Lecture presented at 26th.jan 2021 About drugs administration during conventional dialysis sessions

1. Drugs used during
conventional renal dialysis
sessions
Depend on Dialysis of Drugs, 2013
(George R. Bailie & Nancy A. Mason, USA)
Alaa Fadhel Hassan (MSc. Pharmacology)
Drug information centre
Al-Mahmoudiya General Hospital

2. Entrance
 Patient of renal dialysis need special care.
 Drugs used for renal dialysis pt. may affect renal function
(contraindication, caution or dosage adjustment) or may be
affected by dialysis process itself.
 Conventional hemodialysis is defined as the use of a dialysis
membrane whose in vitro coefficient of ultrafiltration (KUf) ≤8
mL/hour/mm Hg. (Data are placed in the conventional column
if the literature does not specify the type of dialysis membrane
employed).

3. Drugs which dialysis enhances plasma clearance by 30%
or more. Supplemental dosing may be required or dosing
after dialysis should be considered (Yes).
Acetamionphen
(paracetamol)
(NS)
Aminocaproic
acid (NS)
Aspirin (NS) Ceftazidime
(NS)
Clavulanic acid
(NS)
Acetylcysteine
(7.5)
Aminophylline
(NS)
Atenolol (NS) Cefuroxime (NS) Cotrimoxazole
(NS)
Acyclovir (NS) Amoxicillin (NS) Calcium
carbonate
Cephalexin
(Keflex) (NS)
Enalapril (NS)
Allopurinol (NS) Ampicillin (NS) Captopril (NS) Chloram-
phenicol (NS)
Fluconazole
(NS)
Amikacin (NS) Ascorbic acid
(Vitamin C) (5.5)
Cefpodoxime
(NS)
Chlorphenir-
amine
(Histadine) (NS)
Folic acid (NS)

4. yes
Gabapentin
(NS)
Levocarnitine
(NS)
Meropenem
(NS)
Octreotide (NS) Streptomycin
(NS)
Gentamicin
(NS)
Linzolid (NS) Metformin (NS) Oseltamivir
(Tamiflu) (2.8-4)
Tazobactam
(NS)
Imipenem (NS) Lisinopril (NS) Methyldopa
(NS)
Penicillin (NS) Theophylline
(NS)
Isosorbide
mononitrtae
(NS)
Mannitol (NS) Methyl-
prednisolone
(NS)
Piperacillin (NS) Trimethoprim
(NS)
Levetiracetam
(NS)
Melatonin (NS) Minoxidil (NS) Pregabalin (NS)

5. Drugs which dialysis does not have a clinically important
effect on plasma clearance. Supplemental dosing is
usually not required (No)
Albuterol
(Salbutamol)
(NS)
Cimetidine
(Tagamet) (NS)
Chloroquine
(NS)
Desloratadine
(NS)
Dopamine (NS)
Alprazolam Candesartan
(NS)
Ciprofloxacin
(Ciprodar) (NS)
Dexamethasone
(Decadron) (NS)
Doxycycline
(Doxidar) (NS)
Amiodaron (NS) Carbamazepine
(NS) (5.5)
Clindamycin
(NS)
Diazepam
(Valium) (NS)
Enoxaparin (NS)
Amlodipine (NS) Carbimazole Colchicine (NS) Digoxin (NS) Epoetin alfa
(NS)
Atorvaststin
(NS)
Carvedilol (NS) Cortisone (NS) Diltiazem (NS) Erythromycin
(NS)
Bisoprolol (NS) Ceftriaxone (NS) Cyanocobal-
amine (Vitamin
B12) (NS)
Dobutamine
(NS)
Estradiol (NS)

6. NO
Estrone (NS) Furosemide
(Lasix) (NS)
Hydrochoro-
thiazide (NS)
Isosorbide
dinitrate (Isordil)
(NS)
Mefenamic acid
(NS)
Famotidine (NS) Fusidic acid (NS) Hydroxy-
carbamide
(hydroxyurea)
(NS)
Labetalol (NS) Meloxicam (NS)
Fenofibrate (NS) Glibenclamide
(Glyburide) (NS)
Ibuprofen (NS) Levocetirizine
(NS)
Meperidine (NS)
/(pethidine) ND
(8)
Ferric gluconate
(NS)
Glyceryl
trinitrate
(Angised) (NS)
Indomethacin
(NS)
Lidocaine/
Lignocaine (NS)
Methadone (NS)
Fexofenadine
(NS)
Heparin (NS) Insulin (NS) Lincomycin (NS) Metoclopramide
(NS)
Flucloxacillin
(NS)
Hydralazine (NS) Isoniazid (NS) Mebendazole
(NS)
Naltrexone (NS)

7. NO
Naproxen (NS) Pioglitazone
(NS)
Ranitidine
(Zantac) (NS)
Silver
sulfadiazine
(NS)
Tramadol (NS)
Oxacillin (NS) Prednisone (NS) Ribavirin (NS) Sitagliptin (NS) Valsartan (NS)
Pantoprazole
(5.1)
Propranolol (NS) Rifampin
(Rifampicin)
(NS)
Terazosin (NS) Vancomycin
(NS)
Pentobarbital
(NS)
Propylthiouracil
(NS)
Rosiglitazone
(NS)
Tetracycline (NS) Verapamil (NS)
Phenytoin (NS) Pseudoeph-
edrine (NS)
Rosuvastatin
(NS)
Thiamine
(Vitamin B1)
(NS)
Warfarin (NS)

8. Drugs which no published data exist but physicochemical
characteristics of the drug suggest that significant drug
removal is unlikely during dialysis (U)
Adenosine Clotrimazole Ethinyl estradiol Human growth
hormon
Iron sucrose
(Venofer)
Albumin Dextran Ferrous salt Hydroxocobala
min
Lactulose
Celecoxib Diclofenac
(Voltarin)
Gliclazide Insulin aspart Levodopa
Cholecalciferol
(Vitamin D3)
Diphen-
hydramine
(Allermine)
Glimepiride Iron dextran
(Imferon)
Levofloxacin
Clopidogrel
(Plavix)
Esomeprazole Glucagon Iron
polymaltose
complex
Levonorgestrel

9. U
Levothyroxine Nystatin Piroxicam Sevelamer Streptokinase
Levodopa Omeprazole Prednisolone Sildenafil
(Viagra)
Tamsulosin
(Fosamex)
Mifepristone Ondasteron
(Zofran)
Progesterone Simethicone Thyroxine
Misoprostol
(Cytotec)
Orlistat Rabeprazole Simvastatin Vecuronium
Montelukast
(Monax)
Pentoxifylline Rho (D) Ig Spironolactone
(Aldactone)
Zafirlukast

10. Drug which no data exist on their dialyzability with
this type of dialysis (ND).
Adrenaline
(Epinephrine)
Ephedrine Leucovorin Norethistrone Spiramycin
1-α Alfacalcidol
(1-alfa)
Ergometrine
(Oxytocin)
Mebeverine
(Duspatalin)
Norgestrel Sumatriptan
Ammonium
chloride
Estrogens,
conjugated
Moerphine Ostriol Tamoxifen
Betamethasone
(Betacort)
Factor VIII
(antihemophilic
factor)
Naloxone Omega 3 acid
ethyl esters
Phytonadione
(Vitamin K)
Carbidopa/
levodopa (ND/U)
Fibrinogen Niacin
(Vitamin B3)
Orphinadrine Zinc
Clarithromycin Hydroxy-
chloroquine
Norepinephrine Tranexamic acid Tocopherol
(Vitamin E)
Cyproheptadine
(
Ketotifen Norethindrone Pyridoxine
(Vitamin B6)

11. Drugs which no published data exist but
physicochemical characteristics of the drug
suggest that significant drug removal is likely
during dialysis (L).
Drugs which data of the type of membrane was
not specified (NS).

12. Thank You