terms of materials. The
largest market share of nanofibers for biomedical applications is accounted for by filtration followed by
medical textiles, wound healing, tissue engineering etc. In the next five years, the consumption is
expected to post a considerable growth due to their unique combination of desirable properties, high
compatibility with nonwovens and ready availability of biodegradable nanofibers over the conventional
fibers. The US is the world leader in research and development in this area followed by Asian countries
like China and South Korea.
Global nanofiber industry landscape is dotted with numerous start-up companies as well as large
corporations. Most of the nanofiber manufacturers are large corporations and some of them have captive
uses for their production. Majority of the application developers are however small start-up companies,
which either are spin-offs from universities or armed with technologies licensed from universities. This
market is still in very nascent stage and therefore ample opportunities exist for the entry of new players
across the globe.

How to Order?
Please make your payment by cheque/DD in favour of “ARCI-Nanotech Insights” payable at Hyderabad or
ECS/TRGS or Cridit/Debit cards.
Cost (print + soft copy): ` 60,000*, Only soft copy: ` 50,000*,
*Add bank charges of ` 90/- for outstation cheques within India

Send your order to: H. Purushotham, Scientist-G & Head

Centre for Knowledge Management of Nanoscience & Technology (CKMNT)
(A Project of ARCI, Department of Science & Technology, Govt. of India)

12-5-32/8, Vijayapuri Colony, Tarnaka, Secunderabad-500 017, India, Telephone: +91 40 2700 7032, +91 40 2700 0251,
Telefax: +91 40 2700 7031, E-mail: info@ckmnt.com, Website: www.ckmnt.com

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Nanofibers for Biomedical and Healthcare applications: A Techno-commercial Report

  • 1. Nanofibers for Biomedical and Healthcare Applications A Techno-Commercial Report Molecular Filtration Tissue Engineering Medical Implants Drug delivery Medical Textiles Wound Healing Biosensors Cosmetics Centre for Knowledge Management of Nanoscience & Technology (A Project of ARCI, Department of Science & Technology, Govt. of India) 12-5-32/8, Vijayapuri Colony, Tarnaka, Secunderabad-500 017, A.P India ., Telephone: +91 40 2700 7032, 2700 0251, Telefax: +91 40 2700 7031 E-mail: info@ckmnt.com, Website: www.ckmnt.com December 2013
  • 2. A comprehensive techno-commercial report overviewing the potential of nanofibers in biomedical and healthcare applications with a focus on materials, fabrication techniques, latest technological developments/trends, applications and products, as well as a detailed global market scenario. Report Highlights •• A comprehensive review of technical aspects related to types of materials, fabrication techniques and available commercial technologies for the fabrication of nanofibers •• Overview of potential biomedical applications of nanofibers and various nanofiber-based commercial products in the biomedical and healthcare sector •• A detailed market overview by material type, biomedical applications and geographical regions •• An in-depth literature and patent analyses to assess the worldwide scientific and technological advances made in the application areas of nanofibers for biomedical and healthcare sector •• Profiles of leading global players involved in the development and commercialization of nanofibers as well as nanofiber-based application developers in biomedical and healthcare sector Who should buy this Report •• Nanofiber manufacturers and suppliers •• Nanofiber-based biomedical application developers and product manufacturers •• Nanofiber process equipment manufacturers and suppliers •• Corporate strategists, policy advisors and government agencies •• R&D organizations and universities working in the area of nanofibers •• Consultants and analysts •• Investors and funding agencies 80 Companies Profiled Including •• 3-D Matrix Medical Technology •• Boston Scientific Corporation •• Clearbridge Nanomedics Pte Ltd. •• Covidian plc •• Donaldson Company, Inc. •• DuPont de Nemours and Company •• Early Warning Inc. •• Elmarco s.r.o. •• FibeRio Technology Corporation •• Finetex EnE, Inc •• Fresenius Medical Care AG & Co. KGaA •• Hollingsworth & Vose Company •• Irema-Filter Gmbh •• Japan Vilene Company, Ltd. •• Johns Manville Corporation •• Marine Polymer Technologies, Inc. •• Metpro Technologies LLC •• Mitsubishi Rayon Co., Ltd. •• Nano Technics Co. Ltd. •• Nanofiber Solutions •• Nanosys Inc. •• NANOVAL GmbH & Co. KG •• Neotherix Ltd. •• Nicast Ltd. •• NOLabs AB •• Organogenesis Inc. •• PARDAM s.r.o •• Polyremedy, Inc. •• Pyrograf Products, Inc •• Smith & Nephew plc
  • 3. Table of Contents* Executive Summary 4.2. Global Overview of Patents 1. Overview 4.2.1. Year Wise Trend Analysis of Patenting Activity 1.1. Key Takeaways 1.2. Study Goals and Objectives 1.3. Research Methodology 1.4. Introduction to Nanofibers 1.4.1. Theoretical Background and History 1.4.2. Key Features 4.2.2. Geographic and Priority Country Wise Distribution 4.2.3. Top Assignees and Research Focus Areas 4.2.4. Technology Focus 4.2.5. Corporate Patents Landscape 4.2.6. Key Patents 1.4.3. Applications 1.4.4. Industry and Market Overview 2. Scientific and Technological Aspects 5. Market Overview 5.1. Global Nanofibers Market for Biomedical Applications 2.1. Materials Used for Nanofiber Fabrication 5.1.1. Demand and Supply 2.2. Techniques for Nanofiber Fabrication 5.1.2. Market by Materials Type 2.3. Processing of Nanofibers 2.4. Properties and Characterization of Nanofibers 2.5. Technological Issues and Critical Challenges 3. Biomedical and Healthcare Applications 3.1. Tissue Engineering 3.2. Wound Dressing /Healing 3.3. Drug Delivery Systems 3.4. Biosensors 3.5. Medical Devices/Implants 3.6. Medical Filtration Media 3.7. Cosmetics/ Personal Care 3.8. Nanofiber-based Commercial Products 4. Literature and Patent Analysis 4.1. Global Overview of Literature 4.1.1. Year Wise Publication Trends 4.1.2. Geographic Distribution 4.1.3. Publication Trend by Institutes & Organizations 4.1.4. Contribution of Funding Agencies 5.2. Global Market by Biomedical Applications 5.3. Global Nanofiber-enabled Biomedical Market: Trends & Forecasts 5.3.1. Trends and Forecast 5.3.2. Trends and Forecast by Biomedical Applications 5.4. Market Metrics 5.4.1. Porter’s Five Forces Analysis 5.4.2. Key drivers 5.4.3. Challenges 5.4.4. Opportunities 6. Competitive Landscape 6.1. New Product Developments 6.2. Agreements/Partnerships 6.3. Mergers and Acquisitions 7. Technologies Available for Licensing 8. Safety, Health and Environmental Aspects 9. Regulations 10. Company Profiles 4.1.5. The Top 10 Highly Cited Research Publications 4.1.6. Technical Analysis *A sample of table of contents is given here
  • 4. Executive Summary Nanofibers Markets for Biomedical Applications (in US$ million) 180 Nanofibers are an important and versatile class of 155.2 Five year Forecast 160 Five year Trend one-dimensional nanomaterials that has attracted (2013-2018) (2007-2012) 140 increasing attention in the recent years. Nanofibers 113.3 120 ) especially made of biocompatible or biodegradable 100 .8% 6 82.7 (3 ) 80 materials show great potential in biomedical and GR .5% 60.4 29 CA ( 60 healthcare sector due to their unique combination of GR 44.1 CA 40 32.4 properties and intrinsic functionalities. High surface 17.8 24 20 6.6 8.2 10.4 13.4 area and porosity associated with nanofibers that 0 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 enhance adhesion of cells as well as various proteins Year and drug molecules are the key attributes, which Five-year trends (2007-12) and forecasts (2013-18) of make them superior to their micro and macro nanofiber-enabled biomedical markets counterparts composed of same materials. This techno-commercial report discusses various applications of nanofibers in biomedical and healthcare sector and provide them as advanced and potential solutions to the current challenges facing in this rapidly expanding field. Industrial developments in manufacturing technology by employing various proprietary processes based on electrospinning, solution & melt spinning and melt-blowing methods have provided the much-needed momentum for realizing the commercial potential of nanofibers. Major class of nanofibers used in various biomedical and healthcare applications are prepared from various natural and synthetic polymers as well as from their composites with inorganic materials. Ceramic/ inorganic nanofibers and carbon nanofibers are also increasingly being used. Important biomedical applications of nanofibers include filtration, medical textiles, wound healing, tissue engineering & regeneration, biosensors and drug delivery. This report analyses the nanofiber-enabled global biomedical market size in terms of material types, biomedical applications and geographical regions. The report also discusses the key drivers, challenges and opportunities for nanofibers in biomedical industry. Nanofiber industry is a global enterprise serving niche market applications. The global demand of nanofibers in biomedical industry reached 30 metric tons per annum in 2012. The global nanofiber-enabled biomedical market was valued at US$ 24 million in 2012 and is further expected to grow at a Compound Annual Growth Rate (CAGR) of 36.8% during 2013-2018 to reach US$ 155.2 million by 2018. North America tops the list with a share of 50% in global nanofiber-enabled biomedical markets, followed by Europe (37%), Asia-Pacific (12%) and RoW (1%). Polymer nanofibers constitute the largest share of total nanofibers market in terms of materials. The largest market share of nanofibers for biomedical applications is accounted for by filtration followed by medical textiles, wound healing, tissue engineering etc. In the next five years, the consumption is expected to post a considerable growth due to their unique combination of desirable properties, high compatibility with nonwovens and ready availability of biodegradable nanofibers over the conventional fibers. The US is the world leader in research and development in this area followed by Asian countries like China and South Korea. Global nanofiber industry landscape is dotted with numerous start-up companies as well as large corporations. Most of the nanofiber manufacturers are large corporations and some of them have captive uses for their production. Majority of the application developers are however small start-up companies, which either are spin-offs from universities or armed with technologies licensed from universities. This market is still in very nascent stage and therefore ample opportunities exist for the entry of new players across the globe. How to Order? Please make your payment by cheque/DD in favour of “ARCI-Nanotech Insights” payable at Hyderabad or ECS/TRGS or Cridit/Debit cards. Cost (print + soft copy): ` 60,000*, Only soft copy: ` 50,000*, *Add bank charges of ` 90/- for outstation cheques within India Send your order to: H. Purushotham, Scientist-G & Head Centre for Knowledge Management of Nanoscience & Technology (CKMNT) (A Project of ARCI, Department of Science & Technology, Govt. of India) 12-5-32/8, Vijayapuri Colony, Tarnaka, Secunderabad-500 017, India, Telephone: +91 40 2700 7032, +91 40 2700 0251, Telefax: +91 40 2700 7031, E-mail: info@ckmnt.com, Website: www.ckmnt.com