1) Definition of PUD
2) Pathogenesis of PUD
3) Risk Factors for PUD
4) Morphology of PUD
5) Clinical features
6) Complications
7) Summary
This presentation was presented in MULTI SYSTEM SEMINAR by a 2nd year MBBS-2015 student of BPKIHS, Dharan, NEPAL.
3. DEFINITION
Ulcer is defined as disruption of the mucosal integrity of
stomach and/or duodenum leading to a local defect or
excavation due to active inflammation.
Erosion differs from an ulcer in being partial thickness
mucosal defect.
Peptic ulcers are chronic most often solitary lesions that
occur in any portion of GIT exposed to the aggressive action
of acid-peptic juices.
8. RISK FACTORS FOR PUD
•H. Pylori infection
•NSAIDs
•Cigarette use
•COPD
•Ilicit drugs like cocaine
•Alcoholic cirrhosis
•Psychological stress
•Endocrine cell hyperplasia
•ZE syndrome
•Viral infection (CMV, HSV)
9. Organism attached to mucus-secreting cells of
gastric mucosa by adhesins like BabA and SabA
H. Pylori transmitted by fecal-oral/ oral-oral route
In the stomach it swims in viscous mucus due to flagella
Ammonia neutralizes HCl in stomach
Production of large amount of ammonia from urea
by bacterial urease
Organism survival
Inflammatory response
Damage to mucus
Gastritis and peptic ulcers
13. SITES OF PEPTIC ULCERS
Duodenum: 1st portion, Anterior wall
Stomach: usually antrum, lesser curvature
(common), anterior and posterior wall, greater
curvature (less common)
In the margins of a gastroenterostomy
(stomal ulcer)
In the duodenum, stomach or jejunum of
patients with Zollinger-Ellison syndrome
With or adjacent to a Meckel’s diverticulum.
14. MORPHOLOGY
GROSS
•Round to oval, sharply punched-out defect
•Mucosal margin usually level with the
surrounding mucosa or only slightly elevated
•Radiating mucosal folds
•Base is smooth and clear, owing to the peptic
digestion of exudates
15.
16. MORPHOLOGY
MICROSCOPY
Four zones are seen
•Layer of necrotic fibrinoid debris
•Zone of acute inflammatory infiltrate
(neutrophils)
•Active granulation tissue with
mononuclear leukocytes
•Fibrous scarring
17. CLINICAL FEATURES
•Epigastric pain
•Dyspepsia, including belching, bloating, distention,
and fatty food intolerance
•Heartburn
•Chest discomfort
•Hematemesis or melena resulting from
gastrointestinal bleeding
18. COMPLICATIONS
• Hemorrhage
Blood vessels damaged as ulcer erodes into the muscles GIT
Coffee ground vomitus or occult blood in tarry stools
• Perforation
An ulcer can erode through the entire wall
Bacteria and partially digested food spill into peritoneum
:Peritonitis
• Narrowing and obstruction (pyloric)
Swelling and scarring can cause obstruction of food leaving
stomach : Repeated vomiting