A presentation On Rifampicin

2. SUBMITED BY:
MD. AMAN ULLAH
D.V.M 19th Batch
ROLL NO.: 14/01
REG. NO. : 01148
Email: aman.u.ove007@gmail.com
SUBMITED TO:-
DR. ASHIF IMTIAZ SHAWON
Lecturer,
Department of Physiology, Bio-chemistry &
Pharmacology.
an assignment on rifampicin

3. Rifampicin is a broad spectrum, bacteriostatic, 1st line anti-
tuberculosis drug, which was discovered in 1957A.D by Piero
Sensi (Italian scientist), Maria Teresa Timbal(Italian scientist)
and Pinhas Margalith (Israeli scientist) at Laboratory of
Gruppo Lepertit SpA in Milano, Italy. It is also known as
Rifampin, Rifaldazine and Rifamycin.
It is a highly lipid soluble drug can cross Blood Brain barrier
(BBB) and Placental barrier. It’s the advantage of Rifampicin
all other drugs.
Source
Rifampicin is a semi-synthetic derivatives of Rifamycin
antibiotics, which are produced by the fermentation of a
strain of Streptomyces mediterranei (a soil bacteria).

4. PHARMACOKINATICS
ROUTE OF ADMINSTRATION:
ORALLY,
INTRAVENOUS(I/V),
EYE DROP.
ABSORPTION:
WELL ABSORBED IN GASTRO-INTESTINAL TRUCT, should
be taken at least 1 hour before or 2 hour after food
consumption, as absorption is reduced by food.
DISRTIBUTION:
WIDELY IN THE BODY, PENETRATES CAVITYS, CASEOUS
MASSES, PLACENTA AND MENINGES.
METABOLISM: IN LIVER.
EXCIRITION: MAINLY IN BILE, SOME IN
URINE(30%).
Plasma half life (T1/2): 6-8 hours(Horses), 8 hours
(Dog) 3-5 hours(Sheep).

5. BIOAVAIABLITY
PHARMACODYNAMICS
PHYSICAL EFFECT:
RIFAMPICIN IS WELL ABSORBED IN
GASTROINTESTINAL TRUCT WHEN TAKEN
ORALLY AND IS DISTRIBUTED WIDELY IN THE
BODY TISSUE AND FLUID INCLUDING CSF. IT
IS ELIMINATED FROM THE BODY BY BILE
AND, TO A MUCH LESSER EXTENT, IN URINE.
BIOCHEMICAL EFFECT:
RIFAMPICIN IS METABOLIZED IN LIVER.
RIFAMPICIN DOES NOT INHIBIT DNA
DEPENDENT RNA SYNTHESIS IN
ROUTE Bioavailability
Oral 90-93%
Intravenous(I/V) 98.5-100%

6. RIFAMPICIN BINDS TO THE BACTERIAL DNA
DEPENDENT RNA POLYMERASE ENZYME.
INHIBIT RNA SYNTHESIS (m-RNA, r-RNA, t-RNA).
NO PROTEIN SYNTHESIS.
NO GROWTH AND MULTIPLICATION OF BACTERIA.
RIFAMPICIN IS BACTERIOSTATIC.
N.B.: Animal also have DNA dependent RNA
polymerase enzyme but Rifampicin does not
bind with that.

7. PULMONARY TUBERCULOSIS.
LEPROSY (HENSEN’S DISEASE) .
SERIOUS STREPTOCOCCAL INFECTIONS, SUCH
AS OSTEOMYELITIS, PROSTHETIC VALVE
ENDOCARDITIS.
TO EXAMINE THE MENINGOCOCCAL CARRIAGE
& STAPHYLOCOCCAL CARRIAGE.
AS PROPHYLAXIS IN CONTACTS OF CHILDREN
WITH HAEMOPHILUS.
IT WORKS AGAINST Mycobactrium kansasii.
IT IS USEFUL AGAINST VERITY OF SERIOUS
INFECTIONS.
IT HAS BACTERICIDAL ACTION AGAINST GRAM’S
POSITIVE BACTERIAL PATHOGENS.
IT IS EFFECTIVE AGAINST INTRACELLULAR
INFECTIONS.
RIFAMPICIN COMBINED WITH ERYTHROMYCIN IN
THE TREATMENT OF Rhodococcus equi.

8. RIFAMPICIN IS CONTRAINDICATED IN PATIENTS WHO
ARE ALSO RECEIVING ATAZANAVIR, DURAVIR,
FOSAMPRENAVIR, SQUINAVIR, OR TIPRANAVIR DUE TO
THE POTENCIAL OF RIFAMPICIN TO SUBSTANTIALLY
DECREASE PLASMA CONCENTRATION OF THOSE
ANTIVIRAL DRUGS, WHICH MAY RESULT IN LOSS OF
ANTI-VIRAL EFFICACY AND/OR DEVELOPMENT OF
VIRAL RESISTANCE.
SIDE EFFECT
RIFAMPICIN MAY CAUSE-
 UPSET STOMACH,
 HEAT BURN,
 NAUSEA,
 MENSTRUAL CHANGES,
 HEADACHE,
 DROWSINESS,
 DIZZINESS,
 ANEMIA,
 RED/ORANGE URINE &
 LOSS OF APPETITE.

9. RIFAMPICIN HAS ADVERSE EFFECT LIKE THIS-
 HARMLESS ORANGE/RED COLORATION OF
BODY FLUID, SUCH AS SALIVA, TEAR, URINE,
SWEAT ETC.
 DAMAGE OF LIVER- CHOLESTATIC
JAUNDICE, HEPATITIS.
 HEMOLYTIC ANEMIA,
 RUSH,
 THROMBOCYTOPENIA,
 NEPHROTOXICITY,
 INDUCE HEPATIC MICROSOMAL ENZYME SO
CHANCE OF ANTI-COAGULANT, ANTI-
CONVULCENT AND CONTRACEPTIVE
FALEURE &
 ANECDOTAL CLINICAL REPORTS INDICATE

10. 3(THREE) WEEKS AFETER LAST DOSE.
GENERIC DOSE
10 mg/Kg BODY WEIHT ORALLY.
DOSE
Animal Dose Route Repeat
Cattle 5mg/kg body weight Oral Twice daily.
Goat 0.3-0.5mg/kg body
weight
I/V, I/M, S/C Once daily.
Sheep 20mg/kg body weight oral Once daily.
Chicken 10mg/kg body weight I/V Only Once.
Dog 10mg/kg body weight Oral Thrice daily.
Cat 10-15mg/kg body
weight
Oral Thrice daily.
Horse 10 mg/kg body
weight
I/V, I/M Once daily.
25mg/kg body weight Oral Once daily.
Pig 5.3-7.9mg/kg body
weight
Oral Once daily

11. Drugs Result Effect
Rifampicin+Oral
Contraceptives(OCP)
Contraceptive
failure.
Antagonism
Rifampicin+Oral anti-
coagulents
Coagulation. Antagonism
Rifampicin+anti-convulsant Convulsion. Antagonism
Rifampicin+ Oral hypoglycemic
drug
Hyperglycemia. Synergism
Rifampicin + Isoniazide Synergism
TRADE NAME
SL.
No.
Name Form Manufacturing Company
1 Myconil 150 Rifampicin 150mg
capsule
BEXIMCO Pharmaceuticals
Ltd.
2 Ifacin 150 Rifampicin 150mg
capsule
Square Pharmaceuticals Ltd.
3 A Rifam 450 Rifampicin 450mg
capsule
ACME Laboratories Ltd.
4 Rifanol 450 Rifampicin 450mg
capsule
Eskayef Bangladesh Ltd.
5 Rifampicin 150 Rifampicin 150mg tablet Popular Pharmaciticals Ltd.

12. THANKS TO ALL…