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Human Biology 2




Dr. Ahmed Osman
Lymphatic system


•Definition
•Function of lymph (nodes)
•Dynamics of circulation
•Role in dental practice
•Clinical applications
(Regional lymph
nodes).
Lymphatic system

   As blood flows through the
    capillaries of the body, two
    opposing forces are exerted.
   Blood pressure tends to force fluid
    through the walls of the capillaries
    into the tissue spaces, whereas the
    osmotic pressure of the blood
    tends to draw fluid into the vessels.
Lymphatic system

•   Fluid tends to pass out of vessels on the arterial side.
•   About 90% of this fluid returns to the blood vessels, the
    remaining 10% entering lymph vessels that eventually carry
    this lymph back to the venous circulation after passing
    through the lymph nodes.
 The lymphatic system is the part of the
  immune system comprising a network of
  conduits called lymphatic vessels that carry a
  clear fluid called lymph (from Latin lympha
  "water") in a unidirectional pathway.
 The widely and extensively dispersed vessel
  system collects tissue fluids from all regions
  of the body to eventually convey them
  towards the heart.
• It is responsible for the removal of interstitial fluid from tissues i.e. act as "drains" to collect
the excess fluid and return it to the venous blood just before it reaches the heart preventing
massive edema (which can cause tissue destruction: “pressure necrosis”).
•Returns back to circulation, the protiens that may have escaped into interstitial spaces.

   Lymphatic tissue is a specilized connective tissue - reticular
    connective, that contains large quantities of lymphocytes(filter
    fluids prior to adding it to circulation).
   It transports immune cells to and from the lymph nodes in to the
    bones
   The lymph transports antigen-presenting cells (APCs), such as
    dendritic cells, to the lymph nodes where an immune response is
    stimulated.
   works with the circulatory system to deliver nutrients, oxygen, and
    hormones from the blood to the cells that make up the tissues of
    the body.
   It absorbs and transports fatty acids and fats as chyle to the
    circulatory system
Circulation at the rate of 125 mL/hour.




The “pump” is: breathing & muscle contractions
A sound knowledge of the regional lymph nodes of
  the head and neck is very important for dentists
  because it is a reliable guide towards the origin
  of problem, and because of the possible
  involvement of
the lymphatic system in the
spread of infection or the spread
of malignant tumour cells
(metastasis).

Role in headache?
Clinical significance:
2. Diagnostic value
3. Aid in prediction of treatment outcome
   (modification of treatment plan/course)
4. Prediction of disease history and therefore
   prognosis.
5. Lymph vessels can also transmit other
   substances such as injected material or
   neoplastic cells.
Classification of nodes
     in head and neck region
Classification of nodes
               in head and neck region




The lymph nodes in the head and neck region
           can be grouped into:
           •     Superficial nodes
                 •   Deep nodes.
   The superficial cervical lymph nodes lie
    above the investing layer of the deep fascia.
                                          fascia

   They consist of a few small nodes that lie
    superficial to the external jugular and
    anterior jugular veins.
1.   Submental
2.   Submandibular
3.   Buccal
4.   Parotid (pre-auricular)
5.   Mastoid (retro auricular/ post-auricular)
6.   Occipital
7.   Superficial cervical
8.   Anterior cervical.
Superficial
cervical nodes
Upper deep cervical

c       Lower deep cervical

        c     Waldyer’s ring

    c        Nodes of midline
Deep cervical nodes

   The upper deep cervical (Jugulo-digastric
    group: lie along the upper part of internal
    jugular vein deep to the sternomastoid.

   The lower deep cervical (jugulo-omohyoid
    gp): arranged along the lower part of IJV also
    deep to the SMm.
Deep cervical nodes
   The waldyer’s ring is formed by: lingual, palatine,
    tubal, and pharyngeal tonsils.
   Midline nodes are termed in correspondence to the
    anatomical area where they exist:
w   Infrahyoid
d   Prelaryngeal
d   Pretracheal
d   Paratracheal
 Efferents of lower deep cervicals then collect
  into larger lymph vessel called the “jugular
  lymph trunk”.
 This trunk joins another two lymph trunks
  lymph (subclavian and brachiocephalic trunks)
  to form the so called the “lymph ducts” (right or
  left).
 This “duct” finally opens into the angle between
  internal jugular and subclavian veins to drain its
  contents back to venous circulation.
Thoracic duct


The right and left lymph ducts are NOT of equal size.
The left lymph duct (also called the “Thoracic duct” )
which is considered the largest lymphatic vessel in
 the body.
 It collects most of the lymph in the body (except
   that from the right arm and the right side of the
    chest, neck and head, which is collected by the
                right lymphatic duct).
Thoracic duct



•   It begins down as low as level of L2
    (at the cisterna chyli) and extends upward to
     drain into the region near the junction of the
     left subclavian and internal jugular veins, with
     tributaries from the cervical, subclavian and
     mediastinal trunks.
Lymphatic drainage
600-700
lymph nodes
present in
the average
human body
Clinical applications

   The first sign of a malignancy (especially an
    intra-abdominal one) may be an enlargement
    of the lymph node that lies in the left
    supraclavicular area, in the vicinity where the
    thoracic duct empties into the left subclavian
    vein (Virchow’s node).
   When the thoracic duct is blocked or
    damaged a large amount of lymph can
    quickly accumulate in the pleural cavity,
    (Chylothorax).
•   The scalp drains into the occipital, mastoid and
    parotid nodes.
•   Lower eye lid and anterior cheek drains into buccal
    LNs.
•   The cheeks drain into the parotid, buccal and
    submandibular nodes.
•   The upper lips and sides of the lower lips drain into
    the submandibular nodes.
    While the middle third of the lower lip drains into
    the submental nodes
•   The skin of the neck drains into the cervical nodes.
• The gingivae drain into the submandibular,
  submental and upper deep cervical lymph
  nodes.
• The palate drains via lymph vessels that pass
  through the pharyngeal wall to the upper deep
  cervical nodes.
• Teeth drain into the submandibular and deep
  cervical lymph nodes.
• Anterior part of mouth floor drain into
  submental and upper deep cervical while
  posterior part into submandibular and upper
  deep cervical.
Drainage of oral structures
Drainage of oral structures
Lymphatic drainage of tongue
•   In relation to the lymph drainage of the tongue, the farther
    backward the origin of the vessel, the lower down is the
    lymph node in which it ends.
•   Lymph vessels in the floor of the mouth pierce the
    mylohyoid muscle and travel to the submental and
    submandibular lymph nodes.
•   Some medially located lymphatics in the tongue also cross
    the midline.
Lymphatic drainage of tongue




                 What is radical neck dissection?& why?
Lymphatics of the head & neck

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Lymphatics of the head & neck

  • 1. Human Biology 2 Dr. Ahmed Osman
  • 2. Lymphatic system •Definition •Function of lymph (nodes) •Dynamics of circulation •Role in dental practice •Clinical applications (Regional lymph nodes).
  • 3. Lymphatic system  As blood flows through the capillaries of the body, two opposing forces are exerted.  Blood pressure tends to force fluid through the walls of the capillaries into the tissue spaces, whereas the osmotic pressure of the blood tends to draw fluid into the vessels.
  • 4. Lymphatic system • Fluid tends to pass out of vessels on the arterial side. • About 90% of this fluid returns to the blood vessels, the remaining 10% entering lymph vessels that eventually carry this lymph back to the venous circulation after passing through the lymph nodes.
  • 5.  The lymphatic system is the part of the immune system comprising a network of conduits called lymphatic vessels that carry a clear fluid called lymph (from Latin lympha "water") in a unidirectional pathway.  The widely and extensively dispersed vessel system collects tissue fluids from all regions of the body to eventually convey them towards the heart.
  • 6. • It is responsible for the removal of interstitial fluid from tissues i.e. act as "drains" to collect the excess fluid and return it to the venous blood just before it reaches the heart preventing massive edema (which can cause tissue destruction: “pressure necrosis”). •Returns back to circulation, the protiens that may have escaped into interstitial spaces.  Lymphatic tissue is a specilized connective tissue - reticular connective, that contains large quantities of lymphocytes(filter fluids prior to adding it to circulation).  It transports immune cells to and from the lymph nodes in to the bones  The lymph transports antigen-presenting cells (APCs), such as dendritic cells, to the lymph nodes where an immune response is stimulated.  works with the circulatory system to deliver nutrients, oxygen, and hormones from the blood to the cells that make up the tissues of the body.  It absorbs and transports fatty acids and fats as chyle to the circulatory system
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  • 9. Circulation at the rate of 125 mL/hour. The “pump” is: breathing & muscle contractions
  • 10. A sound knowledge of the regional lymph nodes of the head and neck is very important for dentists because it is a reliable guide towards the origin of problem, and because of the possible involvement of the lymphatic system in the spread of infection or the spread of malignant tumour cells (metastasis). Role in headache?
  • 11. Clinical significance: 2. Diagnostic value 3. Aid in prediction of treatment outcome (modification of treatment plan/course) 4. Prediction of disease history and therefore prognosis. 5. Lymph vessels can also transmit other substances such as injected material or neoplastic cells.
  • 12. Classification of nodes in head and neck region
  • 13. Classification of nodes in head and neck region The lymph nodes in the head and neck region can be grouped into: • Superficial nodes • Deep nodes.
  • 14. The superficial cervical lymph nodes lie above the investing layer of the deep fascia. fascia  They consist of a few small nodes that lie superficial to the external jugular and anterior jugular veins.
  • 15. 1. Submental 2. Submandibular 3. Buccal 4. Parotid (pre-auricular) 5. Mastoid (retro auricular/ post-auricular) 6. Occipital 7. Superficial cervical 8. Anterior cervical.
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  • 18. Upper deep cervical c Lower deep cervical c Waldyer’s ring c Nodes of midline
  • 19. Deep cervical nodes  The upper deep cervical (Jugulo-digastric group: lie along the upper part of internal jugular vein deep to the sternomastoid.  The lower deep cervical (jugulo-omohyoid gp): arranged along the lower part of IJV also deep to the SMm.
  • 21. The waldyer’s ring is formed by: lingual, palatine, tubal, and pharyngeal tonsils.  Midline nodes are termed in correspondence to the anatomical area where they exist: w Infrahyoid d Prelaryngeal d Pretracheal d Paratracheal
  • 22.  Efferents of lower deep cervicals then collect into larger lymph vessel called the “jugular lymph trunk”.  This trunk joins another two lymph trunks lymph (subclavian and brachiocephalic trunks) to form the so called the “lymph ducts” (right or left).  This “duct” finally opens into the angle between internal jugular and subclavian veins to drain its contents back to venous circulation.
  • 23. Thoracic duct The right and left lymph ducts are NOT of equal size. The left lymph duct (also called the “Thoracic duct” ) which is considered the largest lymphatic vessel in the body. It collects most of the lymph in the body (except that from the right arm and the right side of the chest, neck and head, which is collected by the right lymphatic duct).
  • 24. Thoracic duct • It begins down as low as level of L2 (at the cisterna chyli) and extends upward to drain into the region near the junction of the left subclavian and internal jugular veins, with tributaries from the cervical, subclavian and mediastinal trunks.
  • 27. Clinical applications  The first sign of a malignancy (especially an intra-abdominal one) may be an enlargement of the lymph node that lies in the left supraclavicular area, in the vicinity where the thoracic duct empties into the left subclavian vein (Virchow’s node).  When the thoracic duct is blocked or damaged a large amount of lymph can quickly accumulate in the pleural cavity, (Chylothorax).
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  • 30. The scalp drains into the occipital, mastoid and parotid nodes. • Lower eye lid and anterior cheek drains into buccal LNs. • The cheeks drain into the parotid, buccal and submandibular nodes. • The upper lips and sides of the lower lips drain into the submandibular nodes. While the middle third of the lower lip drains into the submental nodes • The skin of the neck drains into the cervical nodes.
  • 31. • The gingivae drain into the submandibular, submental and upper deep cervical lymph nodes. • The palate drains via lymph vessels that pass through the pharyngeal wall to the upper deep cervical nodes. • Teeth drain into the submandibular and deep cervical lymph nodes. • Anterior part of mouth floor drain into submental and upper deep cervical while posterior part into submandibular and upper deep cervical.
  • 32. Drainage of oral structures
  • 33. Drainage of oral structures
  • 34. Lymphatic drainage of tongue • In relation to the lymph drainage of the tongue, the farther backward the origin of the vessel, the lower down is the lymph node in which it ends. • Lymph vessels in the floor of the mouth pierce the mylohyoid muscle and travel to the submental and submandibular lymph nodes. • Some medially located lymphatics in the tongue also cross the midline.
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  • 37. Lymphatic drainage of tongue What is radical neck dissection?& why?