5. Nasya
Easiest employed procedure
OPD Panchakarma
Direct entry to cranial vault
Even unconscious patient can be
managed
Most popular procedure
42. Sushruta , Sharangdhara,
Chakradatta???
6 Bindu each nostril x 1/2/3 times
= 12/24/36 Bindu
8 Bindu each nostril x 1/2/ 3 times
= 16/32/ 48 Bindu
10 Bindu each nostril x 1/2/3 times
= 20/40/60 Bindu
43. Routine BINDU Vs Classical BINDU
0.05ml 0.5ml
10 TIMES MORE
ONE SITTING OF NASYA
10x 1 Instillation = 10 times more
10x 2 Instillation = 20 times more
10x 3 Instillation = 30 times more
57. Contra indications (sneha nasya)
Ajeerna
After food
After drinking water
After bath
Durdina
Nava pratishyaya
During snehapana or anuvasana
63. Procedure
Sneha & sweda – uttamanga
Application of warm oil on palms & soles
Application of warm medicine (pranadi /
pichu)
Mardhana of pada etc
Further sweda
2 or 3 times nasya
Dhumapana / Kabala
Diet & regimen
69. Pratimarsha nasya
Snehangulim dadyat
Dwi bindukah
Eeshath uchhringhitham dravyam
yavath vakthra prapadyate
As a Routine – 15 kala
Ubhayaarthakrith
70. Pratimarsha nasya
No age bar
No contra indication (even in akalavarsha)
No restrictions
No complications
Preferred as routine
Dushthapeenasa / Madyapeetha / Moordhni
krimi / Abalasrothra / Uthklishta dosha /
Klishta dosha
93. Bioavailability
How much of the administered
medication actually ends up in the
blood stream.
Examples:
IV medications are 100% bioavailable.
Most oral medications are about 5%-10%
bioavailable due to destruction in the gut
and liver.
Nasal medications discussed in this lecture
range in the 55% to 100% bioavailability
range - approaching IV delivery systems.
94. First pass metabolism
Molecules absorbed through the gut,
including all oral medications enter the
“portal circulation” and are transported to
the liver.
Liver enzymes then break down most of
these drug molecules and only a small
fraction enter the bodies circulation as
active drug.
Nasally delivered medications avoid the gut
so do not suffer first pass metabolism.
95. Nose brain pathway
The olfactory mucosa (smelling area
in nose) is in direct contact with the
brain and CSF.
Medications absorbed across the
olfactory mucosa directly enter the
brain.
This area is termed the nose brain
pathway and offers a rapid, direct
route for drug delivery to the brain.
96. Lipophilicity
“Lipid Loving.”
Cellular membranes are composed on
layers of lipid material.
Drugs that are lipophilic are easily and
rapidly absorbed across the mucous
membranes.
97. Intranasal Medication -
Absrption
Drugs absorbed via the nasal mucosa:
Are absorbed via the rich vascular plexus of
the nose and directly enter the circulation.
Can be absorbed directly through the
olfactory mucosa into the CSF - giving rapid
brain levels of the drug.
98. Intranasal Medication
Administration: Advantages
Compared to oral medications,
intranasal medication delivery results
in:
Faster delivery to the blood stream
Higher blood levels
No destruction by stomach acid and intestinal
enzymes
No destruction by hepatic first pass
metabolism